A Rare Case of Melanosis of the Hard Palate Mucosa in a Patient with Chronic Myeloid Leukemia
Imatinib Mesylate, also known as Gleevec or ST1-571, is a tyrosine-kinase inhibitor used as the gold standard medication for the chronic myeloid leukemia (CML); Imatinib has indeed deeply revolutionized the CML therapy allowing most patients to have a good quality of life. Despite its beneficial eff...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2015/817094 |
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| author | Umberto Romeo Gaspare Palaia Paolo Junior Fantozzi Gianluca Tenore Daniela Bosco |
| author_facet | Umberto Romeo Gaspare Palaia Paolo Junior Fantozzi Gianluca Tenore Daniela Bosco |
| author_sort | Umberto Romeo |
| collection | DOAJ |
| description | Imatinib Mesylate, also known as Gleevec or ST1-571, is a tyrosine-kinase inhibitor used as the gold standard medication for the chronic myeloid leukemia (CML); Imatinib has indeed deeply revolutionized the CML therapy allowing most patients to have a good quality of life. Despite its beneficial effects, Imatinib has significant side effects such as mucosal pigmentation. A 72-year-old female having an Imatinib induced mucosal pigmentation is presented: she has been treated with Imatinib since 2003 and only in 2014 discovered, during a routine dental visit, having a pigmented lesion on her hard palate mucosa. Histopathologically, the lesion shows the deposition of fine dark brown spherical bodies within the lamina propria and cloaked in between the collagen fibers. There was no sign of inflammation, hyperplasia, or hemorrhage in the tissue. |
| format | Article |
| id | doaj-art-9b2237fcfe434a9db6b3aed9bccde6bf |
| institution | Kabale University |
| issn | 2090-6447 2090-6455 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Dentistry |
| spelling | doaj-art-9b2237fcfe434a9db6b3aed9bccde6bf2025-02-03T01:01:47ZengWileyCase Reports in Dentistry2090-64472090-64552015-01-01201510.1155/2015/817094817094A Rare Case of Melanosis of the Hard Palate Mucosa in a Patient with Chronic Myeloid LeukemiaUmberto Romeo0Gaspare Palaia1Paolo Junior Fantozzi2Gianluca Tenore3Daniela Bosco4Department of Oral and Maxillofacial Sciences, “Sapienza” University of Rome, Via Caserta 6, 00161 Rome, ItalyDepartment of Oral and Maxillofacial Sciences, “Sapienza” University of Rome, Via Caserta 6, 00161 Rome, ItalyDepartment of Oral and Maxillofacial Sciences, “Sapienza” University of Rome, Via Caserta 6, 00161 Rome, ItalyDepartment of Oral and Maxillofacial Sciences, “Sapienza” University of Rome, Via Caserta 6, 00161 Rome, ItalyDepartment of Radiological, Oncological and Anatomo-Pathological Sciences, “Sapienza” University of Rome, Viale Regina Elena 324, 00161 Rome, ItalyImatinib Mesylate, also known as Gleevec or ST1-571, is a tyrosine-kinase inhibitor used as the gold standard medication for the chronic myeloid leukemia (CML); Imatinib has indeed deeply revolutionized the CML therapy allowing most patients to have a good quality of life. Despite its beneficial effects, Imatinib has significant side effects such as mucosal pigmentation. A 72-year-old female having an Imatinib induced mucosal pigmentation is presented: she has been treated with Imatinib since 2003 and only in 2014 discovered, during a routine dental visit, having a pigmented lesion on her hard palate mucosa. Histopathologically, the lesion shows the deposition of fine dark brown spherical bodies within the lamina propria and cloaked in between the collagen fibers. There was no sign of inflammation, hyperplasia, or hemorrhage in the tissue.http://dx.doi.org/10.1155/2015/817094 |
| spellingShingle | Umberto Romeo Gaspare Palaia Paolo Junior Fantozzi Gianluca Tenore Daniela Bosco A Rare Case of Melanosis of the Hard Palate Mucosa in a Patient with Chronic Myeloid Leukemia Case Reports in Dentistry |
| title | A Rare Case of Melanosis of the Hard Palate Mucosa in a Patient with Chronic Myeloid Leukemia |
| title_full | A Rare Case of Melanosis of the Hard Palate Mucosa in a Patient with Chronic Myeloid Leukemia |
| title_fullStr | A Rare Case of Melanosis of the Hard Palate Mucosa in a Patient with Chronic Myeloid Leukemia |
| title_full_unstemmed | A Rare Case of Melanosis of the Hard Palate Mucosa in a Patient with Chronic Myeloid Leukemia |
| title_short | A Rare Case of Melanosis of the Hard Palate Mucosa in a Patient with Chronic Myeloid Leukemia |
| title_sort | rare case of melanosis of the hard palate mucosa in a patient with chronic myeloid leukemia |
| url | http://dx.doi.org/10.1155/2015/817094 |
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