Magnetic Resonance Image-Guided Biopsies with a High Detection Rate of Prostate Cancer
Aim. To explore the potential of transrectal magnetic resonance image- (MRI-) guided biopsies of the prostate in a patient cohort with prior negative ultrasound guided biopsies. Patients and Methods. Ninety-six men with suspected prostate cancer underwent MRI-guided prostate biopsies under real-time...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/975971 |
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| author | Dirk G. Engehausen Karl Engelhard Siegfried A. Schwab Michael Uder Sven Wach Bernd Wullich F. Steffen Krause |
| author_facet | Dirk G. Engehausen Karl Engelhard Siegfried A. Schwab Michael Uder Sven Wach Bernd Wullich F. Steffen Krause |
| author_sort | Dirk G. Engehausen |
| collection | DOAJ |
| description | Aim. To explore the potential of transrectal magnetic resonance image- (MRI-) guided biopsies of the prostate in a patient cohort with prior negative ultrasound guided biopsies. Patients and Methods. Ninety-six men with suspected prostate cancer underwent MRI-guided prostate biopsies under real-time imaging control in supine position.
Results. Adenocarcinoma of the prostate was detected in 39 of 96 patients. For individual core biopsies, MRI yielded a sensitivity of 93.0% and a specificity of 94.4%. When stratifying patients according to the free-to-total prostate-specific antigen (PSA) ratio, the prostate cancer discovery rate was significantly higher in the group with ratios less than 0.15 (57.1%). Conclusion. MRI-guided biopsy of the prostate is a diagnostic option for patients with suspected prostate cancer and a history of repeatedly negative transrectal ultrasound-guided biopsies. Combined with the free-to-total PSA ratio, it is a highly effective method for detecting prostate cancer. |
| format | Article |
| id | doaj-art-9aa76ddcdfad459f8eb0b517eda456b8 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-9aa76ddcdfad459f8eb0b517eda456b82025-02-03T01:02:29ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/975971975971Magnetic Resonance Image-Guided Biopsies with a High Detection Rate of Prostate CancerDirk G. Engehausen0Karl Engelhard1Siegfried A. Schwab2Michael Uder3Sven Wach4Bernd Wullich5F. Steffen Krause6Department of Urology, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, GermanyInstitute of Radiology, Martha-Maria Hospital, Stadenstrasse 60, 90491 Nuremberg, GermanyInstitute of Radiology, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, GermanyInstitute of Radiology, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, GermanyDepartment of Urology, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, GermanyDepartment of Urology, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, GermanyDepartment of Urology, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, GermanyAim. To explore the potential of transrectal magnetic resonance image- (MRI-) guided biopsies of the prostate in a patient cohort with prior negative ultrasound guided biopsies. Patients and Methods. Ninety-six men with suspected prostate cancer underwent MRI-guided prostate biopsies under real-time imaging control in supine position. Results. Adenocarcinoma of the prostate was detected in 39 of 96 patients. For individual core biopsies, MRI yielded a sensitivity of 93.0% and a specificity of 94.4%. When stratifying patients according to the free-to-total prostate-specific antigen (PSA) ratio, the prostate cancer discovery rate was significantly higher in the group with ratios less than 0.15 (57.1%). Conclusion. MRI-guided biopsy of the prostate is a diagnostic option for patients with suspected prostate cancer and a history of repeatedly negative transrectal ultrasound-guided biopsies. Combined with the free-to-total PSA ratio, it is a highly effective method for detecting prostate cancer.http://dx.doi.org/10.1100/2012/975971 |
| spellingShingle | Dirk G. Engehausen Karl Engelhard Siegfried A. Schwab Michael Uder Sven Wach Bernd Wullich F. Steffen Krause Magnetic Resonance Image-Guided Biopsies with a High Detection Rate of Prostate Cancer The Scientific World Journal |
| title | Magnetic Resonance Image-Guided Biopsies with a High Detection Rate of Prostate Cancer |
| title_full | Magnetic Resonance Image-Guided Biopsies with a High Detection Rate of Prostate Cancer |
| title_fullStr | Magnetic Resonance Image-Guided Biopsies with a High Detection Rate of Prostate Cancer |
| title_full_unstemmed | Magnetic Resonance Image-Guided Biopsies with a High Detection Rate of Prostate Cancer |
| title_short | Magnetic Resonance Image-Guided Biopsies with a High Detection Rate of Prostate Cancer |
| title_sort | magnetic resonance image guided biopsies with a high detection rate of prostate cancer |
| url | http://dx.doi.org/10.1100/2012/975971 |
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