Burden of coeliac disease in Germany: real-world insights from a large retrospective health insurance claims database analysis
Background: Coeliac disease (CeD) is a chronic immune-mediated disease triggered by exposure to dietary gluten in genetically predisposed individuals. The burden of CeD on patients and the healthcare system remains poorly evaluated in Germany. Objectives: To assess the healthcare resource utilisatio...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-02-01
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| Series: | Therapeutic Advances in Gastroenterology |
| Online Access: | https://doi.org/10.1177/17562848251314803 |
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| author | Bernd Bokemeyer Leonarda Serdani-Neuhaus Juliane Sünwoldt Christina Dünweber Svitlana Schnaidt Detlef Schuppan |
| author_facet | Bernd Bokemeyer Leonarda Serdani-Neuhaus Juliane Sünwoldt Christina Dünweber Svitlana Schnaidt Detlef Schuppan |
| author_sort | Bernd Bokemeyer |
| collection | DOAJ |
| description | Background: Coeliac disease (CeD) is a chronic immune-mediated disease triggered by exposure to dietary gluten in genetically predisposed individuals. The burden of CeD on patients and the healthcare system remains poorly evaluated in Germany. Objectives: To assess the healthcare resource utilisation (HCRU) and costs of diagnosed CeD patients in a German claims database. Design: A retrospective CeD case–control study was conducted using German claims data between 2017 and 2021. Methods: CeD diagnosis was defined by at least one inpatient or two outpatient diagnostic codes (International Statistical Classification of Diseases and Related Health Problems, 10th Revision, German Modification (ICD-10-GM) K90.0) within four quarters (irrespective of calendar year) for CeD during the study period. Controls (non-CeD patients) were matched in a ratio of 5:1 by age, Charlson Comorbidity Index, sex and region. HCRU (hospitalisations, outpatient visits, medication use, sick leaves) and healthcare costs (outpatient services, inpatient services, outpatient pharmaceuticals, sick leaves and aids and remedies) were compared between CeD patients and controls. Results: From the 3,352,188 patients with continuous enrolment during the study period (2017–2021), 8258 (0.25%) patients were identified as having a CeD diagnosis. The mean number of hospitalisations and outpatient visits within 5 years was 1.8- and 1.5-fold higher among matched CeD patients ( n = 8243) compared to their controls ( n = 41,215), resulting in an excess healthcare cost of €5251. Inpatient expenses were the main cost driver and accounted for 31.5% of total incremental costs. Conclusion: The current study showed that CeD patients have considerably higher HCRU and related costs compared to matched controls. Our findings suggest the need for improved treatment options for CeD patients in addition to a gluten-free diet. |
| format | Article |
| id | doaj-art-9aacfe23140e41b38ad1badcdc76ad88 |
| institution | Kabale University |
| issn | 1756-2848 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Gastroenterology |
| spelling | doaj-art-9aacfe23140e41b38ad1badcdc76ad882025-02-04T11:03:43ZengSAGE PublishingTherapeutic Advances in Gastroenterology1756-28482025-02-011810.1177/17562848251314803Burden of coeliac disease in Germany: real-world insights from a large retrospective health insurance claims database analysisBernd BokemeyerLeonarda Serdani-NeuhausJuliane SünwoldtChristina DünweberSvitlana SchnaidtDetlef SchuppanBackground: Coeliac disease (CeD) is a chronic immune-mediated disease triggered by exposure to dietary gluten in genetically predisposed individuals. The burden of CeD on patients and the healthcare system remains poorly evaluated in Germany. Objectives: To assess the healthcare resource utilisation (HCRU) and costs of diagnosed CeD patients in a German claims database. Design: A retrospective CeD case–control study was conducted using German claims data between 2017 and 2021. Methods: CeD diagnosis was defined by at least one inpatient or two outpatient diagnostic codes (International Statistical Classification of Diseases and Related Health Problems, 10th Revision, German Modification (ICD-10-GM) K90.0) within four quarters (irrespective of calendar year) for CeD during the study period. Controls (non-CeD patients) were matched in a ratio of 5:1 by age, Charlson Comorbidity Index, sex and region. HCRU (hospitalisations, outpatient visits, medication use, sick leaves) and healthcare costs (outpatient services, inpatient services, outpatient pharmaceuticals, sick leaves and aids and remedies) were compared between CeD patients and controls. Results: From the 3,352,188 patients with continuous enrolment during the study period (2017–2021), 8258 (0.25%) patients were identified as having a CeD diagnosis. The mean number of hospitalisations and outpatient visits within 5 years was 1.8- and 1.5-fold higher among matched CeD patients ( n = 8243) compared to their controls ( n = 41,215), resulting in an excess healthcare cost of €5251. Inpatient expenses were the main cost driver and accounted for 31.5% of total incremental costs. Conclusion: The current study showed that CeD patients have considerably higher HCRU and related costs compared to matched controls. Our findings suggest the need for improved treatment options for CeD patients in addition to a gluten-free diet.https://doi.org/10.1177/17562848251314803 |
| spellingShingle | Bernd Bokemeyer Leonarda Serdani-Neuhaus Juliane Sünwoldt Christina Dünweber Svitlana Schnaidt Detlef Schuppan Burden of coeliac disease in Germany: real-world insights from a large retrospective health insurance claims database analysis Therapeutic Advances in Gastroenterology |
| title | Burden of coeliac disease in Germany: real-world insights from a large retrospective health insurance claims database analysis |
| title_full | Burden of coeliac disease in Germany: real-world insights from a large retrospective health insurance claims database analysis |
| title_fullStr | Burden of coeliac disease in Germany: real-world insights from a large retrospective health insurance claims database analysis |
| title_full_unstemmed | Burden of coeliac disease in Germany: real-world insights from a large retrospective health insurance claims database analysis |
| title_short | Burden of coeliac disease in Germany: real-world insights from a large retrospective health insurance claims database analysis |
| title_sort | burden of coeliac disease in germany real world insights from a large retrospective health insurance claims database analysis |
| url | https://doi.org/10.1177/17562848251314803 |
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