OM-101 Decreases the Fibrotic Response Associated with Proliferative Vitreoretinopathy
Purpose. This study aimed to investigate the effect of OM-101 on the fibrotic response occurring in proliferative vitreoretinopathy (PVR) in an animal model. Methods. Antifibrotic effect of OM-101 was investigated in vivo. As control, eight weeks old c57black mice underwent intravitreal injection wi...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2017/1606854 |
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| _version_ | 1832559847147569152 |
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| author | Zeev Dvashi Keren Ben-Yaakov Tamir Weinberg Yoel Greenwald Ayala Pollack |
| author_facet | Zeev Dvashi Keren Ben-Yaakov Tamir Weinberg Yoel Greenwald Ayala Pollack |
| author_sort | Zeev Dvashi |
| collection | DOAJ |
| description | Purpose. This study aimed to investigate the effect of OM-101 on the fibrotic response occurring in proliferative vitreoretinopathy (PVR) in an animal model. Methods. Antifibrotic effect of OM-101 was investigated in vivo. As control, eight weeks old c57black mice underwent intravitreal injection with Hepes (group A) or dispase (0.3 units), to induce retinal detachment (RD) and PVR. The dispase-injected mice were randomly divided into two groups B and C (N=25 mice); in group C, the eyes were treated with intravitreal injection of OM-101 (3 μl), and group B with PBS, as a control. After additional five days, mice were injected with the same initial treatment. Three days later, mice were euthanized, and the eyes were enucleated and processed for histological analysis. Results. Intravitreal injection of dispase caused RD in 64% of the mice in group B, and 93% of those mice had PVR. Only 32% of mice treated with OM-101 and dispase (group C) developed RD, and only 25% of those developed PVR. Conclusions. OM-101 was found effective in reducing the incidence of RD and PVR maintaining the normal architecture of the retina. This study suggests that OM-101 is a potentially effective and safe drug for the treatment of PVR patients. |
| format | Article |
| id | doaj-art-9ae6b6fd48da4db99359cf7df736bf12 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-9ae6b6fd48da4db99359cf7df736bf122025-02-03T01:29:01ZengWileyJournal of Ophthalmology2090-004X2090-00582017-01-01201710.1155/2017/16068541606854OM-101 Decreases the Fibrotic Response Associated with Proliferative VitreoretinopathyZeev Dvashi0Keren Ben-Yaakov1Tamir Weinberg2Yoel Greenwald3Ayala Pollack4Kaplan Medical Center-Rehovot, Affiliated to Hadassah-Hebrew University of Jerusalem, Rehovot, IsraelKaplan Medical Center-Rehovot, Affiliated to Hadassah-Hebrew University of Jerusalem, Rehovot, IsraelKaplan Medical Center-Rehovot, Affiliated to Hadassah-Hebrew University of Jerusalem, Rehovot, IsraelKaplan Medical Center-Rehovot, Affiliated to Hadassah-Hebrew University of Jerusalem, Rehovot, IsraelKaplan Medical Center-Rehovot, Affiliated to Hadassah-Hebrew University of Jerusalem, Rehovot, IsraelPurpose. This study aimed to investigate the effect of OM-101 on the fibrotic response occurring in proliferative vitreoretinopathy (PVR) in an animal model. Methods. Antifibrotic effect of OM-101 was investigated in vivo. As control, eight weeks old c57black mice underwent intravitreal injection with Hepes (group A) or dispase (0.3 units), to induce retinal detachment (RD) and PVR. The dispase-injected mice were randomly divided into two groups B and C (N=25 mice); in group C, the eyes were treated with intravitreal injection of OM-101 (3 μl), and group B with PBS, as a control. After additional five days, mice were injected with the same initial treatment. Three days later, mice were euthanized, and the eyes were enucleated and processed for histological analysis. Results. Intravitreal injection of dispase caused RD in 64% of the mice in group B, and 93% of those mice had PVR. Only 32% of mice treated with OM-101 and dispase (group C) developed RD, and only 25% of those developed PVR. Conclusions. OM-101 was found effective in reducing the incidence of RD and PVR maintaining the normal architecture of the retina. This study suggests that OM-101 is a potentially effective and safe drug for the treatment of PVR patients.http://dx.doi.org/10.1155/2017/1606854 |
| spellingShingle | Zeev Dvashi Keren Ben-Yaakov Tamir Weinberg Yoel Greenwald Ayala Pollack OM-101 Decreases the Fibrotic Response Associated with Proliferative Vitreoretinopathy Journal of Ophthalmology |
| title | OM-101 Decreases the Fibrotic Response Associated with Proliferative Vitreoretinopathy |
| title_full | OM-101 Decreases the Fibrotic Response Associated with Proliferative Vitreoretinopathy |
| title_fullStr | OM-101 Decreases the Fibrotic Response Associated with Proliferative Vitreoretinopathy |
| title_full_unstemmed | OM-101 Decreases the Fibrotic Response Associated with Proliferative Vitreoretinopathy |
| title_short | OM-101 Decreases the Fibrotic Response Associated with Proliferative Vitreoretinopathy |
| title_sort | om 101 decreases the fibrotic response associated with proliferative vitreoretinopathy |
| url | http://dx.doi.org/10.1155/2017/1606854 |
| work_keys_str_mv | AT zeevdvashi om101decreasesthefibroticresponseassociatedwithproliferativevitreoretinopathy AT kerenbenyaakov om101decreasesthefibroticresponseassociatedwithproliferativevitreoretinopathy AT tamirweinberg om101decreasesthefibroticresponseassociatedwithproliferativevitreoretinopathy AT yoelgreenwald om101decreasesthefibroticresponseassociatedwithproliferativevitreoretinopathy AT ayalapollack om101decreasesthefibroticresponseassociatedwithproliferativevitreoretinopathy |