The association between the dietary inflammatory index and multiple myeloma: a case–control study
Abstract The dietary inflammatory index (DII) is a common grading system for diet inflammatory potential. Recent investigations link DII to hematopoietic malignancies. However, the relationship between DII and Multiple myeloma (MM) is unknown. DII and MM were examined in a present case–control study...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-87494-7 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832585793515814912 |
|---|---|
| author | Hoda Zahedi Mohammad-Reza Jowshan Hamid Rasekhi Maryam Amini Omid Sadeghi Mahshid Mehdizadeh Sayeh Parkhideh Moloud Payab Erfan Zamani Mahdi Shadnoush Abbas Hajifathali |
| author_facet | Hoda Zahedi Mohammad-Reza Jowshan Hamid Rasekhi Maryam Amini Omid Sadeghi Mahshid Mehdizadeh Sayeh Parkhideh Moloud Payab Erfan Zamani Mahdi Shadnoush Abbas Hajifathali |
| author_sort | Hoda Zahedi |
| collection | DOAJ |
| description | Abstract The dietary inflammatory index (DII) is a common grading system for diet inflammatory potential. Recent investigations link DII to hematopoietic malignancies. However, the relationship between DII and Multiple myeloma (MM) is unknown. DII and MM were examined in a present case–control study of Iranian adults. This case–controlstudy was conducted on adults aged 20 to 75 years, selecting 149 cases with newly diagnosed multiple myeloma and 359 healthy individuals. Dietary assessment was conducted using a validated semi-quantitative food frequency questionnaire (FFQ) including 154 items, and energy-adjusted DII scores were calculated to determine the level of inflammatory properties in each individual’s diet using 29 dietary parameters. Conditional logistic regression models were used to investigate the relationship between DII and MM. The case group participating in the study was on average 54 years old and mostly male (52.3%). After adjusting for age, sex, and energy intake, we found that individuals with the highest DII scores were significantly less likely to have MM compared to those with the lowest scores (OR: 0.02; 95% CI 0.01, 0.08). Additional adjustment with other confounders confirmed this association (OR: 0.03; 95% CI 0.01, 0.13). This association did not change significantly with further adjustment for BMI (OR: 0.04; 95% CI 0.01, 0.14). In conclusion, our research showed that a pro-inflammatory diet was associated with a significantly higher risk of MM. If our findings are confirmed in other large studies, these data will provide personalized approaches for MM patients, particularly for physicians and registered cancer dietitians. |
| format | Article |
| id | doaj-art-9aed8065f5b140cea0e85249b36124b1 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-9aed8065f5b140cea0e85249b36124b12025-01-26T12:29:50ZengNature PortfolioScientific Reports2045-23222025-01-011511910.1038/s41598-025-87494-7The association between the dietary inflammatory index and multiple myeloma: a case–control studyHoda Zahedi0Mohammad-Reza Jowshan1Hamid Rasekhi2Maryam Amini3Omid Sadeghi4Mahshid Mehdizadeh5Sayeh Parkhideh6Moloud Payab7Erfan Zamani8Mahdi Shadnoush9Abbas Hajifathali10Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical SciencesDepartment of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical SciencesDepartment of Nutrition Research, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical SciencesDepartment of Nutrition Research, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical SciencesNutrition and Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical SciencesHematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical SciencesHematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical SciencesNon-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical SciencesSchool of Medicine, Tehran University of Medical SciencesDepartment of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical SciencesHematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical SciencesAbstract The dietary inflammatory index (DII) is a common grading system for diet inflammatory potential. Recent investigations link DII to hematopoietic malignancies. However, the relationship between DII and Multiple myeloma (MM) is unknown. DII and MM were examined in a present case–control study of Iranian adults. This case–controlstudy was conducted on adults aged 20 to 75 years, selecting 149 cases with newly diagnosed multiple myeloma and 359 healthy individuals. Dietary assessment was conducted using a validated semi-quantitative food frequency questionnaire (FFQ) including 154 items, and energy-adjusted DII scores were calculated to determine the level of inflammatory properties in each individual’s diet using 29 dietary parameters. Conditional logistic regression models were used to investigate the relationship between DII and MM. The case group participating in the study was on average 54 years old and mostly male (52.3%). After adjusting for age, sex, and energy intake, we found that individuals with the highest DII scores were significantly less likely to have MM compared to those with the lowest scores (OR: 0.02; 95% CI 0.01, 0.08). Additional adjustment with other confounders confirmed this association (OR: 0.03; 95% CI 0.01, 0.13). This association did not change significantly with further adjustment for BMI (OR: 0.04; 95% CI 0.01, 0.14). In conclusion, our research showed that a pro-inflammatory diet was associated with a significantly higher risk of MM. If our findings are confirmed in other large studies, these data will provide personalized approaches for MM patients, particularly for physicians and registered cancer dietitians.https://doi.org/10.1038/s41598-025-87494-7Dietary inflammatory indexMultiple myelomacase–controlstudyLeukemia |
| spellingShingle | Hoda Zahedi Mohammad-Reza Jowshan Hamid Rasekhi Maryam Amini Omid Sadeghi Mahshid Mehdizadeh Sayeh Parkhideh Moloud Payab Erfan Zamani Mahdi Shadnoush Abbas Hajifathali The association between the dietary inflammatory index and multiple myeloma: a case–control study Scientific Reports Dietary inflammatory index Multiple myeloma case–controlstudy Leukemia |
| title | The association between the dietary inflammatory index and multiple myeloma: a case–control study |
| title_full | The association between the dietary inflammatory index and multiple myeloma: a case–control study |
| title_fullStr | The association between the dietary inflammatory index and multiple myeloma: a case–control study |
| title_full_unstemmed | The association between the dietary inflammatory index and multiple myeloma: a case–control study |
| title_short | The association between the dietary inflammatory index and multiple myeloma: a case–control study |
| title_sort | association between the dietary inflammatory index and multiple myeloma a case control study |
| topic | Dietary inflammatory index Multiple myeloma case–controlstudy Leukemia |
| url | https://doi.org/10.1038/s41598-025-87494-7 |
| work_keys_str_mv | AT hodazahedi theassociationbetweenthedietaryinflammatoryindexandmultiplemyelomaacasecontrolstudy AT mohammadrezajowshan theassociationbetweenthedietaryinflammatoryindexandmultiplemyelomaacasecontrolstudy AT hamidrasekhi theassociationbetweenthedietaryinflammatoryindexandmultiplemyelomaacasecontrolstudy AT maryamamini theassociationbetweenthedietaryinflammatoryindexandmultiplemyelomaacasecontrolstudy AT omidsadeghi theassociationbetweenthedietaryinflammatoryindexandmultiplemyelomaacasecontrolstudy AT mahshidmehdizadeh theassociationbetweenthedietaryinflammatoryindexandmultiplemyelomaacasecontrolstudy AT sayehparkhideh theassociationbetweenthedietaryinflammatoryindexandmultiplemyelomaacasecontrolstudy AT moloudpayab theassociationbetweenthedietaryinflammatoryindexandmultiplemyelomaacasecontrolstudy AT erfanzamani theassociationbetweenthedietaryinflammatoryindexandmultiplemyelomaacasecontrolstudy AT mahdishadnoush theassociationbetweenthedietaryinflammatoryindexandmultiplemyelomaacasecontrolstudy AT abbashajifathali theassociationbetweenthedietaryinflammatoryindexandmultiplemyelomaacasecontrolstudy AT hodazahedi associationbetweenthedietaryinflammatoryindexandmultiplemyelomaacasecontrolstudy AT mohammadrezajowshan associationbetweenthedietaryinflammatoryindexandmultiplemyelomaacasecontrolstudy AT hamidrasekhi associationbetweenthedietaryinflammatoryindexandmultiplemyelomaacasecontrolstudy AT maryamamini associationbetweenthedietaryinflammatoryindexandmultiplemyelomaacasecontrolstudy AT omidsadeghi associationbetweenthedietaryinflammatoryindexandmultiplemyelomaacasecontrolstudy AT mahshidmehdizadeh associationbetweenthedietaryinflammatoryindexandmultiplemyelomaacasecontrolstudy AT sayehparkhideh associationbetweenthedietaryinflammatoryindexandmultiplemyelomaacasecontrolstudy AT moloudpayab associationbetweenthedietaryinflammatoryindexandmultiplemyelomaacasecontrolstudy AT erfanzamani associationbetweenthedietaryinflammatoryindexandmultiplemyelomaacasecontrolstudy AT mahdishadnoush associationbetweenthedietaryinflammatoryindexandmultiplemyelomaacasecontrolstudy AT abbashajifathali associationbetweenthedietaryinflammatoryindexandmultiplemyelomaacasecontrolstudy |