BIOCHEMICAL ANALYSIS OF SALIVARY MALONDIALDEHYDE LEVELS IN 14-15-YEAR-OLD ADOLESCENTS WITH ORAL PATHOLOGY
Elevated oxidative stress can contribute to inflammation, which is believed to play a role in oral manifestation such as GT or AU mainly in ages of 14 and 15 years. During this period, children are undergoing various physical, mental, and emotional changes due to their transition from childhood to a...
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Romanian Society of Oral Rehabilitation
2024-12-01
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| Series: | Romanian Journal of Oral Rehabilitation |
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| Online Access: | https://rjor.ro/biochemical-analysis-of-salivary-malondialdehyde-levels-in-14-15-year-old-adolescents-with-oral-pathology/ |
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| author | Alexandra Mihaela Stoica Oana Elena Stoica Alexandru Vlasa Cristina Ioana Bica Liana Bereșescu Zsuzsanna Bardocz-Veres Monica Dana Monea |
| author_facet | Alexandra Mihaela Stoica Oana Elena Stoica Alexandru Vlasa Cristina Ioana Bica Liana Bereșescu Zsuzsanna Bardocz-Veres Monica Dana Monea |
| author_sort | Alexandra Mihaela Stoica |
| collection | DOAJ |
| description | Elevated oxidative stress can contribute to inflammation, which is believed to play a role in oral manifestation such as GT or AU mainly in ages of 14 and 15 years. During this period, children are undergoing various physical, mental, and emotional changes due to their transition from childhood to adolescence. As GT or AU are more frequent in this ages, our aim of the study was to determine if there is any positive correlation between the salivary levels of Malondialdehyde (MDA) considered a biomarker of oxidative stress and the severity and progression of mucosal pathology. Materials and methods: Using the High-Performance Liquid Chromatography (HPLC) technique, we assessed the MDA concentrations which were statistically evaluated and compared between a study group of participants diagnosed with GT or AU and a control group of healthy age-matched subjects. Results: The study group has a significantly higher mean value (26.285) compared to the control group (21.425), with a p-value of 0.0017, indicating a statistically significant difference between the two groups. However, the gender distribution between the study group (51.4% female, 48.5% male) and the control group (52% female, 48% male) does not significantly differ, as evidenced by a p-value of 0.9016. Conclusions: The levels of salivary MDA were higher in the study groups with GT and AU, with statistically significant differences (p<0.05) compared to healthy subjects, which questions weather oxidative stress might be linked to geographic tongue pathogenesis or aphthous ulcers. |
| format | Article |
| id | doaj-art-9b2440855ed6412cb480b876acfd7afc |
| institution | Kabale University |
| issn | 2066-7000 2601-4661 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Romanian Society of Oral Rehabilitation |
| record_format | Article |
| series | Romanian Journal of Oral Rehabilitation |
| spelling | doaj-art-9b2440855ed6412cb480b876acfd7afc2025-01-21T12:33:10ZengRomanian Society of Oral RehabilitationRomanian Journal of Oral Rehabilitation2066-70002601-46612024-12-0116415416310.62610/RJOR.2024.4.16.15BIOCHEMICAL ANALYSIS OF SALIVARY MALONDIALDEHYDE LEVELS IN 14-15-YEAR-OLD ADOLESCENTS WITH ORAL PATHOLOGYAlexandra Mihaela StoicaOana Elena StoicaAlexandru VlasaCristina Ioana BicaLiana BereșescuZsuzsanna Bardocz-VeresMonica Dana MoneaElevated oxidative stress can contribute to inflammation, which is believed to play a role in oral manifestation such as GT or AU mainly in ages of 14 and 15 years. During this period, children are undergoing various physical, mental, and emotional changes due to their transition from childhood to adolescence. As GT or AU are more frequent in this ages, our aim of the study was to determine if there is any positive correlation between the salivary levels of Malondialdehyde (MDA) considered a biomarker of oxidative stress and the severity and progression of mucosal pathology. Materials and methods: Using the High-Performance Liquid Chromatography (HPLC) technique, we assessed the MDA concentrations which were statistically evaluated and compared between a study group of participants diagnosed with GT or AU and a control group of healthy age-matched subjects. Results: The study group has a significantly higher mean value (26.285) compared to the control group (21.425), with a p-value of 0.0017, indicating a statistically significant difference between the two groups. However, the gender distribution between the study group (51.4% female, 48.5% male) and the control group (52% female, 48% male) does not significantly differ, as evidenced by a p-value of 0.9016. Conclusions: The levels of salivary MDA were higher in the study groups with GT and AU, with statistically significant differences (p<0.05) compared to healthy subjects, which questions weather oxidative stress might be linked to geographic tongue pathogenesis or aphthous ulcers.https://rjor.ro/biochemical-analysis-of-salivary-malondialdehyde-levels-in-14-15-year-old-adolescents-with-oral-pathology/geographic tonguemalondialdehydehplc |
| spellingShingle | Alexandra Mihaela Stoica Oana Elena Stoica Alexandru Vlasa Cristina Ioana Bica Liana Bereșescu Zsuzsanna Bardocz-Veres Monica Dana Monea BIOCHEMICAL ANALYSIS OF SALIVARY MALONDIALDEHYDE LEVELS IN 14-15-YEAR-OLD ADOLESCENTS WITH ORAL PATHOLOGY Romanian Journal of Oral Rehabilitation geographic tongue malondialdehyde hplc |
| title | BIOCHEMICAL ANALYSIS OF SALIVARY MALONDIALDEHYDE LEVELS IN 14-15-YEAR-OLD ADOLESCENTS WITH ORAL PATHOLOGY |
| title_full | BIOCHEMICAL ANALYSIS OF SALIVARY MALONDIALDEHYDE LEVELS IN 14-15-YEAR-OLD ADOLESCENTS WITH ORAL PATHOLOGY |
| title_fullStr | BIOCHEMICAL ANALYSIS OF SALIVARY MALONDIALDEHYDE LEVELS IN 14-15-YEAR-OLD ADOLESCENTS WITH ORAL PATHOLOGY |
| title_full_unstemmed | BIOCHEMICAL ANALYSIS OF SALIVARY MALONDIALDEHYDE LEVELS IN 14-15-YEAR-OLD ADOLESCENTS WITH ORAL PATHOLOGY |
| title_short | BIOCHEMICAL ANALYSIS OF SALIVARY MALONDIALDEHYDE LEVELS IN 14-15-YEAR-OLD ADOLESCENTS WITH ORAL PATHOLOGY |
| title_sort | biochemical analysis of salivary malondialdehyde levels in 14 15 year old adolescents with oral pathology |
| topic | geographic tongue malondialdehyde hplc |
| url | https://rjor.ro/biochemical-analysis-of-salivary-malondialdehyde-levels-in-14-15-year-old-adolescents-with-oral-pathology/ |
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