Association of systemic inflammatory response index and stroke: a cross-sectional study of NHANES, 2005–2018
BackgroundMany inflammatory markers like systemic immune-inflammatory index (SII), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) are associated with stroke. However, studies on the relationship between stroke and systemic inflammatory response index (SIRI) are scarce. This s...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1538352/full |
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| author | Aokai Tian Yafang Zheng Jing Jin Chunyuan Huang |
| author_facet | Aokai Tian Yafang Zheng Jing Jin Chunyuan Huang |
| author_sort | Aokai Tian |
| collection | DOAJ |
| description | BackgroundMany inflammatory markers like systemic immune-inflammatory index (SII), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) are associated with stroke. However, studies on the relationship between stroke and systemic inflammatory response index (SIRI) are scarce. This study was aimed at evaluating the potential association of SIRI with stroke.MethodsOur cross-sectional study included adults with sufficient SIRI and stroke data from the 2005-2018 National Health and Nutrition Examination Survey (NHANES). We used multivariable logistic regression, interaction tests, smoothed curve fitting, and subgroup analysis for assessing the independent relationship between SIRI and stroke.ResultsOf 36,176 participants in this study, 1,414 (3.9%) had experienced a stroke. In a fully adjusted model, the systemic inflammatory response index displayed a significant and positive correlation with stroke (odds ratio [OR] = 1.09, 95% confidence interval [CI] = 1.04–1.15, p = 0.0006). Meanwhile, the odds of stroke increased by 39% in the 4th quartile, relative to the 1st quartile (OR = 1.39, 95% CI = 1.17–1.65, p = 0.0002). Additional interaction tests and subgroup analysis revealed that age, sex, race, education, marriage, BMI (body mass index), smoking, diabetes mellitus, hypertension, and coronary heart disease (CHD) were not positively correlated (p interaction >0.05). Moreover, we also found a nonlinear correlation between SIRI and stroke, with an inflection point of 2.17.ConclusionOur results indicate that SIRI is significantly and positively related to stroke; however, its role in stroke needs to be further confirmed by large-scale prospective studies. |
| format | Article |
| id | doaj-art-9a4a92df0efc449ab95e31451ceea8f3 |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-9a4a92df0efc449ab95e31451ceea8f32025-01-31T06:39:51ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-01-011610.3389/fneur.2025.15383521538352Association of systemic inflammatory response index and stroke: a cross-sectional study of NHANES, 2005–2018Aokai TianYafang ZhengJing JinChunyuan HuangBackgroundMany inflammatory markers like systemic immune-inflammatory index (SII), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) are associated with stroke. However, studies on the relationship between stroke and systemic inflammatory response index (SIRI) are scarce. This study was aimed at evaluating the potential association of SIRI with stroke.MethodsOur cross-sectional study included adults with sufficient SIRI and stroke data from the 2005-2018 National Health and Nutrition Examination Survey (NHANES). We used multivariable logistic regression, interaction tests, smoothed curve fitting, and subgroup analysis for assessing the independent relationship between SIRI and stroke.ResultsOf 36,176 participants in this study, 1,414 (3.9%) had experienced a stroke. In a fully adjusted model, the systemic inflammatory response index displayed a significant and positive correlation with stroke (odds ratio [OR] = 1.09, 95% confidence interval [CI] = 1.04–1.15, p = 0.0006). Meanwhile, the odds of stroke increased by 39% in the 4th quartile, relative to the 1st quartile (OR = 1.39, 95% CI = 1.17–1.65, p = 0.0002). Additional interaction tests and subgroup analysis revealed that age, sex, race, education, marriage, BMI (body mass index), smoking, diabetes mellitus, hypertension, and coronary heart disease (CHD) were not positively correlated (p interaction >0.05). Moreover, we also found a nonlinear correlation between SIRI and stroke, with an inflection point of 2.17.ConclusionOur results indicate that SIRI is significantly and positively related to stroke; however, its role in stroke needs to be further confirmed by large-scale prospective studies.https://www.frontiersin.org/articles/10.3389/fneur.2025.1538352/fullsystemic inflammatory response indexstrokecross-sectional studiesNHANESinflammations |
| spellingShingle | Aokai Tian Yafang Zheng Jing Jin Chunyuan Huang Association of systemic inflammatory response index and stroke: a cross-sectional study of NHANES, 2005–2018 Frontiers in Neurology systemic inflammatory response index stroke cross-sectional studies NHANES inflammations |
| title | Association of systemic inflammatory response index and stroke: a cross-sectional study of NHANES, 2005–2018 |
| title_full | Association of systemic inflammatory response index and stroke: a cross-sectional study of NHANES, 2005–2018 |
| title_fullStr | Association of systemic inflammatory response index and stroke: a cross-sectional study of NHANES, 2005–2018 |
| title_full_unstemmed | Association of systemic inflammatory response index and stroke: a cross-sectional study of NHANES, 2005–2018 |
| title_short | Association of systemic inflammatory response index and stroke: a cross-sectional study of NHANES, 2005–2018 |
| title_sort | association of systemic inflammatory response index and stroke a cross sectional study of nhanes 2005 2018 |
| topic | systemic inflammatory response index stroke cross-sectional studies NHANES inflammations |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1538352/full |
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