Hepatitis B and C infection in tuberculosis patients in the Hauts Bassins region of Burkina Faso, West Africa
Tuberculosis (TB) and viral hepatitis B and C represent significant public health concerns. Co-infection with TB and hepatitis B and/or C results in significant complications, including suboptimal treatment outcomes in TB and the development of hepatitis induced by anti-TB drugs. At present, no data...
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Elsevier
2025-06-01
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| Series: | Journal of Clinical Virology Plus |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667038025000109 |
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| author | Armel Moumouni Sanou Abdoulaye Dera Jeoffray Diendere Nina Mathuola Geneviève Ouattara Eric Kyelem Arhouna Siguina Traore Arouna Dao Arielle Sandra Bettina Badiel Ina Marie Angèle Traore Michel Kiréopori.B Gomgnimbou Isidore Bonkoungou Gautier Henri Ouedraogo |
| author_facet | Armel Moumouni Sanou Abdoulaye Dera Jeoffray Diendere Nina Mathuola Geneviève Ouattara Eric Kyelem Arhouna Siguina Traore Arouna Dao Arielle Sandra Bettina Badiel Ina Marie Angèle Traore Michel Kiréopori.B Gomgnimbou Isidore Bonkoungou Gautier Henri Ouedraogo |
| author_sort | Armel Moumouni Sanou |
| collection | DOAJ |
| description | Tuberculosis (TB) and viral hepatitis B and C represent significant public health concerns. Co-infection with TB and hepatitis B and/or C results in significant complications, including suboptimal treatment outcomes in TB and the development of hepatitis induced by anti-TB drugs. At present, no data on these co-infections are available for Burkina Faso. This study investigates the epidemiology of these co-infections in TB patients in the Hauts-Bassins region of Burkina Faso. A cross-sectional analytical study was conducted in health facilities involved in the management of TB in the Hauts-Bassins region of Burkina Faso from October 2023 to June 2024. For each consenting TB patient, data were collected. A blood sample was obtained and analyzed for a range of infection markers (HBsAg, HBV DNA, anti-HCV antibodies, and HCV RNA) and liver enzymes (ALT and γ-GT). A total of 259 TB patients were included in the study. The mean age of the participants was 39.7 ± 15.9 years. The overall prevalence of HBsAg was 10.03 % and 3.8 % for anti-HCV. Among the HBsAg-positive samples, HBV DNA was detected in all cases, with 68.2 % exhibiting a viral load exceeding 20,000 IU/mL. Elevated ALT was observed in 19.2 % of TB/HBsAg patients and in 30.0 % of TB/anti-HCV. About γ-GT, an elavated result was observed in 46.1 % of TB/HBsAg patients and 40.0 % of TB/anti-HCV patients. The results demonstrated a high prevalence of hepatitis B and intermediate exposure to HCV in TB patients. It is thus recommended that routine screening for these diseases be considered in TB patients. |
| format | Article |
| id | doaj-art-9ab0d3bc3c4e4d0d93b7455a0a322293 |
| institution | OA Journals |
| issn | 2667-0380 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Clinical Virology Plus |
| spelling | doaj-art-9ab0d3bc3c4e4d0d93b7455a0a3222932025-08-20T02:33:12ZengElsevierJournal of Clinical Virology Plus2667-03802025-06-015210021110.1016/j.jcvp.2025.100211Hepatitis B and C infection in tuberculosis patients in the Hauts Bassins region of Burkina Faso, West AfricaArmel Moumouni Sanou0Abdoulaye Dera1Jeoffray Diendere2Nina Mathuola Geneviève Ouattara3Eric Kyelem4Arhouna Siguina Traore5Arouna Dao6Arielle Sandra Bettina Badiel7Ina Marie Angèle Traore8Michel Kiréopori.B Gomgnimbou9Isidore Bonkoungou10Gautier Henri Ouedraogo11Laboratoire de Recherche sur les Maladies Infectieuses et Parasitaires (LR-MIP), Institut de Recherche en Sciences de la Santé (IRSS), 01 BP 545 Bobo-Dioulasso, Burkina Faso; Corresponding author.Laboratoire de Recherche sur les Maladies Infectieuses et Parasitaires (LR-MIP), Institut de Recherche en Sciences de la Santé (IRSS), 01 BP 545 Bobo-Dioulasso, Burkina FasoLa Laboratoire de Recherche en Santé Publique et Nutrition (LR-SPN), Institut de Recherche en Sciences de la Santé (IRSS), 01 BP 545 Bobo-Dioulasso, Burkina FasoLaboratoire de Recherche sur les Maladies Infectieuses et Parasitaires (LR-MIP), Institut de Recherche en Sciences de la Santé (IRSS), 01 BP 545 Bobo-Dioulasso, Burkina FasoLaboratoire de Recherche sur les Maladies Infectieuses et Parasitaires (LR-MIP), Institut de Recherche en Sciences de la Santé (IRSS), 01 BP 545 Bobo-Dioulasso, Burkina FasoLaboratoire de Recherche sur les Maladies Infectieuses et Parasitaires (LR-MIP), Institut de Recherche en Sciences de la Santé (IRSS), 01 BP 545 Bobo-Dioulasso, Burkina FasoLaboratoire de Recherche sur les Maladies Infectieuses et Parasitaires (LR-MIP), Institut de Recherche en Sciences de la Santé (IRSS), 01 BP 545 Bobo-Dioulasso, Burkina FasoLaboratoire de Recherche sur les Maladies Infectieuses et Parasitaires (LR-MIP), Institut de Recherche en Sciences de la Santé (IRSS), 01 BP 545 Bobo-Dioulasso, Burkina FasoLaboratoire de Recherche sur les Maladies Infectieuses et Parasitaires (LR-MIP), Institut de Recherche en Sciences de la Santé (IRSS), 01 BP 545 Bobo-Dioulasso, Burkina FasoInstitut Supérieur des Sciences de la Santé (INSSA), Université́ Nazi Boni, Bobo-Dioulasso 1091, Burkina Faso; Équipe Biologie Moléculaire et Biotechnologies, Laboratoire de Recherche, Centre MURAZ, Bobo-Dioulasso, Burkina FasoLaboratory of Molecular Biology, Epidemiology and Monitoring of Bacteria and Viruses Transmitted by Food (LaBESTA), University Joseph KI-ZERBO, 03 BP 7021, Ouagadougou 03, Burkina FasoLaboratoire de Recherche sur les Maladies Infectieuses et Parasitaires (LR-MIP), Institut de Recherche en Sciences de la Santé (IRSS), 03 BP 7192 Ouagadougou, Burkina FasoTuberculosis (TB) and viral hepatitis B and C represent significant public health concerns. Co-infection with TB and hepatitis B and/or C results in significant complications, including suboptimal treatment outcomes in TB and the development of hepatitis induced by anti-TB drugs. At present, no data on these co-infections are available for Burkina Faso. This study investigates the epidemiology of these co-infections in TB patients in the Hauts-Bassins region of Burkina Faso. A cross-sectional analytical study was conducted in health facilities involved in the management of TB in the Hauts-Bassins region of Burkina Faso from October 2023 to June 2024. For each consenting TB patient, data were collected. A blood sample was obtained and analyzed for a range of infection markers (HBsAg, HBV DNA, anti-HCV antibodies, and HCV RNA) and liver enzymes (ALT and γ-GT). A total of 259 TB patients were included in the study. The mean age of the participants was 39.7 ± 15.9 years. The overall prevalence of HBsAg was 10.03 % and 3.8 % for anti-HCV. Among the HBsAg-positive samples, HBV DNA was detected in all cases, with 68.2 % exhibiting a viral load exceeding 20,000 IU/mL. Elevated ALT was observed in 19.2 % of TB/HBsAg patients and in 30.0 % of TB/anti-HCV. About γ-GT, an elavated result was observed in 46.1 % of TB/HBsAg patients and 40.0 % of TB/anti-HCV patients. The results demonstrated a high prevalence of hepatitis B and intermediate exposure to HCV in TB patients. It is thus recommended that routine screening for these diseases be considered in TB patients.http://www.sciencedirect.com/science/article/pii/S2667038025000109TuberculosisHepatitis BHepatitis CCoinfectionBurkina Faso |
| spellingShingle | Armel Moumouni Sanou Abdoulaye Dera Jeoffray Diendere Nina Mathuola Geneviève Ouattara Eric Kyelem Arhouna Siguina Traore Arouna Dao Arielle Sandra Bettina Badiel Ina Marie Angèle Traore Michel Kiréopori.B Gomgnimbou Isidore Bonkoungou Gautier Henri Ouedraogo Hepatitis B and C infection in tuberculosis patients in the Hauts Bassins region of Burkina Faso, West Africa Journal of Clinical Virology Plus Tuberculosis Hepatitis B Hepatitis C Coinfection Burkina Faso |
| title | Hepatitis B and C infection in tuberculosis patients in the Hauts Bassins region of Burkina Faso, West Africa |
| title_full | Hepatitis B and C infection in tuberculosis patients in the Hauts Bassins region of Burkina Faso, West Africa |
| title_fullStr | Hepatitis B and C infection in tuberculosis patients in the Hauts Bassins region of Burkina Faso, West Africa |
| title_full_unstemmed | Hepatitis B and C infection in tuberculosis patients in the Hauts Bassins region of Burkina Faso, West Africa |
| title_short | Hepatitis B and C infection in tuberculosis patients in the Hauts Bassins region of Burkina Faso, West Africa |
| title_sort | hepatitis b and c infection in tuberculosis patients in the hauts bassins region of burkina faso west africa |
| topic | Tuberculosis Hepatitis B Hepatitis C Coinfection Burkina Faso |
| url | http://www.sciencedirect.com/science/article/pii/S2667038025000109 |
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