Urinary Macrophage Migration Inhibitory Factor Serves as a Potential Biomarker for Acute Kidney Injury in Patients with Acute Pyelonephritis
Conventional markers of kidney function that are familiar to clinicians, including the serum creatinine and blood urea nitrogen levels, are unable to reveal genuine injury to the kidney, and their use may delay treatment. Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine, an...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/381358 |
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| author | Ming-Yuan Hong Chin-Chung Tseng Chia-Chang Chuang Chia-Ling Chen Sheng-Hsiang Lin Chiou-Feng Lin |
| author_facet | Ming-Yuan Hong Chin-Chung Tseng Chia-Chang Chuang Chia-Ling Chen Sheng-Hsiang Lin Chiou-Feng Lin |
| author_sort | Ming-Yuan Hong |
| collection | DOAJ |
| description | Conventional markers of kidney function that are familiar to clinicians, including the serum creatinine and blood urea nitrogen levels, are unable to reveal genuine injury to the kidney, and their use may delay treatment. Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine, and the predictive role and pathogenic mechanism of MIF deregulation during kidney infections involving acute kidney injury (AKI) are not currently known. In this study, we showed that elevated urinary MIF levels accompanied the development of AKI during kidney infection in patients with acute pyelonephritis (APN). In addition to the MIF level, the urinary levels of interleukin (IL)-1β and kidney injury molecule (KIM)-1 were also upregulated and were positively correlated with the levels of urinary MIF. An elevated urinary MIF level, along with elevated IL-1β and KIM-1 levels, is speculated to be a potential biomarker for the presence of AKI in APN patients. |
| format | Article |
| id | doaj-art-9aff04c4e717436b9142fda2a1bb4884 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-9aff04c4e717436b9142fda2a1bb48842025-02-03T05:46:38ZengWileyMediators of Inflammation0962-93511466-18612012-01-01201210.1155/2012/381358381358Urinary Macrophage Migration Inhibitory Factor Serves as a Potential Biomarker for Acute Kidney Injury in Patients with Acute PyelonephritisMing-Yuan Hong0Chin-Chung Tseng1Chia-Chang Chuang2Chia-Ling Chen3Sheng-Hsiang Lin4Chiou-Feng Lin5Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 701, TaiwanDepartment of Internal Medicine, National Cheng Kung University Hospital, Tainan 704, TaiwanDepartment of Emergency Medicine, National Cheng Kung University Hospital, Tainan 704, TaiwanDepartment of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan 701, TaiwanInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 701, TaiwanInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 701, TaiwanConventional markers of kidney function that are familiar to clinicians, including the serum creatinine and blood urea nitrogen levels, are unable to reveal genuine injury to the kidney, and their use may delay treatment. Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine, and the predictive role and pathogenic mechanism of MIF deregulation during kidney infections involving acute kidney injury (AKI) are not currently known. In this study, we showed that elevated urinary MIF levels accompanied the development of AKI during kidney infection in patients with acute pyelonephritis (APN). In addition to the MIF level, the urinary levels of interleukin (IL)-1β and kidney injury molecule (KIM)-1 were also upregulated and were positively correlated with the levels of urinary MIF. An elevated urinary MIF level, along with elevated IL-1β and KIM-1 levels, is speculated to be a potential biomarker for the presence of AKI in APN patients.http://dx.doi.org/10.1155/2012/381358 |
| spellingShingle | Ming-Yuan Hong Chin-Chung Tseng Chia-Chang Chuang Chia-Ling Chen Sheng-Hsiang Lin Chiou-Feng Lin Urinary Macrophage Migration Inhibitory Factor Serves as a Potential Biomarker for Acute Kidney Injury in Patients with Acute Pyelonephritis Mediators of Inflammation |
| title | Urinary Macrophage Migration Inhibitory Factor Serves as a Potential Biomarker for Acute Kidney Injury in Patients with Acute Pyelonephritis |
| title_full | Urinary Macrophage Migration Inhibitory Factor Serves as a Potential Biomarker for Acute Kidney Injury in Patients with Acute Pyelonephritis |
| title_fullStr | Urinary Macrophage Migration Inhibitory Factor Serves as a Potential Biomarker for Acute Kidney Injury in Patients with Acute Pyelonephritis |
| title_full_unstemmed | Urinary Macrophage Migration Inhibitory Factor Serves as a Potential Biomarker for Acute Kidney Injury in Patients with Acute Pyelonephritis |
| title_short | Urinary Macrophage Migration Inhibitory Factor Serves as a Potential Biomarker for Acute Kidney Injury in Patients with Acute Pyelonephritis |
| title_sort | urinary macrophage migration inhibitory factor serves as a potential biomarker for acute kidney injury in patients with acute pyelonephritis |
| url | http://dx.doi.org/10.1155/2012/381358 |
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