Two Oral Midazolam Preparations in Pediatric Dental Patients: A Prospective Randomised Clinical Trial
Pharmacological sedation is an alternative behavior management strategy in pediatric dentistry. The aim of this study was to compare the behavioral and physiologic effects of “commercially midazolam syrup” versus “orally administered IV midazolam dosage form (extemporaneous midazolam (EF))” in uncoo...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2015/349795 |
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| author | Katayoun Salem Shaqayegh Kamranzadeh Maryam Kousha Shahnaz Shaeghi Fatemeh AbdollahGorgi |
| author_facet | Katayoun Salem Shaqayegh Kamranzadeh Maryam Kousha Shahnaz Shaeghi Fatemeh AbdollahGorgi |
| author_sort | Katayoun Salem |
| collection | DOAJ |
| description | Pharmacological sedation is an alternative behavior management strategy in pediatric dentistry. The aim of this study was to compare the behavioral and physiologic effects of “commercially midazolam syrup” versus “orally administered IV midazolam dosage form (extemporaneous midazolam (EF))” in uncooperative pediatric dental patients. Eighty-eight children between 4 to 7 years of age received 0.2–0.5 mg/kg midazolam in this parallel trial. Physiologic parameters were recorded at baseline and every 15 minutes. Behavior assessment was conducted objectively by Houpt scale throughout the sedation and North Carolina at baseline and during injection and cavity preparation. No significant difference in behavior was noted by Houpt or North Carolina scale. Acceptable behavior (excellent, very good, and good) was observed in 90.9% of syrup and 79.5% of EF subjects, respectively. Physiological parameters remained in normal range without significant difference between groups and no adverse effect was observed. It is concluded that EF midazolam preparation can be used as an acceptable alternative to midazolam syrup. |
| format | Article |
| id | doaj-art-9a3f9e033e9d4755be82894b2c5b610f |
| institution | Kabale University |
| issn | 1687-9740 1687-9759 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj-art-9a3f9e033e9d4755be82894b2c5b610f2025-02-03T05:58:26ZengWileyInternational Journal of Pediatrics1687-97401687-97592015-01-01201510.1155/2015/349795349795Two Oral Midazolam Preparations in Pediatric Dental Patients: A Prospective Randomised Clinical TrialKatayoun Salem0Shaqayegh Kamranzadeh1Maryam Kousha2Shahnaz Shaeghi3Fatemeh AbdollahGorgi4Department of Pediatric Dentistry and Oro-Maxillofacial Developmental Disease Research Center, Faculty of Dentistry, Guilan University of Medical Sciences, Rasht 4194173774, IranGuilan University of Medical Sciences, Rasht, IranDepartment of Pediatric Psychiatry, Shafa Hospital, Guilan University of Medical Sciences, Rasht, IranDepartment of Pediatric Anesthesiology, Mofid Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranMedical Research Development Center, Mofid Children’s Hospital, Shahid Beheshti University of Medical Sciences, IranPharmacological sedation is an alternative behavior management strategy in pediatric dentistry. The aim of this study was to compare the behavioral and physiologic effects of “commercially midazolam syrup” versus “orally administered IV midazolam dosage form (extemporaneous midazolam (EF))” in uncooperative pediatric dental patients. Eighty-eight children between 4 to 7 years of age received 0.2–0.5 mg/kg midazolam in this parallel trial. Physiologic parameters were recorded at baseline and every 15 minutes. Behavior assessment was conducted objectively by Houpt scale throughout the sedation and North Carolina at baseline and during injection and cavity preparation. No significant difference in behavior was noted by Houpt or North Carolina scale. Acceptable behavior (excellent, very good, and good) was observed in 90.9% of syrup and 79.5% of EF subjects, respectively. Physiological parameters remained in normal range without significant difference between groups and no adverse effect was observed. It is concluded that EF midazolam preparation can be used as an acceptable alternative to midazolam syrup.http://dx.doi.org/10.1155/2015/349795 |
| spellingShingle | Katayoun Salem Shaqayegh Kamranzadeh Maryam Kousha Shahnaz Shaeghi Fatemeh AbdollahGorgi Two Oral Midazolam Preparations in Pediatric Dental Patients: A Prospective Randomised Clinical Trial International Journal of Pediatrics |
| title | Two Oral Midazolam Preparations in Pediatric Dental Patients: A Prospective Randomised Clinical Trial |
| title_full | Two Oral Midazolam Preparations in Pediatric Dental Patients: A Prospective Randomised Clinical Trial |
| title_fullStr | Two Oral Midazolam Preparations in Pediatric Dental Patients: A Prospective Randomised Clinical Trial |
| title_full_unstemmed | Two Oral Midazolam Preparations in Pediatric Dental Patients: A Prospective Randomised Clinical Trial |
| title_short | Two Oral Midazolam Preparations in Pediatric Dental Patients: A Prospective Randomised Clinical Trial |
| title_sort | two oral midazolam preparations in pediatric dental patients a prospective randomised clinical trial |
| url | http://dx.doi.org/10.1155/2015/349795 |
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