Immunohistochemical assessment of possible anticancer effect mechanisms of 2-(6,8-dimethyl-5-nitro-4-chloroquinoline-2-yl)- 5,6,7-trichloro-1,3-tropolone in PDX models of lung cancer

Immunohistochemical assessment of possible anticancer effect mechanisms of 2-(6,8-dimethyl-5-nitro-4-chloroquinoline-2-yl)- 5,6,7-trichloro-1,3-tropolone in PDX models of lung cancer

Purpose of the study. Evaluation of the expression of immunohistochemical tumor markers Ki-67, b-catenin, Bcl-2, P53, connexin 32 and connexin 43 when using 2-(6,8-dimethyl-5-nitro-4-chloroquinoline-2-yl)-5,6,7-trichloro-1,3-tropolone in mice with xenographs of squamous cell lung cancer.Materials an...

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Main Authors: E. F. Komarova, E. A. Lukbanova, E. A. Dzhenkova, A. S. Goncharova, E. V. Zaikina, S. V. Gurova, A. V. Galina, L. K. Kurbanova, M. V. Mindar, D. V. Khodakova, M. S. Gusareva, M. S. Zinkovich
Format: Article
Language:Russian
Published: ANO "Perspective of oncology" 2023-03-01
Series:Южно-Российский онкологический журнал
Subjects:
2-(6,8-dimethyl-5-nitro-4-chloroquinoline-2-yl)-5,6,7-trichloro-1,3-tropolone
squamous cell lung cancer
pdx, ki-67
b-catenin, bcl-2, p53
connexin 32 and connexin 43
apoptosis
Online Access:https://www.cancersp.com/jour/article/view/195
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