Association of Insulin Resistance with Glucose and Lipid Metabolism: Ethnic Heterogeneity in Far Western China
Objective. To study the relationships between IR and glucose and lipid metabolism in far western China and these relationships’ ethnic heterogeneity. Methods. From the baseline survey, 419 Uygur cases, 331 Kazak cases, and 220 Han cases were randomly selected, resulting in a total of 970 cases for s...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/3825037 |
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| author | Yi-Zhong Yan Ru-Lin Ma Jing-Yu Zhang Jia He Jiao-Long Ma Hong-Rui Pang La-Ti Mu Yu-Song Ding Heng Guo Mei Zhang Jia-Ming Liu Dong-Sheng Rui Kui Wang Shu-Xia Guo |
| author_facet | Yi-Zhong Yan Ru-Lin Ma Jing-Yu Zhang Jia He Jiao-Long Ma Hong-Rui Pang La-Ti Mu Yu-Song Ding Heng Guo Mei Zhang Jia-Ming Liu Dong-Sheng Rui Kui Wang Shu-Xia Guo |
| author_sort | Yi-Zhong Yan |
| collection | DOAJ |
| description | Objective. To study the relationships between IR and glucose and lipid metabolism in far western China and these relationships’ ethnic heterogeneity. Methods. From the baseline survey, 419 Uygur cases, 331 Kazak cases, and 220 Han cases were randomly selected, resulting in a total of 970 cases for study. FINS concentration was measured by radioimmunoassay. Results. (1) In the Kazak population, IR was correlated with hyperglycemia; high levels of TC, TG, and LDL-C; and low levels of HDL-C and abdominal obesity (all P<0.05). (2) In the Uygur population, the influence of IR on hyperglycemia and abdominal obesity was the greatest. In the Kazak population, IR was associated with hyperglycemia most closely. In the Han population, IR may have had an impact on the incidence of low HDL-C levels. (3) After adjusting for sex, age, smoking status, and alcohol consumption, IR was still associated with anomalies in the metabolism of the Uygur, Kazak, and Han populations. Conclusion. IR was involved in the process of glucose and lipid metabolism, and its degree of involvement differed among the ethnicities studied. We could consider reducing the occurrence of abnormal glucose and lipid metabolism by controlling IR and aiming to reduce the prevalence of metabolic syndrome and related diseases. |
| format | Article |
| id | doaj-art-9aad11242d63449e8a836ba5254dfdb1 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-9aad11242d63449e8a836ba5254dfdb12025-02-03T01:02:46ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/38250373825037Association of Insulin Resistance with Glucose and Lipid Metabolism: Ethnic Heterogeneity in Far Western ChinaYi-Zhong Yan0Ru-Lin Ma1Jing-Yu Zhang2Jia He3Jiao-Long Ma4Hong-Rui Pang5La-Ti Mu6Yu-Song Ding7Heng Guo8Mei Zhang9Jia-Ming Liu10Dong-Sheng Rui11Kui Wang12Shu-Xia Guo13Department of Preventive Medicine, University of Shihezi, Shihezi 832000, ChinaDepartment of Preventive Medicine, University of Shihezi, Shihezi 832000, ChinaDepartment of Preventive Medicine, University of Shihezi, Shihezi 832000, ChinaDepartment of Preventive Medicine, University of Shihezi, Shihezi 832000, ChinaDepartment of Preventive Medicine, University of Shihezi, Shihezi 832000, ChinaDepartment of Preventive Medicine, University of Shihezi, Shihezi 832000, ChinaDepartment of Preventive Medicine, University of Shihezi, Shihezi 832000, ChinaDepartment of Preventive Medicine, University of Shihezi, Shihezi 832000, ChinaDepartment of Preventive Medicine, University of Shihezi, Shihezi 832000, ChinaDepartment of Preventive Medicine, University of Shihezi, Shihezi 832000, ChinaDepartment of Preventive Medicine, University of Shihezi, Shihezi 832000, ChinaDepartment of Preventive Medicine, University of Shihezi, Shihezi 832000, ChinaDepartment of Preventive Medicine, University of Shihezi, Shihezi 832000, ChinaDepartment of Preventive Medicine, University of Shihezi, Shihezi 832000, ChinaObjective. To study the relationships between IR and glucose and lipid metabolism in far western China and these relationships’ ethnic heterogeneity. Methods. From the baseline survey, 419 Uygur cases, 331 Kazak cases, and 220 Han cases were randomly selected, resulting in a total of 970 cases for study. FINS concentration was measured by radioimmunoassay. Results. (1) In the Kazak population, IR was correlated with hyperglycemia; high levels of TC, TG, and LDL-C; and low levels of HDL-C and abdominal obesity (all P<0.05). (2) In the Uygur population, the influence of IR on hyperglycemia and abdominal obesity was the greatest. In the Kazak population, IR was associated with hyperglycemia most closely. In the Han population, IR may have had an impact on the incidence of low HDL-C levels. (3) After adjusting for sex, age, smoking status, and alcohol consumption, IR was still associated with anomalies in the metabolism of the Uygur, Kazak, and Han populations. Conclusion. IR was involved in the process of glucose and lipid metabolism, and its degree of involvement differed among the ethnicities studied. We could consider reducing the occurrence of abnormal glucose and lipid metabolism by controlling IR and aiming to reduce the prevalence of metabolic syndrome and related diseases.http://dx.doi.org/10.1155/2016/3825037 |
| spellingShingle | Yi-Zhong Yan Ru-Lin Ma Jing-Yu Zhang Jia He Jiao-Long Ma Hong-Rui Pang La-Ti Mu Yu-Song Ding Heng Guo Mei Zhang Jia-Ming Liu Dong-Sheng Rui Kui Wang Shu-Xia Guo Association of Insulin Resistance with Glucose and Lipid Metabolism: Ethnic Heterogeneity in Far Western China Mediators of Inflammation |
| title | Association of Insulin Resistance with Glucose and Lipid Metabolism: Ethnic Heterogeneity in Far Western China |
| title_full | Association of Insulin Resistance with Glucose and Lipid Metabolism: Ethnic Heterogeneity in Far Western China |
| title_fullStr | Association of Insulin Resistance with Glucose and Lipid Metabolism: Ethnic Heterogeneity in Far Western China |
| title_full_unstemmed | Association of Insulin Resistance with Glucose and Lipid Metabolism: Ethnic Heterogeneity in Far Western China |
| title_short | Association of Insulin Resistance with Glucose and Lipid Metabolism: Ethnic Heterogeneity in Far Western China |
| title_sort | association of insulin resistance with glucose and lipid metabolism ethnic heterogeneity in far western china |
| url | http://dx.doi.org/10.1155/2016/3825037 |
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