Studies on the biological effects of ozone: 8. Effects on the total antioxidant status and on interleukin-8 production
Ozone (O3) is a controversial gas because, owing to its potent oxidant properties, it exerts damaging effects on the respiratory tract and yet it has been used for four decades as a therapy. While the disinfectant activity of O3 is understandable, it is less clear how other biological effects can be...
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| Format: | Article |
| Language: | English |
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Wiley
1998-01-01
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| Series: | Mediators of Inflammation |
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| Online Access: | http://dx.doi.org/10.1080/09629359890820 |
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| author | V. Bocci G. Valacchi F. Corradeschi G. Fanetti |
| author_facet | V. Bocci G. Valacchi F. Corradeschi G. Fanetti |
| author_sort | V. Bocci |
| collection | DOAJ |
| description | Ozone (O3) is a controversial gas because, owing to its potent oxidant properties, it exerts damaging effects on the respiratory tract and yet it has been used for four decades as a therapy. While the disinfectant activity of O3 is understandable, it is less clear how other biological effects can be elicited in human blood with practically no toxicity. On the other hand plasma and cells are endowed with a powerful antioxidant system so that a fairly wide range of O3 concentrations between 40 and 80μ g/ml per gram of blood (˜0.83-1.66 mM) are effective but not deleterious. After blood ozonation total antioxidant status (TAS) and plasma protein thiol groups (PTG) decrease by 20% and 25%, respectively, while thiobarbituric acid reactive substances (TBARS) increases up to fivefold. The increase of haemolysis is negligible suggesting that the erythrocyte membrane is spared at the expense of other sacrificial substrates. While there is a clear relationship between the ozone dose and IL-8 levels, we have noticed that high TAS and PTG values inhibit the cytokine production. This is in line with the current idea that hydrogen peroxide, as a byproduct of O3 decomposition, acts as a messenger for the cytokine induction. |
| format | Article |
| id | doaj-art-9ab3fc1fad5a4b528c33239bc31bb34c |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1998-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-9ab3fc1fad5a4b528c33239bc31bb34c2025-02-03T05:49:56ZengWileyMediators of Inflammation0962-93511466-18611998-01-017531331710.1080/09629359890820Studies on the biological effects of ozone: 8. Effects on the total antioxidant status and on interleukin-8 productionV. Bocci0G. Valacchi1F. Corradeschi2G. Fanetti3Institute of General Physiology, University of Siena, Via Laterina 8, Siena 53100, ItalyInstitute of General Physiology, University of Siena, Via Laterina 8, Siena 53100, ItalyInstitute of General Physiology, University of Siena, Via Laterina 8, Siena 53100, ItalyBlood Bank–Azienda Ospedaliera Senese, Siena 53100, ItalyOzone (O3) is a controversial gas because, owing to its potent oxidant properties, it exerts damaging effects on the respiratory tract and yet it has been used for four decades as a therapy. While the disinfectant activity of O3 is understandable, it is less clear how other biological effects can be elicited in human blood with practically no toxicity. On the other hand plasma and cells are endowed with a powerful antioxidant system so that a fairly wide range of O3 concentrations between 40 and 80μ g/ml per gram of blood (˜0.83-1.66 mM) are effective but not deleterious. After blood ozonation total antioxidant status (TAS) and plasma protein thiol groups (PTG) decrease by 20% and 25%, respectively, while thiobarbituric acid reactive substances (TBARS) increases up to fivefold. The increase of haemolysis is negligible suggesting that the erythrocyte membrane is spared at the expense of other sacrificial substrates. While there is a clear relationship between the ozone dose and IL-8 levels, we have noticed that high TAS and PTG values inhibit the cytokine production. This is in line with the current idea that hydrogen peroxide, as a byproduct of O3 decomposition, acts as a messenger for the cytokine induction.http://dx.doi.org/10.1080/09629359890820OzonePlasma oxidationAntioxidantsProtein thiol groupsInterleukin-8. |
| spellingShingle | V. Bocci G. Valacchi F. Corradeschi G. Fanetti Studies on the biological effects of ozone: 8. Effects on the total antioxidant status and on interleukin-8 production Mediators of Inflammation Ozone Plasma oxidation Antioxidants Protein thiol groups Interleukin-8. |
| title | Studies on the biological effects of ozone: 8. Effects on the total antioxidant status and on interleukin-8 production |
| title_full | Studies on the biological effects of ozone: 8. Effects on the total antioxidant status and on interleukin-8 production |
| title_fullStr | Studies on the biological effects of ozone: 8. Effects on the total antioxidant status and on interleukin-8 production |
| title_full_unstemmed | Studies on the biological effects of ozone: 8. Effects on the total antioxidant status and on interleukin-8 production |
| title_short | Studies on the biological effects of ozone: 8. Effects on the total antioxidant status and on interleukin-8 production |
| title_sort | studies on the biological effects of ozone 8 effects on the total antioxidant status and on interleukin 8 production |
| topic | Ozone Plasma oxidation Antioxidants Protein thiol groups Interleukin-8. |
| url | http://dx.doi.org/10.1080/09629359890820 |
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