Analysis of the expression of genes involved in proliferation and apoptosis in cervical intraepithelial neoplasias and cancer of the cervix uteri
The viral nature of many female genital cancers is now beyond question. By taking into account this fact, the problem of qualitative assessment ofthenatureofcervicalintraepithelialneoplasia(CIN)anditsfocusonprogressiontoinvasivecarcinomabecomesquitenatu ral.Studiesof a number of biological markers o...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
ABV-press
2014-08-01
|
| Series: | Опухоли женской репродуктивной системы |
| Subjects: | |
| Online Access: | https://ojrs.abvpress.ru/ojrs/article/view/202 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849303320256053248 |
|---|---|
| author | V. K. Bozhenko L. A. Ashrafyan I. B. Antonova N. V. Melnikova O. N. Burmenskaya D. Yu. Trofimov E. A. Kudinova L. Z. Khunova A. V. Slonov O. P. Bliznyukov |
| author_facet | V. K. Bozhenko L. A. Ashrafyan I. B. Antonova N. V. Melnikova O. N. Burmenskaya D. Yu. Trofimov E. A. Kudinova L. Z. Khunova A. V. Slonov O. P. Bliznyukov |
| author_sort | V. K. Bozhenko |
| collection | DOAJ |
| description | The viral nature of many female genital cancers is now beyond question. By taking into account this fact, the problem of qualitative assessment ofthenatureofcervicalintraepithelialneoplasia(CIN)anditsfocusonprogressiontoinvasivecarcinomabecomesquitenatu ral.Studiesof a number of biological markers of carcinogenesis have recently provided a possibility for prospective prediction. The paper con siders the as- pects of importance of the molecular biological markers of proliferation and apoptosis in the etiopathogenesis of genital cancers. It gives the results of examinations of 16 patients with histologically verified squamous cell carcinoma of the cervix uteri, 40 patients di agnosed as having CIN of different grades (CIN-1, CIN-2, CIN-3 — squamous cell carcinoma in situ), and 6 patients with the morphologically unaltered cervi- calepithelium,whosecervicalscrapeswereanalyzedfortheexpressionofthemRNAgenesССNB1,Ki-67,BA G,BCL-2,ESR1,andPRG. It is shown that the molecular genetic findings may be new prognostic markers that reflect the possible disease developmental pathways, sug- gesting the need for further investigation of biomarkers in order to prevent malignancies and to reduce their morbidity. |
| format | Article |
| id | doaj-art-9a65089781ea4d62a4e3a49d7acdf314 |
| institution | Kabale University |
| issn | 1994-4098 1999-8627 |
| language | Russian |
| publishDate | 2014-08-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли женской репродуктивной системы |
| spelling | doaj-art-9a65089781ea4d62a4e3a49d7acdf3142025-08-20T04:00:01ZrusABV-pressОпухоли женской репродуктивной системы1994-40981999-86272014-08-0104727510.17650/1994-4098-2011-0-4-72-75218Analysis of the expression of genes involved in proliferation and apoptosis in cervical intraepithelial neoplasias and cancer of the cervix uteriV. K. Bozhenko0L. A. Ashrafyan1I. B. Antonova2N. V. Melnikova3O. N. Burmenskaya4D. Yu. Trofimov5E. A. Kudinova6L. Z. Khunova7A. V. Slonov8O. P. Bliznyukov9Russian X-Ray Radiology Research Center, Ministry of Health and Social Development of RussiaRussian X-Ray Radiology Research Center, Ministry of Health and Social Development of RussiaRussian X-Ray Radiology Research Center, Ministry of Health and Social Development of RussiaRussian X-Ray Radiology Research Center, Ministry of Health and Social Development of RussiaOAO DNA-Technology, MoscowOAO DNA-Technology, MoscowRussian X-Ray Radiology Research Center, Ministry of Health and Social Development of RussiaRussian X-Ray Radiology Research Center, Ministry of Health and Social Development of RussiaRussian X-Ray Radiology Research Center, Ministry of Health and Social Development of RussiaRussian X-Ray Radiology Research Center, Ministry of Health and Social Development of RussiaThe viral nature of many female genital cancers is now beyond question. By taking into account this fact, the problem of qualitative assessment ofthenatureofcervicalintraepithelialneoplasia(CIN)anditsfocusonprogressiontoinvasivecarcinomabecomesquitenatu ral.Studiesof a number of biological markers of carcinogenesis have recently provided a possibility for prospective prediction. The paper con siders the as- pects of importance of the molecular biological markers of proliferation and apoptosis in the etiopathogenesis of genital cancers. It gives the results of examinations of 16 patients with histologically verified squamous cell carcinoma of the cervix uteri, 40 patients di agnosed as having CIN of different grades (CIN-1, CIN-2, CIN-3 — squamous cell carcinoma in situ), and 6 patients with the morphologically unaltered cervi- calepithelium,whosecervicalscrapeswereanalyzedfortheexpressionofthemRNAgenesССNB1,Ki-67,BA G,BCL-2,ESR1,andPRG. It is shown that the molecular genetic findings may be new prognostic markers that reflect the possible disease developmental pathways, sug- gesting the need for further investigation of biomarkers in order to prevent malignancies and to reduce their morbidity.https://ojrs.abvpress.ru/ojrs/article/view/202cancer of the cervix uteriссnb1ki-67bagbcl-2esr1prghuman papillomavirus |
| spellingShingle | V. K. Bozhenko L. A. Ashrafyan I. B. Antonova N. V. Melnikova O. N. Burmenskaya D. Yu. Trofimov E. A. Kudinova L. Z. Khunova A. V. Slonov O. P. Bliznyukov Analysis of the expression of genes involved in proliferation and apoptosis in cervical intraepithelial neoplasias and cancer of the cervix uteri Опухоли женской репродуктивной системы cancer of the cervix uteri ссnb1 ki-67 bag bcl-2 esr1 prg human papillomavirus |
| title | Analysis of the expression of genes involved in proliferation and apoptosis in cervical intraepithelial neoplasias and cancer of the cervix uteri |
| title_full | Analysis of the expression of genes involved in proliferation and apoptosis in cervical intraepithelial neoplasias and cancer of the cervix uteri |
| title_fullStr | Analysis of the expression of genes involved in proliferation and apoptosis in cervical intraepithelial neoplasias and cancer of the cervix uteri |
| title_full_unstemmed | Analysis of the expression of genes involved in proliferation and apoptosis in cervical intraepithelial neoplasias and cancer of the cervix uteri |
| title_short | Analysis of the expression of genes involved in proliferation and apoptosis in cervical intraepithelial neoplasias and cancer of the cervix uteri |
| title_sort | analysis of the expression of genes involved in proliferation and apoptosis in cervical intraepithelial neoplasias and cancer of the cervix uteri |
| topic | cancer of the cervix uteri ссnb1 ki-67 bag bcl-2 esr1 prg human papillomavirus |
| url | https://ojrs.abvpress.ru/ojrs/article/view/202 |
| work_keys_str_mv | AT vkbozhenko analysisoftheexpressionofgenesinvolvedinproliferationandapoptosisincervicalintraepithelialneoplasiasandcancerofthecervixuteri AT laashrafyan analysisoftheexpressionofgenesinvolvedinproliferationandapoptosisincervicalintraepithelialneoplasiasandcancerofthecervixuteri AT ibantonova analysisoftheexpressionofgenesinvolvedinproliferationandapoptosisincervicalintraepithelialneoplasiasandcancerofthecervixuteri AT nvmelnikova analysisoftheexpressionofgenesinvolvedinproliferationandapoptosisincervicalintraepithelialneoplasiasandcancerofthecervixuteri AT onburmenskaya analysisoftheexpressionofgenesinvolvedinproliferationandapoptosisincervicalintraepithelialneoplasiasandcancerofthecervixuteri AT dyutrofimov analysisoftheexpressionofgenesinvolvedinproliferationandapoptosisincervicalintraepithelialneoplasiasandcancerofthecervixuteri AT eakudinova analysisoftheexpressionofgenesinvolvedinproliferationandapoptosisincervicalintraepithelialneoplasiasandcancerofthecervixuteri AT lzkhunova analysisoftheexpressionofgenesinvolvedinproliferationandapoptosisincervicalintraepithelialneoplasiasandcancerofthecervixuteri AT avslonov analysisoftheexpressionofgenesinvolvedinproliferationandapoptosisincervicalintraepithelialneoplasiasandcancerofthecervixuteri AT opbliznyukov analysisoftheexpressionofgenesinvolvedinproliferationandapoptosisincervicalintraepithelialneoplasiasandcancerofthecervixuteri |