Novel co-culture model of T cells and midbrain organoids for investigating neurodegeneration in Parkinson’s disease

Abstract Recent studies demonstrate that brain infiltration of peripheral immune cells and their interaction with brain-resident cells contribute to Parkinson’s disease (PD). However, mechanisms of T cell-brain cell communication are not fully elucidated and models allowing investigation of interact...

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Bibliographic Details
Main Authors: Elizaveta Gerasimova, Amke C. Beenen, Daniil Kachkin, Martin Regensburger, Sebastian Zundler, David B. Blumenthal, Gloria Lutzny-Geier, Beate Winner, Iryna Prots
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-025-00882-8
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