Oral Topical Doxepin Rinse: Anesthetic Effect in Normal Subjects
Oral doxepin rinse has been reported to provide pain relief in patients with oral mucosal lesions due to cancer or cancer therapy. The purpose of this study was to assess the anesthetic effect of doxepin oral rinse in normal subjects to identify the duration of effect and to contrast the anesthetic...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2003-01-01
|
| Series: | Pain Research and Management |
| Online Access: | http://dx.doi.org/10.1155/2003/431308 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832566841883492352 |
|---|---|
| author | Joel B Epstein Edmond L Truelove Hal Oien Nhu D Le Mathew S Epstein |
| author_facet | Joel B Epstein Edmond L Truelove Hal Oien Nhu D Le Mathew S Epstein |
| author_sort | Joel B Epstein |
| collection | DOAJ |
| description | Oral doxepin rinse has been reported to provide pain relief in patients with oral mucosal lesions due to cancer or cancer therapy. The purpose of this study was to assess the anesthetic effect of doxepin oral rinse in normal subjects to identify the duration of effect and to contrast the anesthetic effect with reported pain relief in patients with oral mucosal lesions. Normal volunteers were provided a solution of doxepin (5 mg/mL) for oral rinsing. Oral numbness and adverse effects were recorded for a period of 4 h after rinsing. Doxepin rinse resulted in mucosal anesthesia in all subjects. Sedation/fatigue was reported in four of seven subjects. There were no taste complaints and no nausea reported. The limited duration of numbness/anesthesia in normal subjects compared with prior studies showing pain relief for more than 3 h in patients with mucosal lesions, suggests that the extended duration of pain relief in patients was due to analgesic effects rather than anesthetic effects. The majority of normal subjects reported sedation after use, but this was less common in patients with mucosal lesions. |
| format | Article |
| id | doaj-art-9a5882bf63824992a3243ab39ec88731 |
| institution | Kabale University |
| issn | 1203-6765 |
| language | English |
| publishDate | 2003-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pain Research and Management |
| spelling | doaj-art-9a5882bf63824992a3243ab39ec887312025-02-03T01:03:01ZengWileyPain Research and Management1203-67652003-01-018419519710.1155/2003/431308Oral Topical Doxepin Rinse: Anesthetic Effect in Normal SubjectsJoel B Epstein0Edmond L Truelove1Hal Oien2Nhu D Le3Mathew S Epstein4Department of Oral Medicine and Diagnostic Sciences, College of Dentistry, University of Illinois, Chicago, Illinois, USADepartment of Oral Medicine, University of Washington, Seattle, Washington, USABeaverton, Oregon, USACancer Control Research, British Columbia Cancer Agency, Vancouver, British Columbia, CanadaFred Hutchinson Cancer Research Center, Seattle, Washington, USAOral doxepin rinse has been reported to provide pain relief in patients with oral mucosal lesions due to cancer or cancer therapy. The purpose of this study was to assess the anesthetic effect of doxepin oral rinse in normal subjects to identify the duration of effect and to contrast the anesthetic effect with reported pain relief in patients with oral mucosal lesions. Normal volunteers were provided a solution of doxepin (5 mg/mL) for oral rinsing. Oral numbness and adverse effects were recorded for a period of 4 h after rinsing. Doxepin rinse resulted in mucosal anesthesia in all subjects. Sedation/fatigue was reported in four of seven subjects. There were no taste complaints and no nausea reported. The limited duration of numbness/anesthesia in normal subjects compared with prior studies showing pain relief for more than 3 h in patients with mucosal lesions, suggests that the extended duration of pain relief in patients was due to analgesic effects rather than anesthetic effects. The majority of normal subjects reported sedation after use, but this was less common in patients with mucosal lesions.http://dx.doi.org/10.1155/2003/431308 |
| spellingShingle | Joel B Epstein Edmond L Truelove Hal Oien Nhu D Le Mathew S Epstein Oral Topical Doxepin Rinse: Anesthetic Effect in Normal Subjects Pain Research and Management |
| title | Oral Topical Doxepin Rinse: Anesthetic Effect in Normal Subjects |
| title_full | Oral Topical Doxepin Rinse: Anesthetic Effect in Normal Subjects |
| title_fullStr | Oral Topical Doxepin Rinse: Anesthetic Effect in Normal Subjects |
| title_full_unstemmed | Oral Topical Doxepin Rinse: Anesthetic Effect in Normal Subjects |
| title_short | Oral Topical Doxepin Rinse: Anesthetic Effect in Normal Subjects |
| title_sort | oral topical doxepin rinse anesthetic effect in normal subjects |
| url | http://dx.doi.org/10.1155/2003/431308 |
| work_keys_str_mv | AT joelbepstein oraltopicaldoxepinrinseanestheticeffectinnormalsubjects AT edmondltruelove oraltopicaldoxepinrinseanestheticeffectinnormalsubjects AT haloien oraltopicaldoxepinrinseanestheticeffectinnormalsubjects AT nhudle oraltopicaldoxepinrinseanestheticeffectinnormalsubjects AT mathewsepstein oraltopicaldoxepinrinseanestheticeffectinnormalsubjects |