Autoimmune Polyglandular Syndrome Type 3 with Anorexia
A 71-year-old man with diabetes mellitus visited our hospital with complaints of anorexia and weight loss (12 kg/3 months). He had megaloblastic anemia, cobalamin level was low, and autoantibody to intrinsic factor was positive. He was treated with intramuscular cyanocobalamin, and he was able to co...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2012/657156 |
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| author | Toshio Kahara Hitomi Wakakuri Juri Takatsuji Iori Motoo Kosuke R. Shima Kazuhide Ishikura Rika Usuda Yatsugi Noda |
| author_facet | Toshio Kahara Hitomi Wakakuri Juri Takatsuji Iori Motoo Kosuke R. Shima Kazuhide Ishikura Rika Usuda Yatsugi Noda |
| author_sort | Toshio Kahara |
| collection | DOAJ |
| description | A 71-year-old man with diabetes mellitus visited our hospital with complaints of anorexia and weight loss (12 kg/3 months). He had megaloblastic anemia, cobalamin level was low, and autoantibody to intrinsic factor was positive. He was treated with intramuscular cyanocobalamin, and he was able to consume meals. GAD autoantibody and ICA were positive, and he was diagnosed with slowly progressive type 1 diabetes mellitus (SPIDDM). Thyroid autoantibodies were positive. According to these findings, he was diagnosed with autoimmune polyglandular syndrome type 3 with SPIDDM, pernicious anemia, and Hashimoto's thyroiditis. Extended periods of cobalamin deficiency can cause serious complications such as ataxia and dementia, and these complications may not be reversible if replacement therapy with cobalamin is delayed. Although type 1 diabetes mellitus with coexisting pernicious anemia is very rare in Japan, physicians should consider the possibility of pernicious anemia when patients with diabetes mellitus have cryptogenic anorexia with the finding of significant macrocytosis (MCV > 100 fL). |
| format | Article |
| id | doaj-art-9a9a82544f414f03ad957a89047e9fba |
| institution | Kabale University |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-9a9a82544f414f03ad957a89047e9fba2025-02-03T01:00:54ZengWileyCase Reports in Endocrinology2090-65012090-651X2012-01-01201210.1155/2012/657156657156Autoimmune Polyglandular Syndrome Type 3 with AnorexiaToshio Kahara0Hitomi Wakakuri1Juri Takatsuji2Iori Motoo3Kosuke R. Shima4Kazuhide Ishikura5Rika Usuda6Yatsugi Noda7Department of Internal Medicine, Toyama Prefectural Central Hospital, 2-2-78 Nishinagae, Toyama 930-8550, JapanDepartment of Internal Medicine, Toyama Prefectural Central Hospital, 2-2-78 Nishinagae, Toyama 930-8550, JapanDepartment of Internal Medicine, Toyama Prefectural Central Hospital, 2-2-78 Nishinagae, Toyama 930-8550, JapanDepartment of Internal Medicine, Toyama Prefectural Central Hospital, 2-2-78 Nishinagae, Toyama 930-8550, JapanDepartment of Internal Medicine, Toyama Prefectural Central Hospital, 2-2-78 Nishinagae, Toyama 930-8550, JapanDepartment of Internal Medicine, Toyama Prefectural Central Hospital, 2-2-78 Nishinagae, Toyama 930-8550, JapanDepartment of Internal Medicine, Toyama Prefectural Central Hospital, 2-2-78 Nishinagae, Toyama 930-8550, JapanDepartment of Internal Medicine, Toyama Prefectural Central Hospital, 2-2-78 Nishinagae, Toyama 930-8550, JapanA 71-year-old man with diabetes mellitus visited our hospital with complaints of anorexia and weight loss (12 kg/3 months). He had megaloblastic anemia, cobalamin level was low, and autoantibody to intrinsic factor was positive. He was treated with intramuscular cyanocobalamin, and he was able to consume meals. GAD autoantibody and ICA were positive, and he was diagnosed with slowly progressive type 1 diabetes mellitus (SPIDDM). Thyroid autoantibodies were positive. According to these findings, he was diagnosed with autoimmune polyglandular syndrome type 3 with SPIDDM, pernicious anemia, and Hashimoto's thyroiditis. Extended periods of cobalamin deficiency can cause serious complications such as ataxia and dementia, and these complications may not be reversible if replacement therapy with cobalamin is delayed. Although type 1 diabetes mellitus with coexisting pernicious anemia is very rare in Japan, physicians should consider the possibility of pernicious anemia when patients with diabetes mellitus have cryptogenic anorexia with the finding of significant macrocytosis (MCV > 100 fL).http://dx.doi.org/10.1155/2012/657156 |
| spellingShingle | Toshio Kahara Hitomi Wakakuri Juri Takatsuji Iori Motoo Kosuke R. Shima Kazuhide Ishikura Rika Usuda Yatsugi Noda Autoimmune Polyglandular Syndrome Type 3 with Anorexia Case Reports in Endocrinology |
| title | Autoimmune Polyglandular Syndrome Type 3 with Anorexia |
| title_full | Autoimmune Polyglandular Syndrome Type 3 with Anorexia |
| title_fullStr | Autoimmune Polyglandular Syndrome Type 3 with Anorexia |
| title_full_unstemmed | Autoimmune Polyglandular Syndrome Type 3 with Anorexia |
| title_short | Autoimmune Polyglandular Syndrome Type 3 with Anorexia |
| title_sort | autoimmune polyglandular syndrome type 3 with anorexia |
| url | http://dx.doi.org/10.1155/2012/657156 |
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