Evaluation and Immunolocalization of BMP4 and FGF8 in Odontogenic Cyst and Tumors
Growth factors like bone morphogenetic protein 4 (BMP4) and fibroblast growth factor 8 (FGF8) play a major role in organogenesis and specifically in odontogenesis. They are also believed to have a role in oncogenesis. Thus, any discrepancies in their standard behavior and activity would lead to seri...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/2018/1204549 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832547305821044736 |
|---|---|
| author | Neeti Swarup Meghanand T. Nayak Zoya Chowdhary Monica Mehendiratta Shikha Khatana Su Jung Choi Chandarani Sagolsem |
| author_facet | Neeti Swarup Meghanand T. Nayak Zoya Chowdhary Monica Mehendiratta Shikha Khatana Su Jung Choi Chandarani Sagolsem |
| author_sort | Neeti Swarup |
| collection | DOAJ |
| description | Growth factors like bone morphogenetic protein 4 (BMP4) and fibroblast growth factor 8 (FGF8) play a major role in organogenesis and specifically in odontogenesis. They are also believed to have a role in oncogenesis. Thus, any discrepancies in their standard behavior and activity would lead to serious abnormalities including odontogenic cyst and tumors. The present research work investigated the expression of BMP4 and FGF8 in odontogenic tumors (OT) and cyst as well as developing tooth germs to elucidate their roles. Dental organs of various odontogenic stages and 30 OTs including solid multicystic ameloblastomas (SMA, 10 cases), ameloblastic fibroma (AF, 10 cases), odontogenic myxoma (OM, 10 cases), and odontogenic cysts: odontogenic keratocyst (OKC, 10 cases) were evaluated in both epithelial and mesenchymal components for the expression of BMP4 and FGF8 using immunohistochemistry. The epithelial nuclear expression of BMP4 was highest in OKC (9 cases) while FGF8 was highest in SMA (10 cases). The mesenchymal nuclear expression of both BMP4 (8 cases) (p=0.001) and FGF8 (9 cases) (p=0.045) were significantly high in OMs among all OTs. Both growth factors were actively expressed in different stages of tooth development. The expression of BMP4 and FGF8 corelates well with the proliferative component of the pathologies, indicating a possible role in the pathogenesis and progression. |
| format | Article |
| id | doaj-art-9a95f686aba84b4988f93a88df998176 |
| institution | Kabale University |
| issn | 2210-7177 2210-7185 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-9a95f686aba84b4988f93a88df9981762025-02-03T06:45:18ZengWileyAnalytical Cellular Pathology2210-71772210-71852018-01-01201810.1155/2018/12045491204549Evaluation and Immunolocalization of BMP4 and FGF8 in Odontogenic Cyst and TumorsNeeti Swarup0Meghanand T. Nayak1Zoya Chowdhary2Monica Mehendiratta3Shikha Khatana4Su Jung Choi5Chandarani Sagolsem6Department of Oral Pathology and Microbiology, Daswani Dental College and Research Centre, Kota, IndiaDepartment of Oral Pathology and Microbiology, Teerthanker Mahaveer Dental College and Research Centre, Moradabad, IndiaDepartment of Periodontology, Indira Gandhi Government Dental College and Hospital, Jammu, IndiaDepartment of Oral Pathology and Microbiology, ITS Dental College, Greater Noida, IndiaDepartment of Oral Pathology and Microbiology, Sudha Rustagi College of Dental Sciences, Faridabad, IndiaDepartment of Oral Pathology, School of Dentistry, Seoul National University, Seoul, Republic of KoreaDepartment of Conservative Dentistry and Endodontics, Daswani Dental College and Research Centre, Kota, IndiaGrowth factors like bone morphogenetic protein 4 (BMP4) and fibroblast growth factor 8 (FGF8) play a major role in organogenesis and specifically in odontogenesis. They are also believed to have a role in oncogenesis. Thus, any discrepancies in their standard behavior and activity would lead to serious abnormalities including odontogenic cyst and tumors. The present research work investigated the expression of BMP4 and FGF8 in odontogenic tumors (OT) and cyst as well as developing tooth germs to elucidate their roles. Dental organs of various odontogenic stages and 30 OTs including solid multicystic ameloblastomas (SMA, 10 cases), ameloblastic fibroma (AF, 10 cases), odontogenic myxoma (OM, 10 cases), and odontogenic cysts: odontogenic keratocyst (OKC, 10 cases) were evaluated in both epithelial and mesenchymal components for the expression of BMP4 and FGF8 using immunohistochemistry. The epithelial nuclear expression of BMP4 was highest in OKC (9 cases) while FGF8 was highest in SMA (10 cases). The mesenchymal nuclear expression of both BMP4 (8 cases) (p=0.001) and FGF8 (9 cases) (p=0.045) were significantly high in OMs among all OTs. Both growth factors were actively expressed in different stages of tooth development. The expression of BMP4 and FGF8 corelates well with the proliferative component of the pathologies, indicating a possible role in the pathogenesis and progression.http://dx.doi.org/10.1155/2018/1204549 |
| spellingShingle | Neeti Swarup Meghanand T. Nayak Zoya Chowdhary Monica Mehendiratta Shikha Khatana Su Jung Choi Chandarani Sagolsem Evaluation and Immunolocalization of BMP4 and FGF8 in Odontogenic Cyst and Tumors Analytical Cellular Pathology |
| title | Evaluation and Immunolocalization of BMP4 and FGF8 in Odontogenic Cyst and Tumors |
| title_full | Evaluation and Immunolocalization of BMP4 and FGF8 in Odontogenic Cyst and Tumors |
| title_fullStr | Evaluation and Immunolocalization of BMP4 and FGF8 in Odontogenic Cyst and Tumors |
| title_full_unstemmed | Evaluation and Immunolocalization of BMP4 and FGF8 in Odontogenic Cyst and Tumors |
| title_short | Evaluation and Immunolocalization of BMP4 and FGF8 in Odontogenic Cyst and Tumors |
| title_sort | evaluation and immunolocalization of bmp4 and fgf8 in odontogenic cyst and tumors |
| url | http://dx.doi.org/10.1155/2018/1204549 |
| work_keys_str_mv | AT neetiswarup evaluationandimmunolocalizationofbmp4andfgf8inodontogeniccystandtumors AT meghanandtnayak evaluationandimmunolocalizationofbmp4andfgf8inodontogeniccystandtumors AT zoyachowdhary evaluationandimmunolocalizationofbmp4andfgf8inodontogeniccystandtumors AT monicamehendiratta evaluationandimmunolocalizationofbmp4andfgf8inodontogeniccystandtumors AT shikhakhatana evaluationandimmunolocalizationofbmp4andfgf8inodontogeniccystandtumors AT sujungchoi evaluationandimmunolocalizationofbmp4andfgf8inodontogeniccystandtumors AT chandaranisagolsem evaluationandimmunolocalizationofbmp4andfgf8inodontogeniccystandtumors |