Enhanced construction of a bivalent adenovirus-based vaccine for preventing childhood pathogens: Human respiratory syncytial virus and norovirus

Enhanced construction of a bivalent adenovirus-based vaccine for preventing childhood pathogens: Human respiratory syncytial virus and norovirus

To impede the spread of respiratory syncytial virus (RSV) and norovirus (NoV) in children, we developed novel recombinant adenoviruses expressing RSV fusion (F) and NoV VP1 proteins driven by different promoter elements (EF1α, SV40, and CMV), resulting in Ad-F/E/NoV, Ad-F/S/NoV, and Ad-F/C/NoV, resp...

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Bibliographic Details
Main Authors: Ying-Chin Chen, Nai-Hsiang Chung, Yu-Ching Lin, Shu-Ling Yu, Chia-Chyi Liu, Yen-Hung Chow
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:SLAS Technology
Subjects:
RSV
Norovirus
Adenovirus
Vaccine
Online Access:http://www.sciencedirect.com/science/article/pii/S2472630325000135
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