Increased Frequency of Circulating Follicular Helper T Cells in Patients with Rheumatoid Arthritis
Follicular helper T (Tfh) cells are recognized as a distinct CD4+ helper T-cell subset, which provides for B-cell activation and production of specific antibody responses, and play a critical role in the development of autoimmune disease. So far, only one study investigated the circulating Tfh cells...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/827480 |
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| author | Jie Ma Chenlu Zhu Bin Ma Jie Tian Samuel Essien Baidoo Chaoming Mao Wei Wu Jianguo Chen Jia Tong Min Yang Zhijun Jiao Huaxi Xu Liwei Lu Shengjun Wang |
| author_facet | Jie Ma Chenlu Zhu Bin Ma Jie Tian Samuel Essien Baidoo Chaoming Mao Wei Wu Jianguo Chen Jia Tong Min Yang Zhijun Jiao Huaxi Xu Liwei Lu Shengjun Wang |
| author_sort | Jie Ma |
| collection | DOAJ |
| description | Follicular helper T (Tfh) cells are recognized as a distinct CD4+ helper T-cell subset, which provides for B-cell activation and production of specific antibody responses, and play a critical role in the development of autoimmune disease. So far, only one study investigated the circulating Tfh cells increased in a subset of SLE patients. Since relatively little is known about the Tfh cells in rheumatoid arthritis (RA) patients, in this study, Tfh-cell frequency, related cytokine IL-21, and transcription factor Bcl-6 were investigated in 53 patients with RA and 31 health controls. Firstly, we found that the frequency of CD4+CXCR5+ICOShigh
Tfh cells was increased significantly in the peripheral blood of RA patients, compared with that in healthy controls. It is known that Tfh cells are critical for directing the development of an antibody response by germinal centers B cells; secondly, we observed that the Tfh-cell frequency is accompanied by the level of anti-CCP antibody in RA patients. Furthermore, expression of Bcl-6 mRNA and plasma IL-21 concentrations in RA patients was increased. Taken together, these findings have shown that the increased frequency of circulating Tfh cells is correlated with elevated levels of anti-CCP antibody, indicating the possible involvement of Tfh cells in the disease progression of RA. |
| format | Article |
| id | doaj-art-9a3a2177a96a4bcf819c4701505f5e53 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-9a3a2177a96a4bcf819c4701505f5e532025-02-03T05:48:02ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/827480827480Increased Frequency of Circulating Follicular Helper T Cells in Patients with Rheumatoid ArthritisJie Ma0Chenlu Zhu1Bin Ma2Jie Tian3Samuel Essien Baidoo4Chaoming Mao5Wei Wu6Jianguo Chen7Jia Tong8Min Yang9Zhijun Jiao10Huaxi Xu11Liwei Lu12Shengjun Wang13Department of Laboratory Medicine, The Affiliated People’s Hospital, and School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang 212013, ChinaDepartment of Laboratory Medicine, The Affiliated People’s Hospital, and School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang 212013, ChinaDepartment of Laboratory Medicine, The Affiliated People’s Hospital, and School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang 212013, ChinaDepartment of Laboratory Medicine, The Affiliated People’s Hospital, and School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang 212013, ChinaDepartment of Laboratory Medicine, The Affiliated People’s Hospital, and School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang 212013, ChinaDepartment of Nuclear Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, ChinaDepartment of Nuclear Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, ChinaDepartment of Laboratory Medicine, The Affiliated People’s Hospital, and School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang 212013, ChinaDepartment of Laboratory Medicine, The Affiliated People’s Hospital, and School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang 212013, ChinaDepartment of Pathology and Center of Infection and Immunology, The University of Hong Kong, Hong KongZhenjiang Key Laboratory of Medical Immunology, Affiliated Hospital of Jiangsu University, Zhenjiang, ChinaDepartment of Laboratory Medicine, The Affiliated People’s Hospital, and School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang 212013, ChinaDepartment of Pathology and Center of Infection and Immunology, The University of Hong Kong, Hong KongDepartment of Laboratory Medicine, The Affiliated People’s Hospital, and School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang 212013, ChinaFollicular helper T (Tfh) cells are recognized as a distinct CD4+ helper T-cell subset, which provides for B-cell activation and production of specific antibody responses, and play a critical role in the development of autoimmune disease. So far, only one study investigated the circulating Tfh cells increased in a subset of SLE patients. Since relatively little is known about the Tfh cells in rheumatoid arthritis (RA) patients, in this study, Tfh-cell frequency, related cytokine IL-21, and transcription factor Bcl-6 were investigated in 53 patients with RA and 31 health controls. Firstly, we found that the frequency of CD4+CXCR5+ICOShigh Tfh cells was increased significantly in the peripheral blood of RA patients, compared with that in healthy controls. It is known that Tfh cells are critical for directing the development of an antibody response by germinal centers B cells; secondly, we observed that the Tfh-cell frequency is accompanied by the level of anti-CCP antibody in RA patients. Furthermore, expression of Bcl-6 mRNA and plasma IL-21 concentrations in RA patients was increased. Taken together, these findings have shown that the increased frequency of circulating Tfh cells is correlated with elevated levels of anti-CCP antibody, indicating the possible involvement of Tfh cells in the disease progression of RA.http://dx.doi.org/10.1155/2012/827480 |
| spellingShingle | Jie Ma Chenlu Zhu Bin Ma Jie Tian Samuel Essien Baidoo Chaoming Mao Wei Wu Jianguo Chen Jia Tong Min Yang Zhijun Jiao Huaxi Xu Liwei Lu Shengjun Wang Increased Frequency of Circulating Follicular Helper T Cells in Patients with Rheumatoid Arthritis Clinical and Developmental Immunology |
| title | Increased Frequency of Circulating Follicular Helper T Cells in Patients with Rheumatoid Arthritis |
| title_full | Increased Frequency of Circulating Follicular Helper T Cells in Patients with Rheumatoid Arthritis |
| title_fullStr | Increased Frequency of Circulating Follicular Helper T Cells in Patients with Rheumatoid Arthritis |
| title_full_unstemmed | Increased Frequency of Circulating Follicular Helper T Cells in Patients with Rheumatoid Arthritis |
| title_short | Increased Frequency of Circulating Follicular Helper T Cells in Patients with Rheumatoid Arthritis |
| title_sort | increased frequency of circulating follicular helper t cells in patients with rheumatoid arthritis |
| url | http://dx.doi.org/10.1155/2012/827480 |
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