Rofecoxib-Induced Hepatotoxicity: A Forgotten Complication of the Coxibs
Rofecoxib is a member of the coxib family of nonsteroidal anti-inflammatory drugs that selectively inhibit cyclooxygenase-2. Although the coxibs are generally well-tolerated, rofecoxib was recently withdrawn from the market due to concerns regarding cardiovascular safety. Rare cases of hepatic injur...
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2006/356434 |
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| author | Brian Yan Yvette Leung Stefan J Urbanski Robert P Myers |
| author_facet | Brian Yan Yvette Leung Stefan J Urbanski Robert P Myers |
| author_sort | Brian Yan |
| collection | DOAJ |
| description | Rofecoxib is a member of the coxib family of nonsteroidal anti-inflammatory drugs that selectively inhibit cyclooxygenase-2. Although the coxibs are generally well-tolerated, rofecoxib was recently withdrawn from the market due to concerns regarding cardiovascular safety. Rare cases of hepatic injury attributable to the coxibs have been reported. In the present study, two additional cases of severe hepatotoxicity are described in patients with cholestatic symptoms and abnormal liver biochemistry, shortly following the initiation of rofecoxib for arthritic complaints. In both cases, liver histology was compatible with drug-induced hepatotoxicity, and rapid clinical and biochemical improvements were observed following rofecoxib discontinuation. With new coxibs and expanding indications on the horizon, physicians in all areas of practice must be aware of this disorder and consider it in any patient who develops hepatic dysfunction after taking a coxib. |
| format | Article |
| id | doaj-art-9b5cc3fe6e324d508a5ce8a340292865 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-9b5cc3fe6e324d508a5ce8a3402928652025-02-03T01:25:34ZengWileyCanadian Journal of Gastroenterology0835-79002006-01-0120535135510.1155/2006/356434Rofecoxib-Induced Hepatotoxicity: A Forgotten Complication of the CoxibsBrian Yan0Yvette Leung1Stefan J Urbanski2Robert P Myers3Liver Unit, Division of Gastroenterology, Department of Medicine, University of Calgary, Calgary, Alberta, CanadaLiver Unit, Division of Gastroenterology, Department of Medicine, University of Calgary, Calgary, Alberta, CanadaDepartment of Pathology, University of Calgary, Calgary, Alberta, CanadaLiver Unit, Division of Gastroenterology, Department of Medicine, University of Calgary, Calgary, Alberta, CanadaRofecoxib is a member of the coxib family of nonsteroidal anti-inflammatory drugs that selectively inhibit cyclooxygenase-2. Although the coxibs are generally well-tolerated, rofecoxib was recently withdrawn from the market due to concerns regarding cardiovascular safety. Rare cases of hepatic injury attributable to the coxibs have been reported. In the present study, two additional cases of severe hepatotoxicity are described in patients with cholestatic symptoms and abnormal liver biochemistry, shortly following the initiation of rofecoxib for arthritic complaints. In both cases, liver histology was compatible with drug-induced hepatotoxicity, and rapid clinical and biochemical improvements were observed following rofecoxib discontinuation. With new coxibs and expanding indications on the horizon, physicians in all areas of practice must be aware of this disorder and consider it in any patient who develops hepatic dysfunction after taking a coxib.http://dx.doi.org/10.1155/2006/356434 |
| spellingShingle | Brian Yan Yvette Leung Stefan J Urbanski Robert P Myers Rofecoxib-Induced Hepatotoxicity: A Forgotten Complication of the Coxibs Canadian Journal of Gastroenterology |
| title | Rofecoxib-Induced Hepatotoxicity: A Forgotten Complication of the Coxibs |
| title_full | Rofecoxib-Induced Hepatotoxicity: A Forgotten Complication of the Coxibs |
| title_fullStr | Rofecoxib-Induced Hepatotoxicity: A Forgotten Complication of the Coxibs |
| title_full_unstemmed | Rofecoxib-Induced Hepatotoxicity: A Forgotten Complication of the Coxibs |
| title_short | Rofecoxib-Induced Hepatotoxicity: A Forgotten Complication of the Coxibs |
| title_sort | rofecoxib induced hepatotoxicity a forgotten complication of the coxibs |
| url | http://dx.doi.org/10.1155/2006/356434 |
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