Theoretical perspectives and clinical applications of non-coding RNA in lung cancer metastasis: a systematic review
Abstract Lung cancer is one of the deadliest malignancies worldwide, with distant metastasis being a major cause of death. However, the specific mechanisms of lung cancer metastasis remain unclear. NcRNAs, a widely present type of non-coding RNAs in the body, constitute about 98% of the human genome...
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| Format: | Article |
| Language: | English |
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Springer
2025-02-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-01919-3 |
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| author | Jie Yang Yi Luo Zuhuan Yao Zhaokai Wang Ke Jiang |
| author_facet | Jie Yang Yi Luo Zuhuan Yao Zhaokai Wang Ke Jiang |
| author_sort | Jie Yang |
| collection | DOAJ |
| description | Abstract Lung cancer is one of the deadliest malignancies worldwide, with distant metastasis being a major cause of death. However, the specific mechanisms of lung cancer metastasis remain unclear. NcRNAs, a widely present type of non-coding RNAs in the body, constitute about 98% of the human genome, lacking protein-coding capacity but involved in various cellular processes such as proliferation, apoptosis, invasion, and migration. Studies have shown that ncRNAs play a crucial role in the metastasis of lung cancer, although research in this area is limited. This review summarizes the biological origins and functions of ncRNAs, their specific roles and mechanisms in lung cancer metastasis, and discusses their potential for early screening and therapeutic applications in lung cancer. Furthermore, it outlines the challenges in translating basic advancements of ncRNAs in lung cancer metastasis into clinical practice. |
| format | Article |
| id | doaj-art-9a6eeacb996843d4acf57fde3ca8685c |
| institution | DOAJ |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-9a6eeacb996843d4acf57fde3ca8685c2025-08-20T02:48:16ZengSpringerDiscover Oncology2730-60112025-02-0116112310.1007/s12672-025-01919-3Theoretical perspectives and clinical applications of non-coding RNA in lung cancer metastasis: a systematic reviewJie Yang0Yi Luo1Zuhuan Yao2Zhaokai Wang3Ke Jiang4Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyThe Clinical Medical College, Guizhou Medical UniversityDepartment of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Lung cancer is one of the deadliest malignancies worldwide, with distant metastasis being a major cause of death. However, the specific mechanisms of lung cancer metastasis remain unclear. NcRNAs, a widely present type of non-coding RNAs in the body, constitute about 98% of the human genome, lacking protein-coding capacity but involved in various cellular processes such as proliferation, apoptosis, invasion, and migration. Studies have shown that ncRNAs play a crucial role in the metastasis of lung cancer, although research in this area is limited. This review summarizes the biological origins and functions of ncRNAs, their specific roles and mechanisms in lung cancer metastasis, and discusses their potential for early screening and therapeutic applications in lung cancer. Furthermore, it outlines the challenges in translating basic advancements of ncRNAs in lung cancer metastasis into clinical practice.https://doi.org/10.1007/s12672-025-01919-3Lung cancerMetastasisNon-coding RNAMicroRNALong non-coding RNACircular RNA |
| spellingShingle | Jie Yang Yi Luo Zuhuan Yao Zhaokai Wang Ke Jiang Theoretical perspectives and clinical applications of non-coding RNA in lung cancer metastasis: a systematic review Discover Oncology Lung cancer Metastasis Non-coding RNA MicroRNA Long non-coding RNA Circular RNA |
| title | Theoretical perspectives and clinical applications of non-coding RNA in lung cancer metastasis: a systematic review |
| title_full | Theoretical perspectives and clinical applications of non-coding RNA in lung cancer metastasis: a systematic review |
| title_fullStr | Theoretical perspectives and clinical applications of non-coding RNA in lung cancer metastasis: a systematic review |
| title_full_unstemmed | Theoretical perspectives and clinical applications of non-coding RNA in lung cancer metastasis: a systematic review |
| title_short | Theoretical perspectives and clinical applications of non-coding RNA in lung cancer metastasis: a systematic review |
| title_sort | theoretical perspectives and clinical applications of non coding rna in lung cancer metastasis a systematic review |
| topic | Lung cancer Metastasis Non-coding RNA MicroRNA Long non-coding RNA Circular RNA |
| url | https://doi.org/10.1007/s12672-025-01919-3 |
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