RNA N6-Methyladenosine Modifications and the Immune Response
N6-methyladenosine (m6A) is the most important modification of messenger RNAs (mRNAs) and long noncoding RNAs (lncRNAs) in higher eukaryotes. Modulation of m6A modifications relies on methyltransferases and demethylases. The discovery of binding proteins confirms that the m6A modification has a wide...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2020/6327614 |
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| _version_ | 1832550437047238656 |
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| author | Ya-Nan Wang Chen-Yang Yu Hong-Zhong Jin |
| author_facet | Ya-Nan Wang Chen-Yang Yu Hong-Zhong Jin |
| author_sort | Ya-Nan Wang |
| collection | DOAJ |
| description | N6-methyladenosine (m6A) is the most important modification of messenger RNAs (mRNAs) and long noncoding RNAs (lncRNAs) in higher eukaryotes. Modulation of m6A modifications relies on methyltransferases and demethylases. The discovery of binding proteins confirms that the m6A modification has a wide range of biological effects and significance at the molecular, cellular, and physiological levels. In recent years, techniques for investigating m6A modifications of RNA have developed rapidly. This article reviews the biological significance of RNA m6A modifications in the innate immune response, adaptive immune response, and viral infection. |
| format | Article |
| id | doaj-art-9b1546926652471aa6ba17a18aa33002 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-9b1546926652471aa6ba17a18aa330022025-02-03T06:06:43ZengWileyJournal of Immunology Research2314-88612314-71562020-01-01202010.1155/2020/63276146327614RNA N6-Methyladenosine Modifications and the Immune ResponseYa-Nan Wang0Chen-Yang Yu1Hong-Zhong Jin2Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy Medical Science and Peking Union Medical College, Beijing, ChinaDepartment of Dermatology, Peking Union Medical College Hospital, Chinese Academy Medical Science and Peking Union Medical College, Beijing, ChinaDepartment of Dermatology, Peking Union Medical College Hospital, Chinese Academy Medical Science and Peking Union Medical College, Beijing, ChinaN6-methyladenosine (m6A) is the most important modification of messenger RNAs (mRNAs) and long noncoding RNAs (lncRNAs) in higher eukaryotes. Modulation of m6A modifications relies on methyltransferases and demethylases. The discovery of binding proteins confirms that the m6A modification has a wide range of biological effects and significance at the molecular, cellular, and physiological levels. In recent years, techniques for investigating m6A modifications of RNA have developed rapidly. This article reviews the biological significance of RNA m6A modifications in the innate immune response, adaptive immune response, and viral infection.http://dx.doi.org/10.1155/2020/6327614 |
| spellingShingle | Ya-Nan Wang Chen-Yang Yu Hong-Zhong Jin RNA N6-Methyladenosine Modifications and the Immune Response Journal of Immunology Research |
| title | RNA N6-Methyladenosine Modifications and the Immune Response |
| title_full | RNA N6-Methyladenosine Modifications and the Immune Response |
| title_fullStr | RNA N6-Methyladenosine Modifications and the Immune Response |
| title_full_unstemmed | RNA N6-Methyladenosine Modifications and the Immune Response |
| title_short | RNA N6-Methyladenosine Modifications and the Immune Response |
| title_sort | rna n6 methyladenosine modifications and the immune response |
| url | http://dx.doi.org/10.1155/2020/6327614 |
| work_keys_str_mv | AT yananwang rnan6methyladenosinemodificationsandtheimmuneresponse AT chenyangyu rnan6methyladenosinemodificationsandtheimmuneresponse AT hongzhongjin rnan6methyladenosinemodificationsandtheimmuneresponse |