Novel co-culture model of T cells and midbrain organoids for investigating neurodegeneration in Parkinson’s disease
Abstract Recent studies demonstrate that brain infiltration of peripheral immune cells and their interaction with brain-resident cells contribute to Parkinson’s disease (PD). However, mechanisms of T cell-brain cell communication are not fully elucidated and models allowing investigation of interact...
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| Main Authors: | Elizaveta Gerasimova, Amke C. Beenen, Daniil Kachkin, Martin Regensburger, Sebastian Zundler, David B. Blumenthal, Gloria Lutzny-Geier, Beate Winner, Iryna Prots |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-02-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-025-00882-8 |
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