Ketotifen Treatment of Active Colitis in Patients with 5-Aminosalicylate Intolerance
Mast cell stabilizers are commonly used in the treatment of asthma and allergic disorders. Although the role of mucosal mast cells in the pathogenesis of inflammatory bowel disease remains uncertain, mast cell stabilizers have been shown in animal models to attenuate the severity of experimental col...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1998-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1998/398142 |
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| _version_ | 1832548339439108096 |
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| author | John K Marshall E Jan Irvine |
| author_facet | John K Marshall E Jan Irvine |
| author_sort | John K Marshall |
| collection | DOAJ |
| description | Mast cell stabilizers are commonly used in the treatment of asthma and allergic disorders. Although the role of mucosal mast cells in the pathogenesis of inflammatory bowel disease remains uncertain, mast cell stabilizers have been shown in animal models to attenuate the severity of experimental colitis. The authors' experience with ketotifen in three patients - one each with Crohn's disease, ulcerative colitis and collagenous colitis - who had demonstrated allergy to, or intolerance of, 5-aminosalicylic acid is reported. |
| format | Article |
| id | doaj-art-9a87d2aa679248818b39d8ccfe128454 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 1998-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-9a87d2aa679248818b39d8ccfe1284542025-02-03T06:14:15ZengWileyCanadian Journal of Gastroenterology0835-79001998-01-0112427327510.1155/1998/398142Ketotifen Treatment of Active Colitis in Patients with 5-Aminosalicylate IntoleranceJohn K Marshall0E Jan Irvine1Division of Gastroenterology, Department of Medicine, McMaster University, Hamilton, Ontario, CanadaDivision of Gastroenterology, Department of Medicine, McMaster University, Hamilton, Ontario, CanadaMast cell stabilizers are commonly used in the treatment of asthma and allergic disorders. Although the role of mucosal mast cells in the pathogenesis of inflammatory bowel disease remains uncertain, mast cell stabilizers have been shown in animal models to attenuate the severity of experimental colitis. The authors' experience with ketotifen in three patients - one each with Crohn's disease, ulcerative colitis and collagenous colitis - who had demonstrated allergy to, or intolerance of, 5-aminosalicylic acid is reported.http://dx.doi.org/10.1155/1998/398142 |
| spellingShingle | John K Marshall E Jan Irvine Ketotifen Treatment of Active Colitis in Patients with 5-Aminosalicylate Intolerance Canadian Journal of Gastroenterology |
| title | Ketotifen Treatment of Active Colitis in Patients with 5-Aminosalicylate Intolerance |
| title_full | Ketotifen Treatment of Active Colitis in Patients with 5-Aminosalicylate Intolerance |
| title_fullStr | Ketotifen Treatment of Active Colitis in Patients with 5-Aminosalicylate Intolerance |
| title_full_unstemmed | Ketotifen Treatment of Active Colitis in Patients with 5-Aminosalicylate Intolerance |
| title_short | Ketotifen Treatment of Active Colitis in Patients with 5-Aminosalicylate Intolerance |
| title_sort | ketotifen treatment of active colitis in patients with 5 aminosalicylate intolerance |
| url | http://dx.doi.org/10.1155/1998/398142 |
| work_keys_str_mv | AT johnkmarshall ketotifentreatmentofactivecolitisinpatientswith5aminosalicylateintolerance AT ejanirvine ketotifentreatmentofactivecolitisinpatientswith5aminosalicylateintolerance |