Biomarkers to Improve Diagnosis and Monitoring of Obstructive Sleep Apnea Syndrome: Current Status and Future Perspectives
Obstructive sleep apnea syndrome (OSAS) is characterized by recurrent episodes of upper airway collapse associated with oxygen desaturation and sleep disruption. It is proposed that these periodic changes lead to molecular variations that can be detected by assessing serum biomarkers. Studies have i...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Pulmonary Medicine |
| Online Access: | http://dx.doi.org/10.1155/2014/930535 |
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| author | Konstantinos Archontogeorgis Evangelia Nena Nikolaos Papanas Paschalis Steiropoulos |
| author_facet | Konstantinos Archontogeorgis Evangelia Nena Nikolaos Papanas Paschalis Steiropoulos |
| author_sort | Konstantinos Archontogeorgis |
| collection | DOAJ |
| description | Obstructive sleep apnea syndrome (OSAS) is characterized by recurrent episodes of upper airway collapse associated with oxygen desaturation and sleep disruption. It is proposed that these periodic changes lead to molecular variations that can be detected by assessing serum biomarkers. Studies have identified inflammatory, oxidative, and metabolic perturbations attributable to sleep-disordered breathing. Given that OSAS is associated with increased cardiovascular and cerebrovascular morbidity, the ideal biomarker should enable timely recognition with the possibility of intervention. There is accumulating data on the utility of serum biomarkers for the evaluation of disease severity, prognosis, and response to treatment. However, current knowledge is limited by data collection techniques, disease complexity, and potential confounding factors. The current paper reviews the literature on the use of serum biomarkers in OSAS. It is concluded that the ideal serum biomarker still needs to be discovered, while caution is needed in the interpretation of hitherto available results. |
| format | Article |
| id | doaj-art-9ac564acd3fd4fda98ba4ee68426ef0b |
| institution | Kabale University |
| issn | 2090-1836 2090-1844 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Medicine |
| spelling | doaj-art-9ac564acd3fd4fda98ba4ee68426ef0b2025-02-03T01:21:24ZengWileyPulmonary Medicine2090-18362090-18442014-01-01201410.1155/2014/930535930535Biomarkers to Improve Diagnosis and Monitoring of Obstructive Sleep Apnea Syndrome: Current Status and Future PerspectivesKonstantinos Archontogeorgis0Evangelia Nena1Nikolaos Papanas2Paschalis Steiropoulos3Department of Pneumonology, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, GreeceLaboratory of Hygiene and Environmental Protection, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, GreeceSecond Department of Internal Medicine, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, GreeceDepartment of Pneumonology, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, GreeceObstructive sleep apnea syndrome (OSAS) is characterized by recurrent episodes of upper airway collapse associated with oxygen desaturation and sleep disruption. It is proposed that these periodic changes lead to molecular variations that can be detected by assessing serum biomarkers. Studies have identified inflammatory, oxidative, and metabolic perturbations attributable to sleep-disordered breathing. Given that OSAS is associated with increased cardiovascular and cerebrovascular morbidity, the ideal biomarker should enable timely recognition with the possibility of intervention. There is accumulating data on the utility of serum biomarkers for the evaluation of disease severity, prognosis, and response to treatment. However, current knowledge is limited by data collection techniques, disease complexity, and potential confounding factors. The current paper reviews the literature on the use of serum biomarkers in OSAS. It is concluded that the ideal serum biomarker still needs to be discovered, while caution is needed in the interpretation of hitherto available results.http://dx.doi.org/10.1155/2014/930535 |
| spellingShingle | Konstantinos Archontogeorgis Evangelia Nena Nikolaos Papanas Paschalis Steiropoulos Biomarkers to Improve Diagnosis and Monitoring of Obstructive Sleep Apnea Syndrome: Current Status and Future Perspectives Pulmonary Medicine |
| title | Biomarkers to Improve Diagnosis and Monitoring of Obstructive Sleep Apnea Syndrome: Current Status and Future Perspectives |
| title_full | Biomarkers to Improve Diagnosis and Monitoring of Obstructive Sleep Apnea Syndrome: Current Status and Future Perspectives |
| title_fullStr | Biomarkers to Improve Diagnosis and Monitoring of Obstructive Sleep Apnea Syndrome: Current Status and Future Perspectives |
| title_full_unstemmed | Biomarkers to Improve Diagnosis and Monitoring of Obstructive Sleep Apnea Syndrome: Current Status and Future Perspectives |
| title_short | Biomarkers to Improve Diagnosis and Monitoring of Obstructive Sleep Apnea Syndrome: Current Status and Future Perspectives |
| title_sort | biomarkers to improve diagnosis and monitoring of obstructive sleep apnea syndrome current status and future perspectives |
| url | http://dx.doi.org/10.1155/2014/930535 |
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