The impact of the National Syphilis Prevention Program on the prevalence of syphilis among people living with HIV in China: a systematic review and meta‐analysis
Abstract Introduction In 2010, China launched the 10‐year National Syphilis Prevention and Control Program to curb the spread of syphilis by integrating syphilis screening and treatment with HIV services. Herein, we aimed to evaluate changes in the prevalence of syphilis among people living with HIV...
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2025-01-01
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| Series: | Journal of the International AIDS Society |
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| Online Access: | https://doi.org/10.1002/jia2.26408 |
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| author | Qingling Zeng Yuhui Yang Limin Zhang Jiangyu Yan Jian Wang Jingmin Nie Qingmei Wang Yu Luo Gaoming Li |
| author_facet | Qingling Zeng Yuhui Yang Limin Zhang Jiangyu Yan Jian Wang Jingmin Nie Qingmei Wang Yu Luo Gaoming Li |
| author_sort | Qingling Zeng |
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| description | Abstract Introduction In 2010, China launched the 10‐year National Syphilis Prevention and Control Program to curb the spread of syphilis by integrating syphilis screening and treatment with HIV services. Herein, we aimed to evaluate changes in the prevalence of syphilis among people living with HIV (PLHIV) in China. Methods We conducted this systematic review and meta‐analysis by searching the PubMed, Embase, Web of Science, China Biomedical Literature, China National Knowledge Infrastructure, Wanfang and CQVIP databases from inception to 1 June 2024 to obtain relevant articles. A total of 75 studies were ultimately included. We used a DerSimonian‒Laird random effects model to estimate the prevalence and 95% confidence interval of syphilis among PLHIV. Results The overall prevalence of syphilis among PLHIV in China was 18.6% (95% CI 16.5–21.0). Regional differences (R2 = 15.29%) were observed in the prevalence rates: 22.2% (18.9–25.8) in the eastern region, 19.0% (15.1–23.8) in the central region and 14.0% (11.1–17.5) in the western region. The prevalence decreased from 22.8% (18.4–27.9) before 2010 to 17.0% (14.6–19.6) in 2010 and thereafter (R2 = 5.82%). Among PLHIV via homosexual transmission, the prevalence of syphilis was 24.9% (21.3–28.9), which significantly declined from 33.8% (27.5–40.8) to 21.4% (18.3–24.9) in 2010 and thereafter (R2 = 22.35%). The prevalence of syphilis was significantly higher in men living with HIV than in women living with HIV (pooled odds ratio 1.67, 95% CI 1.29–2.15), with the highest prevalence in the eastern region (2.55, 95% CI 1.80–3.59). Discussion The prevalence of syphilis among PLHIV, particularly in cases of homosexual transmission, has declined. There was a correlation between the prevalence of syphilis and regional economic conditions, with a greater burden in developed eastern coastal areas. Additionally, the risk of syphilis differed across sexes, with men living with HIV having a higher risk. Conclusions There has been preliminary success in the control of syphilis among PLHIV, but there is still a long way to go to meet the WHO's 2030 syphilis prevention and control goal. Syphilis prevention measures should be integrated into broader health policies and development plans, particularly in high‐burden regions and populations. |
| format | Article |
| id | doaj-art-9b219e20f09840699a4e44251593c162 |
| institution | Kabale University |
| issn | 1758-2652 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
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| spelling | doaj-art-9b219e20f09840699a4e44251593c1622025-01-24T08:18:07ZengWileyJournal of the International AIDS Society1758-26522025-01-01281n/an/a10.1002/jia2.26408The impact of the National Syphilis Prevention Program on the prevalence of syphilis among people living with HIV in China: a systematic review and meta‐analysisQingling Zeng0Yuhui Yang1Limin Zhang2Jiangyu Yan3Jian Wang4Jingmin Nie5Qingmei Wang6Yu Luo7Gaoming Li8Department of CardiovascularXinqiao HospitalArmy Medical UniversityChongqingChinaSchool of NursingArmy Medical UniversityChongqingChinaDepartment of CardiovascularXinqiao HospitalArmy Medical UniversityChongqingChinaClinical Research CenterChongqing Public Health Medical CenterChongqingChinaCenter for Disease Control and Prevention of Central Theater Command of Chinese People's Liberation ArmyBeijing ChinaDepartment of Infectious DiseasePeople's Hospital of Chongqing Banan DistrictChongqingChinaDepartment of Nursing, The First Medical CenterChinese PLA General HospitalBeijingChinaSchool of NursingArmy Medical UniversityChongqingChinaCenter for Disease Control and Prevention of Central Theater Command of Chinese People's Liberation ArmyBeijing ChinaAbstract Introduction In 2010, China launched the 10‐year National Syphilis Prevention and Control Program to curb the spread of syphilis by integrating syphilis screening and treatment with HIV services. Herein, we aimed to evaluate changes in the prevalence of syphilis among people living with HIV (PLHIV) in China. Methods We conducted this systematic review and meta‐analysis by searching the PubMed, Embase, Web of Science, China Biomedical Literature, China National Knowledge Infrastructure, Wanfang and CQVIP databases from inception to 1 June 2024 to obtain relevant articles. A total of 75 studies were ultimately included. We used a DerSimonian‒Laird random effects model to estimate the prevalence and 95% confidence interval of syphilis among PLHIV. Results The overall prevalence of syphilis among PLHIV in China was 18.6% (95% CI 16.5–21.0). Regional differences (R2 = 15.29%) were observed in the prevalence rates: 22.2% (18.9–25.8) in the eastern region, 19.0% (15.1–23.8) in the central region and 14.0% (11.1–17.5) in the western region. The prevalence decreased from 22.8% (18.4–27.9) before 2010 to 17.0% (14.6–19.6) in 2010 and thereafter (R2 = 5.82%). Among PLHIV via homosexual transmission, the prevalence of syphilis was 24.9% (21.3–28.9), which significantly declined from 33.8% (27.5–40.8) to 21.4% (18.3–24.9) in 2010 and thereafter (R2 = 22.35%). The prevalence of syphilis was significantly higher in men living with HIV than in women living with HIV (pooled odds ratio 1.67, 95% CI 1.29–2.15), with the highest prevalence in the eastern region (2.55, 95% CI 1.80–3.59). Discussion The prevalence of syphilis among PLHIV, particularly in cases of homosexual transmission, has declined. There was a correlation between the prevalence of syphilis and regional economic conditions, with a greater burden in developed eastern coastal areas. Additionally, the risk of syphilis differed across sexes, with men living with HIV having a higher risk. Conclusions There has been preliminary success in the control of syphilis among PLHIV, but there is still a long way to go to meet the WHO's 2030 syphilis prevention and control goal. Syphilis prevention measures should be integrated into broader health policies and development plans, particularly in high‐burden regions and populations.https://doi.org/10.1002/jia2.26408syphilisHIVmeta‐analysiscoinfectionsexually transmitted infections/diseasesChina |
| spellingShingle | Qingling Zeng Yuhui Yang Limin Zhang Jiangyu Yan Jian Wang Jingmin Nie Qingmei Wang Yu Luo Gaoming Li The impact of the National Syphilis Prevention Program on the prevalence of syphilis among people living with HIV in China: a systematic review and meta‐analysis Journal of the International AIDS Society syphilis HIV meta‐analysis coinfection sexually transmitted infections/diseases China |
| title | The impact of the National Syphilis Prevention Program on the prevalence of syphilis among people living with HIV in China: a systematic review and meta‐analysis |
| title_full | The impact of the National Syphilis Prevention Program on the prevalence of syphilis among people living with HIV in China: a systematic review and meta‐analysis |
| title_fullStr | The impact of the National Syphilis Prevention Program on the prevalence of syphilis among people living with HIV in China: a systematic review and meta‐analysis |
| title_full_unstemmed | The impact of the National Syphilis Prevention Program on the prevalence of syphilis among people living with HIV in China: a systematic review and meta‐analysis |
| title_short | The impact of the National Syphilis Prevention Program on the prevalence of syphilis among people living with HIV in China: a systematic review and meta‐analysis |
| title_sort | impact of the national syphilis prevention program on the prevalence of syphilis among people living with hiv in china a systematic review and meta analysis |
| topic | syphilis HIV meta‐analysis coinfection sexually transmitted infections/diseases China |
| url | https://doi.org/10.1002/jia2.26408 |
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