Unraveling the Potential of SGK1 in Osteoporosis: From Molecular Mechanisms to Therapeutic Targets
Osteoporosis (OP) is a prevalent metabolic bone disease, with several million cases of fractures resulting from osteoporosis worldwide each year. This phenomenon contributes to a substantial increase in direct medical expenditures and poses a considerable socioeconomic burden. Despite its prevalence...
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MDPI AG
2025-05-01
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| author | Fei Yang Changshun Chen Rongjin Chen Chenghui Yang Zirui Liu Lei Wen Hefang Xiao Bin Geng Yayi Xia |
| author_facet | Fei Yang Changshun Chen Rongjin Chen Chenghui Yang Zirui Liu Lei Wen Hefang Xiao Bin Geng Yayi Xia |
| author_sort | Fei Yang |
| collection | DOAJ |
| description | Osteoporosis (OP) is a prevalent metabolic bone disease, with several million cases of fractures resulting from osteoporosis worldwide each year. This phenomenon contributes to a substantial increase in direct medical expenditures and poses a considerable socioeconomic burden. Despite its prevalence, our understanding of the underlying mechanisms remains limited. Recent studies have demonstrated the involvement of serum glucocorticoid-regulated protein kinase 1 (SGK1) in multiple signaling pathways that regulate bone metabolism and its significant role in the development of osteoporosis. Therefore, it is of great significance to deeply explore the mechanism of SGK1 in osteoporosis and its therapeutic potential. In this paper, we present a comprehensive review of the structure and activation mechanism of SGK1, its biological function, the role of SGK1 in different types of osteoporosis, and the inhibitors of SGK1. The aim is to comprehensively assess the latest research progress with regards to SGK1’s role in osteoporosis, clarify its role in the regulation of bone metabolism and its potential as a therapeutic target, and lay the foundation for the development of novel therapeutic strategies and personalized treatment in the future. Furthermore, by thoroughly examining the interactions between SGK1 and other molecules or signaling pathways, potential biomarkers may be identified, thereby enhancing the efficacy of early screening and intervention for osteoporosis. |
| format | Article |
| id | doaj-art-9b27e33c4cb84b448d0ee9a6bead5c7d |
| institution | OA Journals |
| issn | 2218-273X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-9b27e33c4cb84b448d0ee9a6bead5c7d2025-08-20T01:56:14ZengMDPI AGBiomolecules2218-273X2025-05-0115568610.3390/biom15050686Unraveling the Potential of SGK1 in Osteoporosis: From Molecular Mechanisms to Therapeutic TargetsFei Yang0Changshun Chen1Rongjin Chen2Chenghui Yang3Zirui Liu4Lei Wen5Hefang Xiao6Bin Geng7Yayi Xia8Department of Orthopaedics, Lanzhou University Second Hospital, Lanzhou 730030, ChinaDepartment of Orthopaedics, Lanzhou University Second Hospital, Lanzhou 730030, ChinaDepartment of Orthopaedics, Lanzhou University Second Hospital, Lanzhou 730030, ChinaDepartment of Orthopaedics, Lanzhou University Second Hospital, Lanzhou 730030, ChinaDepartment of Orthopaedics, Lanzhou University Second Hospital, Lanzhou 730030, ChinaDepartment of Orthopaedics, Lanzhou University Second Hospital, Lanzhou 730030, ChinaDepartment of Orthopaedics, Lanzhou University Second Hospital, Lanzhou 730030, ChinaDepartment of Orthopaedics, Lanzhou University Second Hospital, Lanzhou 730030, ChinaDepartment of Orthopaedics, Lanzhou University Second Hospital, Lanzhou 730030, ChinaOsteoporosis (OP) is a prevalent metabolic bone disease, with several million cases of fractures resulting from osteoporosis worldwide each year. This phenomenon contributes to a substantial increase in direct medical expenditures and poses a considerable socioeconomic burden. Despite its prevalence, our understanding of the underlying mechanisms remains limited. Recent studies have demonstrated the involvement of serum glucocorticoid-regulated protein kinase 1 (SGK1) in multiple signaling pathways that regulate bone metabolism and its significant role in the development of osteoporosis. Therefore, it is of great significance to deeply explore the mechanism of SGK1 in osteoporosis and its therapeutic potential. In this paper, we present a comprehensive review of the structure and activation mechanism of SGK1, its biological function, the role of SGK1 in different types of osteoporosis, and the inhibitors of SGK1. The aim is to comprehensively assess the latest research progress with regards to SGK1’s role in osteoporosis, clarify its role in the regulation of bone metabolism and its potential as a therapeutic target, and lay the foundation for the development of novel therapeutic strategies and personalized treatment in the future. Furthermore, by thoroughly examining the interactions between SGK1 and other molecules or signaling pathways, potential biomarkers may be identified, thereby enhancing the efficacy of early screening and intervention for osteoporosis.https://www.mdpi.com/2218-273X/15/5/686osteoporosisSGK1protein kinasemetabolic bone diseasetherapeutic strategies |
| spellingShingle | Fei Yang Changshun Chen Rongjin Chen Chenghui Yang Zirui Liu Lei Wen Hefang Xiao Bin Geng Yayi Xia Unraveling the Potential of SGK1 in Osteoporosis: From Molecular Mechanisms to Therapeutic Targets Biomolecules osteoporosis SGK1 protein kinase metabolic bone disease therapeutic strategies |
| title | Unraveling the Potential of SGK1 in Osteoporosis: From Molecular Mechanisms to Therapeutic Targets |
| title_full | Unraveling the Potential of SGK1 in Osteoporosis: From Molecular Mechanisms to Therapeutic Targets |
| title_fullStr | Unraveling the Potential of SGK1 in Osteoporosis: From Molecular Mechanisms to Therapeutic Targets |
| title_full_unstemmed | Unraveling the Potential of SGK1 in Osteoporosis: From Molecular Mechanisms to Therapeutic Targets |
| title_short | Unraveling the Potential of SGK1 in Osteoporosis: From Molecular Mechanisms to Therapeutic Targets |
| title_sort | unraveling the potential of sgk1 in osteoporosis from molecular mechanisms to therapeutic targets |
| topic | osteoporosis SGK1 protein kinase metabolic bone disease therapeutic strategies |
| url | https://www.mdpi.com/2218-273X/15/5/686 |
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