Molecular Mechanisms of Oxytocin Signaling at the Synaptic Connection
Aberrant regulation of oxytocin signaling is associated with the etiology of neurodevelopmental disorders. Synaptic dysfunctions in neurodevelopmental disorders are becoming increasingly known, and their pathogenic mechanisms could be a target of potential therapeutic intervention. Therefore, it is...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2018/4864107 |
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| author | Jan Bakos Annamaria Srancikova Tomas Havranek Zuzana Bacova |
| author_facet | Jan Bakos Annamaria Srancikova Tomas Havranek Zuzana Bacova |
| author_sort | Jan Bakos |
| collection | DOAJ |
| description | Aberrant regulation of oxytocin signaling is associated with the etiology of neurodevelopmental disorders. Synaptic dysfunctions in neurodevelopmental disorders are becoming increasingly known, and their pathogenic mechanisms could be a target of potential therapeutic intervention. Therefore, it is important to pay attention to the role of oxytocin and its receptor in synapse structure, function, and neuron connectivity. An early alteration in oxytocin signaling may disturb neuronal maturation and may have short-term and long-term pathological consequences. At the molecular level, neurodevelopmental disorders include alterations in cytoskeletal rearrangement and neuritogenesis resulting in a diversity of synaptopathies. The presence of oxytocin receptors in the presynaptic and postsynaptic membranes and the direct effects of oxytocin on neuronal excitability by regulating the activity of ion channels in the cell membrane implicate that alterations in oxytocin signaling could be involved in synaptopathies. The ability of oxytocin to modulate neurogenesis, synaptic plasticity, and certain parameters of cytoskeletal arrangement is discussed in the present review. |
| format | Article |
| id | doaj-art-9ade7956a6c843b5907a7fc0d1f8d8f7 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-9ade7956a6c843b5907a7fc0d1f8d8f72025-02-03T01:02:01ZengWileyNeural Plasticity2090-59041687-54432018-01-01201810.1155/2018/48641074864107Molecular Mechanisms of Oxytocin Signaling at the Synaptic ConnectionJan Bakos0Annamaria Srancikova1Tomas Havranek2Zuzana Bacova3Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, SlovakiaInstitute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, SlovakiaInstitute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, SlovakiaInstitute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, SlovakiaAberrant regulation of oxytocin signaling is associated with the etiology of neurodevelopmental disorders. Synaptic dysfunctions in neurodevelopmental disorders are becoming increasingly known, and their pathogenic mechanisms could be a target of potential therapeutic intervention. Therefore, it is important to pay attention to the role of oxytocin and its receptor in synapse structure, function, and neuron connectivity. An early alteration in oxytocin signaling may disturb neuronal maturation and may have short-term and long-term pathological consequences. At the molecular level, neurodevelopmental disorders include alterations in cytoskeletal rearrangement and neuritogenesis resulting in a diversity of synaptopathies. The presence of oxytocin receptors in the presynaptic and postsynaptic membranes and the direct effects of oxytocin on neuronal excitability by regulating the activity of ion channels in the cell membrane implicate that alterations in oxytocin signaling could be involved in synaptopathies. The ability of oxytocin to modulate neurogenesis, synaptic plasticity, and certain parameters of cytoskeletal arrangement is discussed in the present review.http://dx.doi.org/10.1155/2018/4864107 |
| spellingShingle | Jan Bakos Annamaria Srancikova Tomas Havranek Zuzana Bacova Molecular Mechanisms of Oxytocin Signaling at the Synaptic Connection Neural Plasticity |
| title | Molecular Mechanisms of Oxytocin Signaling at the Synaptic Connection |
| title_full | Molecular Mechanisms of Oxytocin Signaling at the Synaptic Connection |
| title_fullStr | Molecular Mechanisms of Oxytocin Signaling at the Synaptic Connection |
| title_full_unstemmed | Molecular Mechanisms of Oxytocin Signaling at the Synaptic Connection |
| title_short | Molecular Mechanisms of Oxytocin Signaling at the Synaptic Connection |
| title_sort | molecular mechanisms of oxytocin signaling at the synaptic connection |
| url | http://dx.doi.org/10.1155/2018/4864107 |
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