Modulation of RAAS receptors and miRNAs in COVID-19: implications for disease severity, immune response, and potential therapeutic targets

Modulation of RAAS receptors and miRNAs in COVID-19: implications for disease severity, immune response, and potential therapeutic targets

Abstract The SARS-CoV-2 spike protein interacts with ACE2, a key receptor within the renin-angiotensin-aldosterone system (RAAS), which plays a critical role in maintaining vascular homeostasis, regulating blood pressure, and modulating inflammation. An observational study analyzed the gene expressi...

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Main Authors: Thais Freitas Barreto Fernandes, Jose Henrique Pilotto, Priscila Alves Cezar, Fernanda Heloise Côrtes, Mariza G. Morgado, Carmem Beatriz W. Giacoia-Gripp, Nathalia Beatriz Ramos De Sá, Andressa Da Silva Cazote, Agatha Freixinho Neves, Marcel De Souza Borges Quintana, Maria Pia Diniz Ribeiro, Sandra Wagner Cardoso, Valdiléa G. Veloso, Beatriz Grinsztejn, Dalziza Victalina De Almeida
Format: Article
Language:English
Published: BMC 2025-03-01
Series:BMC Infectious Diseases
Subjects:
SARS-CoV-2
COVID-19
RAAS
ACE2
miRNA
Online Access:https://doi.org/10.1186/s12879-025-10803-y
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