Positive association between chronic hepatitis B virus infection and anemia in pregnancy in Southern China
Abstract This observational investigation aimed to explore potential risk factors for anemia in pregnancy. Firstly, a cross-sectional study was conducted, encompassing a review of clinical data of 43,201 pregnant women admitted to the Hainan Women and Children’s Medical Center between January 2017 a...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-024-84927-7 |
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| author | Renliang Huang Zhe Lu Xinze Li Duo Zhou Jing Xu Dan Lin Yunxue Fu Yan Liang Xuexia Li Frank Petersen Qiaomiao Zhou Xinhua Yu |
| author_facet | Renliang Huang Zhe Lu Xinze Li Duo Zhou Jing Xu Dan Lin Yunxue Fu Yan Liang Xuexia Li Frank Petersen Qiaomiao Zhou Xinhua Yu |
| author_sort | Renliang Huang |
| collection | DOAJ |
| description | Abstract This observational investigation aimed to explore potential risk factors for anemia in pregnancy. Firstly, a cross-sectional study was conducted, encompassing a review of clinical data of 43,201 pregnant women admitted to the Hainan Women and Children’s Medical Center between January 2017 and December 2020. Comparison between women with and without anemia in pregnancy revealed significant differences between the two groups concerning age, gestational diabetes, hypothyroidism, hyperthyroidism, chronic hepatitis B virus infection, syphilis infection, and human immunodeficiency virus infection. Multivariable logistic regression analysis showed that chronic hepatitis B virus infection was significantly associated with anemia during pregnancy (AOR 2.97, 95% CI 2.57–3.44, p < 0.0001). Subsequently, a retrospective cohort comprising 86 cases with chronic hepatitis B virus infection and 129 control subjects recruited from the Hainan Women and Children’s Medical Center from November 2021 and January 2023 was examined. Results of the examination revealed a corroborative association between chronic hepatitis B virus infection and anemia in pregnancy (OR 2.13, 95% CI 1.20–3.79, p = 0.0092), particularly manifesting in the third trimester of gestation. Further analysis unveiled distinctive hematological alterations among cases with chronic hepatitis B virus infection, characterized by diminished erythrocyte size and reduced levels of corpuscular hemoglobin. Collectively, these findings underscore a positive association of chronic hepatitis B virus infection with anemia during pregnancy. |
| format | Article |
| id | doaj-art-9a7f8b20b0e6458baea54cffa130aae5 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-9a7f8b20b0e6458baea54cffa130aae52025-01-19T12:24:09ZengNature PortfolioScientific Reports2045-23222025-01-011511710.1038/s41598-024-84927-7Positive association between chronic hepatitis B virus infection and anemia in pregnancy in Southern ChinaRenliang Huang0Zhe Lu1Xinze Li2Duo Zhou3Jing Xu4Dan Lin5Yunxue Fu6Yan Liang7Xuexia Li8Frank Petersen9Qiaomiao Zhou10Xinhua Yu11Hainan Women and Children’s Medical CenterHainan Women and Children’s Medical CenterNHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine, Hainan Medical UniversityHainan Women and Children’s Medical CenterHainan Women and Children’s Medical CenterHainan Women and Children’s Medical CenterHainan Women and Children’s Medical CenterHainan Women and Children’s Medical CenterNHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine, Hainan Medical UniversityPriority Area Chronic Lung Diseases, Research Center Borstel, Leibniz Lung CenterHainan Women and Children’s Medical CenterHainan Women and Children’s Medical CenterAbstract This observational investigation aimed to explore potential risk factors for anemia in pregnancy. Firstly, a cross-sectional study was conducted, encompassing a review of clinical data of 43,201 pregnant women admitted to the Hainan Women and Children’s Medical Center between January 2017 and December 2020. Comparison between women with and without anemia in pregnancy revealed significant differences between the two groups concerning age, gestational diabetes, hypothyroidism, hyperthyroidism, chronic hepatitis B virus infection, syphilis infection, and human immunodeficiency virus infection. Multivariable logistic regression analysis showed that chronic hepatitis B virus infection was significantly associated with anemia during pregnancy (AOR 2.97, 95% CI 2.57–3.44, p < 0.0001). Subsequently, a retrospective cohort comprising 86 cases with chronic hepatitis B virus infection and 129 control subjects recruited from the Hainan Women and Children’s Medical Center from November 2021 and January 2023 was examined. Results of the examination revealed a corroborative association between chronic hepatitis B virus infection and anemia in pregnancy (OR 2.13, 95% CI 1.20–3.79, p = 0.0092), particularly manifesting in the third trimester of gestation. Further analysis unveiled distinctive hematological alterations among cases with chronic hepatitis B virus infection, characterized by diminished erythrocyte size and reduced levels of corpuscular hemoglobin. Collectively, these findings underscore a positive association of chronic hepatitis B virus infection with anemia during pregnancy.https://doi.org/10.1038/s41598-024-84927-7Anemia in pregnancyHepatitis B virusInfectionObservational studyAssociation |
| spellingShingle | Renliang Huang Zhe Lu Xinze Li Duo Zhou Jing Xu Dan Lin Yunxue Fu Yan Liang Xuexia Li Frank Petersen Qiaomiao Zhou Xinhua Yu Positive association between chronic hepatitis B virus infection and anemia in pregnancy in Southern China Scientific Reports Anemia in pregnancy Hepatitis B virus Infection Observational study Association |
| title | Positive association between chronic hepatitis B virus infection and anemia in pregnancy in Southern China |
| title_full | Positive association between chronic hepatitis B virus infection and anemia in pregnancy in Southern China |
| title_fullStr | Positive association between chronic hepatitis B virus infection and anemia in pregnancy in Southern China |
| title_full_unstemmed | Positive association between chronic hepatitis B virus infection and anemia in pregnancy in Southern China |
| title_short | Positive association between chronic hepatitis B virus infection and anemia in pregnancy in Southern China |
| title_sort | positive association between chronic hepatitis b virus infection and anemia in pregnancy in southern china |
| topic | Anemia in pregnancy Hepatitis B virus Infection Observational study Association |
| url | https://doi.org/10.1038/s41598-024-84927-7 |
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