Assessing the Risk Factors for Refractory Eosinophilic Esophagitis in Children and Adults
Background. Up to one-third of the patients suffering from eosinophilic esophagitis (EoE) present a refractory form, as defined by nonresponsiveness in clinical, endoscopic, or histological assessment after first-line therapy. Several studies recently investigated which factors can influence the dev...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2019/1654543 |
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| author | Erminia Ridolo Irene Martignago Irene Pellicelli Cristoforo Incorvaia |
| author_facet | Erminia Ridolo Irene Martignago Irene Pellicelli Cristoforo Incorvaia |
| author_sort | Erminia Ridolo |
| collection | DOAJ |
| description | Background. Up to one-third of the patients suffering from eosinophilic esophagitis (EoE) present a refractory form, as defined by nonresponsiveness in clinical, endoscopic, or histological assessment after first-line therapy. Several studies recently investigated which factors can influence the development of this disease, but very few analyzed the factors underlying refractory EoE. Methods. Medical charts of patients affected by EoE were retrospectively evaluated. Phenotyping of patients was conducted according to demographic, clinical, histological, and treatment variables. Then, patients were divided into responder and nonresponder to therapy and distinguished among children and adults. Results. Forty-five children and 35 adult EoE patients were included. In the pediatric population, female sex (p<0.05) and a higher score of visual analogue scale (VAS) at the follow-up visit (p=0.02) were significantly associated to the risk of refractory EoE. Among adults, statistical significance was reached for years of follow-up (p=0.001), diagnostic delay (p=0.03), use of antibiotics during infancy (p=0.01), and food allergy (p=0.04). Conclusions. Our study highlighted female sex and a higher VAS score at the time of follow-up visits as risk factors for refractory EoE in children, while the risk factors in adults were identified as fewer years of follow-up, greater diagnostic delay, use of antibiotics during infancy, and food allergy. |
| format | Article |
| id | doaj-art-9b3802ec03464c7bb21523b839a1af39 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-9b3802ec03464c7bb21523b839a1af392025-02-03T05:46:31ZengWileyGastroenterology Research and Practice1687-61211687-630X2019-01-01201910.1155/2019/16545431654543Assessing the Risk Factors for Refractory Eosinophilic Esophagitis in Children and AdultsErminia Ridolo0Irene Martignago1Irene Pellicelli2Cristoforo Incorvaia3Department of Medicine and Surgery, University of Parma, Parma, ItalyUOSD Allergology, ULSS 1 Dolomiti, S. Maria del Prato Hospital, Feltre, ItalyDepartment of Medicine and Surgery, University of Parma, Parma, ItalyCardiac/Pulmonary Rehabilitation, ASST Pini/CTO, Milan, ItalyBackground. Up to one-third of the patients suffering from eosinophilic esophagitis (EoE) present a refractory form, as defined by nonresponsiveness in clinical, endoscopic, or histological assessment after first-line therapy. Several studies recently investigated which factors can influence the development of this disease, but very few analyzed the factors underlying refractory EoE. Methods. Medical charts of patients affected by EoE were retrospectively evaluated. Phenotyping of patients was conducted according to demographic, clinical, histological, and treatment variables. Then, patients were divided into responder and nonresponder to therapy and distinguished among children and adults. Results. Forty-five children and 35 adult EoE patients were included. In the pediatric population, female sex (p<0.05) and a higher score of visual analogue scale (VAS) at the follow-up visit (p=0.02) were significantly associated to the risk of refractory EoE. Among adults, statistical significance was reached for years of follow-up (p=0.001), diagnostic delay (p=0.03), use of antibiotics during infancy (p=0.01), and food allergy (p=0.04). Conclusions. Our study highlighted female sex and a higher VAS score at the time of follow-up visits as risk factors for refractory EoE in children, while the risk factors in adults were identified as fewer years of follow-up, greater diagnostic delay, use of antibiotics during infancy, and food allergy.http://dx.doi.org/10.1155/2019/1654543 |
| spellingShingle | Erminia Ridolo Irene Martignago Irene Pellicelli Cristoforo Incorvaia Assessing the Risk Factors for Refractory Eosinophilic Esophagitis in Children and Adults Gastroenterology Research and Practice |
| title | Assessing the Risk Factors for Refractory Eosinophilic Esophagitis in Children and Adults |
| title_full | Assessing the Risk Factors for Refractory Eosinophilic Esophagitis in Children and Adults |
| title_fullStr | Assessing the Risk Factors for Refractory Eosinophilic Esophagitis in Children and Adults |
| title_full_unstemmed | Assessing the Risk Factors for Refractory Eosinophilic Esophagitis in Children and Adults |
| title_short | Assessing the Risk Factors for Refractory Eosinophilic Esophagitis in Children and Adults |
| title_sort | assessing the risk factors for refractory eosinophilic esophagitis in children and adults |
| url | http://dx.doi.org/10.1155/2019/1654543 |
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