Abdominal Adiposity Correlates with Adenotonsillectomy Outcome in Obese Adolescents with Severe Obstructive Sleep Apnea
Background. Obese adolescents with Obstructive Sleep Apnea (OSA) have a unique pathophysiology that combines adenotonsillar hypertrophy and increased visceral fat distribution. We hypothesized that in this population waist circumference (WC), as a clinical marker of abdominal fat distribution, corre...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Pulmonary Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/351037 |
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| _version_ | 1832548339665600512 |
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| author | Gustavo Nino Maria J. Gutierrez Anjani Ravindra Cesar L. Nino Carlos E. Rodriguez-Martinez |
| author_facet | Gustavo Nino Maria J. Gutierrez Anjani Ravindra Cesar L. Nino Carlos E. Rodriguez-Martinez |
| author_sort | Gustavo Nino |
| collection | DOAJ |
| description | Background. Obese adolescents with Obstructive Sleep Apnea (OSA) have a unique pathophysiology that combines adenotonsillar hypertrophy and increased visceral fat distribution. We hypothesized that in this population waist circumference (WC), as a clinical marker of abdominal fat distribution, correlates with the likelihood of response to AT. Methods. We conducted a retrospective cohort study of obese adolescents ( percentile) that underwent AT for therapy of severe OSA (). We contrasted WC and covariates in a group of subjects that had complete resolution of severe OSA after AT () with those obtained in subjects with residual OSA after AT (). Multivariate linear and logistic models were built to control possible confounders. Results. WC correlated negatively with a positive AT response in young adolescents and the percentage of improvement in obstructive apnea-hypopnea index (OAHI) after AT (). Extended multivariate analysis demonstrated that the link between WC and AT response was independent of demographic variables, OSA severity, clinical upper airway assessment, obesity severity (BMI), and neck circumference (NC). Conclusion. The results suggest that in obese adolescents, abdominal fat distribution determined by WC may be a useful clinical predictor for residual OSA after AT. |
| format | Article |
| id | doaj-art-9a8f1d75c5894813a2f85eafecf1d963 |
| institution | Kabale University |
| issn | 2090-1836 2090-1844 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Medicine |
| spelling | doaj-art-9a8f1d75c5894813a2f85eafecf1d9632025-02-03T06:14:15ZengWileyPulmonary Medicine2090-18362090-18442012-01-01201210.1155/2012/351037351037Abdominal Adiposity Correlates with Adenotonsillectomy Outcome in Obese Adolescents with Severe Obstructive Sleep ApneaGustavo Nino0Maria J. Gutierrez1Anjani Ravindra2Cesar L. Nino3Carlos E. Rodriguez-Martinez4Penn State Sleep Research and Treatment Center, Pennsylvania State University College of Medicine, Hershey, PA, USADepartment of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA, USADepartment of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA, USADepartment of Electronics Engineering, Javeriana University, Bogota, ColombiaDepartment of Pediatrics, School of Medicine, Universidad Nacional de Colombia, Bogota, ColombiaBackground. Obese adolescents with Obstructive Sleep Apnea (OSA) have a unique pathophysiology that combines adenotonsillar hypertrophy and increased visceral fat distribution. We hypothesized that in this population waist circumference (WC), as a clinical marker of abdominal fat distribution, correlates with the likelihood of response to AT. Methods. We conducted a retrospective cohort study of obese adolescents ( percentile) that underwent AT for therapy of severe OSA (). We contrasted WC and covariates in a group of subjects that had complete resolution of severe OSA after AT () with those obtained in subjects with residual OSA after AT (). Multivariate linear and logistic models were built to control possible confounders. Results. WC correlated negatively with a positive AT response in young adolescents and the percentage of improvement in obstructive apnea-hypopnea index (OAHI) after AT (). Extended multivariate analysis demonstrated that the link between WC and AT response was independent of demographic variables, OSA severity, clinical upper airway assessment, obesity severity (BMI), and neck circumference (NC). Conclusion. The results suggest that in obese adolescents, abdominal fat distribution determined by WC may be a useful clinical predictor for residual OSA after AT.http://dx.doi.org/10.1155/2012/351037 |
| spellingShingle | Gustavo Nino Maria J. Gutierrez Anjani Ravindra Cesar L. Nino Carlos E. Rodriguez-Martinez Abdominal Adiposity Correlates with Adenotonsillectomy Outcome in Obese Adolescents with Severe Obstructive Sleep Apnea Pulmonary Medicine |
| title | Abdominal Adiposity Correlates with Adenotonsillectomy Outcome in Obese Adolescents with Severe Obstructive Sleep Apnea |
| title_full | Abdominal Adiposity Correlates with Adenotonsillectomy Outcome in Obese Adolescents with Severe Obstructive Sleep Apnea |
| title_fullStr | Abdominal Adiposity Correlates with Adenotonsillectomy Outcome in Obese Adolescents with Severe Obstructive Sleep Apnea |
| title_full_unstemmed | Abdominal Adiposity Correlates with Adenotonsillectomy Outcome in Obese Adolescents with Severe Obstructive Sleep Apnea |
| title_short | Abdominal Adiposity Correlates with Adenotonsillectomy Outcome in Obese Adolescents with Severe Obstructive Sleep Apnea |
| title_sort | abdominal adiposity correlates with adenotonsillectomy outcome in obese adolescents with severe obstructive sleep apnea |
| url | http://dx.doi.org/10.1155/2012/351037 |
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