EXPERIENCE OF USING BEDAQUILINE IN THE TREATMENT OF PULMONARY TUBERCULOSIS PATIENTS WITH MULTIPLE ANDEXTENSIVE DRUG RESISTANCE
The article presents the evaluation of safety and efficiency of chemotherapy regimens including the new anti-tuberculosis agent of bedaquiline in 21 pulmonary tuberculosis patients with multiple and extensive drug resistance who were treated in Stavropol Regional Clinical TB Dispensary from 2014 to...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2018-01-01
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| Series: | Туберкулез и болезни лёгких |
| Subjects: | |
| Online Access: | https://www.tibl-journal.com/jour/article/view/1075 |
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| author | N. M. Konovаlovа V. S. Odinets T. I. Vаsilenko T. A. Zаdremаylovа |
| author_facet | N. M. Konovаlovа V. S. Odinets T. I. Vаsilenko T. A. Zаdremаylovа |
| author_sort | N. M. Konovаlovа |
| collection | DOAJ |
| description | The article presents the evaluation of safety and efficiency of chemotherapy regimens including the new anti-tuberculosis agent of bedaquiline in 21 pulmonary tuberculosis patients with multiple and extensive drug resistance who were treated in Stavropol Regional Clinical TB Dispensary from 2014 to 2017. It was found out that regimens with bedaquiline were satisfactory tolerated, and the attempt to identify the agent causing adverse events within a multi-component chemotherapy regimen failed. The majority of adverse events were reversible, but they required temporary cancellation of chemotherapy in 5 patients with the consequent continuation of treatment with this regimen after adverse events were managed. The evaluation of treatment efficiency with 6-month treatment with bedaquiline showed sputum conversion in 94.4% of cases and healing of cavities in 72.2%. |
| format | Article |
| id | doaj-art-9b4ed48dde014cdea99c05ca12d0602f |
| institution | OA Journals |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| publishDate | 2018-01-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj-art-9b4ed48dde014cdea99c05ca12d0602f2025-08-20T02:05:56ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062018-01-019512495310.21292/2075-1230-2017-95-12-49-531075EXPERIENCE OF USING BEDAQUILINE IN THE TREATMENT OF PULMONARY TUBERCULOSIS PATIENTS WITH MULTIPLE ANDEXTENSIVE DRUG RESISTANCEN. M. Konovаlovа0V. S. Odinets1T. I. Vаsilenko2T. A. Zаdremаylovа3Stavropol Regional Clinical TB DispensaryStavropol Regional Clinical TB DispensaryStavropol Regional Clinical TB DispensaryStavropol Regional Clinical TB DispensaryThe article presents the evaluation of safety and efficiency of chemotherapy regimens including the new anti-tuberculosis agent of bedaquiline in 21 pulmonary tuberculosis patients with multiple and extensive drug resistance who were treated in Stavropol Regional Clinical TB Dispensary from 2014 to 2017. It was found out that regimens with bedaquiline were satisfactory tolerated, and the attempt to identify the agent causing adverse events within a multi-component chemotherapy regimen failed. The majority of adverse events were reversible, but they required temporary cancellation of chemotherapy in 5 patients with the consequent continuation of treatment with this regimen after adverse events were managed. The evaluation of treatment efficiency with 6-month treatment with bedaquiline showed sputum conversion in 94.4% of cases and healing of cavities in 72.2%.https://www.tibl-journal.com/jour/article/view/1075tuberculosistreatmentbedaquilinesirturomultiple drug resistanceextensive drug resistance |
| spellingShingle | N. M. Konovаlovа V. S. Odinets T. I. Vаsilenko T. A. Zаdremаylovа EXPERIENCE OF USING BEDAQUILINE IN THE TREATMENT OF PULMONARY TUBERCULOSIS PATIENTS WITH MULTIPLE ANDEXTENSIVE DRUG RESISTANCE Туберкулез и болезни лёгких tuberculosis treatment bedaquiline sirturo multiple drug resistance extensive drug resistance |
| title | EXPERIENCE OF USING BEDAQUILINE IN THE TREATMENT OF PULMONARY TUBERCULOSIS PATIENTS WITH MULTIPLE ANDEXTENSIVE DRUG RESISTANCE |
| title_full | EXPERIENCE OF USING BEDAQUILINE IN THE TREATMENT OF PULMONARY TUBERCULOSIS PATIENTS WITH MULTIPLE ANDEXTENSIVE DRUG RESISTANCE |
| title_fullStr | EXPERIENCE OF USING BEDAQUILINE IN THE TREATMENT OF PULMONARY TUBERCULOSIS PATIENTS WITH MULTIPLE ANDEXTENSIVE DRUG RESISTANCE |
| title_full_unstemmed | EXPERIENCE OF USING BEDAQUILINE IN THE TREATMENT OF PULMONARY TUBERCULOSIS PATIENTS WITH MULTIPLE ANDEXTENSIVE DRUG RESISTANCE |
| title_short | EXPERIENCE OF USING BEDAQUILINE IN THE TREATMENT OF PULMONARY TUBERCULOSIS PATIENTS WITH MULTIPLE ANDEXTENSIVE DRUG RESISTANCE |
| title_sort | experience of using bedaquiline in the treatment of pulmonary tuberculosis patients with multiple andextensive drug resistance |
| topic | tuberculosis treatment bedaquiline sirturo multiple drug resistance extensive drug resistance |
| url | https://www.tibl-journal.com/jour/article/view/1075 |
| work_keys_str_mv | AT nmkonovalova experienceofusingbedaquilineinthetreatmentofpulmonarytuberculosispatientswithmultipleandextensivedrugresistance AT vsodinets experienceofusingbedaquilineinthetreatmentofpulmonarytuberculosispatientswithmultipleandextensivedrugresistance AT tivasilenko experienceofusingbedaquilineinthetreatmentofpulmonarytuberculosispatientswithmultipleandextensivedrugresistance AT tazadremaylova experienceofusingbedaquilineinthetreatmentofpulmonarytuberculosispatientswithmultipleandextensivedrugresistance |