The Function of T Follicular Helper Cells in the Autoimmune Liver Diseases
T follicular helper (TFH) cells are recognized as a subtype of T cells that are involved in the germinal center formation and B cell development. When dysregulated, TFH cells may represent an important mechanism that contributes to a heightened humoral response and autoantibody production in autoimm...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2020/5679254 |
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| _version_ | 1832550923478499328 |
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| author | Lin Li Panyang Xu Qi Zhou Jiancheng Xu |
| author_facet | Lin Li Panyang Xu Qi Zhou Jiancheng Xu |
| author_sort | Lin Li |
| collection | DOAJ |
| description | T follicular helper (TFH) cells are recognized as a subtype of T cells that are involved in the germinal center formation and B cell development. When dysregulated, TFH cells may represent an important mechanism that contributes to a heightened humoral response and autoantibody production in autoimmune liver diseases (AILDs). TFH cells participate in the immune response associated with AILDs by expressing surface receptors such as programmed cell death protein-1, C-X-C motif chemokine receptor 5, and inducible T cell costimulators, as well as cytokines such as interleukin-21. TFH cells also downregulate chemokine (C-C motif) receptor 7 and promote the dysregulation of the T follicular regulatory/TFH axis. This review highlights the importance of TFH cells in AILDs. |
| format | Article |
| id | doaj-art-9b0a862ceef146699014eaa05d6f0348 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-9b0a862ceef146699014eaa05d6f03482025-02-03T06:05:29ZengWileyJournal of Immunology Research2314-88612314-71562020-01-01202010.1155/2020/56792545679254The Function of T Follicular Helper Cells in the Autoimmune Liver DiseasesLin Li0Panyang Xu1Qi Zhou2Jiancheng Xu3Department of Laboratory Medicine, First Hospital of Jilin University, Changchun 130021, ChinaDepartment of Laboratory Medicine, First Hospital of Jilin University, Changchun 130021, ChinaDepartment of Pediatrics, First Hospital of Jilin University, Changchun 130021, ChinaDepartment of Laboratory Medicine, First Hospital of Jilin University, Changchun 130021, ChinaT follicular helper (TFH) cells are recognized as a subtype of T cells that are involved in the germinal center formation and B cell development. When dysregulated, TFH cells may represent an important mechanism that contributes to a heightened humoral response and autoantibody production in autoimmune liver diseases (AILDs). TFH cells participate in the immune response associated with AILDs by expressing surface receptors such as programmed cell death protein-1, C-X-C motif chemokine receptor 5, and inducible T cell costimulators, as well as cytokines such as interleukin-21. TFH cells also downregulate chemokine (C-C motif) receptor 7 and promote the dysregulation of the T follicular regulatory/TFH axis. This review highlights the importance of TFH cells in AILDs.http://dx.doi.org/10.1155/2020/5679254 |
| spellingShingle | Lin Li Panyang Xu Qi Zhou Jiancheng Xu The Function of T Follicular Helper Cells in the Autoimmune Liver Diseases Journal of Immunology Research |
| title | The Function of T Follicular Helper Cells in the Autoimmune Liver Diseases |
| title_full | The Function of T Follicular Helper Cells in the Autoimmune Liver Diseases |
| title_fullStr | The Function of T Follicular Helper Cells in the Autoimmune Liver Diseases |
| title_full_unstemmed | The Function of T Follicular Helper Cells in the Autoimmune Liver Diseases |
| title_short | The Function of T Follicular Helper Cells in the Autoimmune Liver Diseases |
| title_sort | function of t follicular helper cells in the autoimmune liver diseases |
| url | http://dx.doi.org/10.1155/2020/5679254 |
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