Macroporous Composite Cryogels with Embedded Polystyrene Divinylbenzene Microparticles for the Adsorption of Toxic Metabolites from Blood
Composite monolithic adsorbents were prepared by the incorporation of neutral polystyrene divinylbenzene (PS-DVB) microparticles into macroporous polymer structures produced by cryogelation of agarose or poly(vinyl alcohol). The composite materials exhibited excellent flow-through properties. Scanni...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2013/348412 |
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| author | Tanja Eichhorn Alexander E. Ivanov Maria B. Dainiak André Leistner Ingrid Linsberger Hans Jungvid Sergey V. Mikhalovsky Viktoria Weber |
| author_facet | Tanja Eichhorn Alexander E. Ivanov Maria B. Dainiak André Leistner Ingrid Linsberger Hans Jungvid Sergey V. Mikhalovsky Viktoria Weber |
| author_sort | Tanja Eichhorn |
| collection | DOAJ |
| description | Composite monolithic adsorbents were prepared by the incorporation of neutral polystyrene divinylbenzene (PS-DVB) microparticles into macroporous polymer structures produced by cryogelation of agarose or poly(vinyl alcohol). The composite materials exhibited excellent flow-through properties. Scanning electron microscopy of the composite cryogels revealed that the microparticles were covered by thin films of poly(vinyl alcohol) or agarose and thus were withheld in the monolith structure. Plain PS-DVB microparticles showed efficient adsorption of albumin-bound toxins related to liver failure (bilirubin and cholic acid) and of cytokines (tumor necrosis factor-alpha and interleukin-6). The rates of adsorption and the amount of adsorbed factors were lower for the embedded microparticles as compared to the parent PS-DVB microparticles, indicating the importance of the accessibility of the adsorbent pores. Still, the macroporous composite materials showed efficient adsorption of albumin-bound toxins related to liver failure as well as efficient binding of cytokines, combined with good blood compatibility. Thus, the incorporation of microparticles into macroporous polymer structures may provide an option for the development of adsorption modules for extracorporeal blood purification. |
| format | Article |
| id | doaj-art-9a37799ccdc74c16bcf34a04d822c58b |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-9a37799ccdc74c16bcf34a04d822c58b2025-02-03T05:50:23ZengWileyJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/348412348412Macroporous Composite Cryogels with Embedded Polystyrene Divinylbenzene Microparticles for the Adsorption of Toxic Metabolites from BloodTanja Eichhorn0Alexander E. Ivanov1Maria B. Dainiak2André Leistner3Ingrid Linsberger4Hans Jungvid5Sergey V. Mikhalovsky6Viktoria Weber7Center for Biomedical Technology, Danube University Krems, Dr.-Karl-Dorrek-Strasse 30, 3500 Krems, AustriaProtista Biotechnology AB, Kvarngatan 2, 26734 Bjuv, SwedenProtista Biotechnology AB, Kvarngatan 2, 26734 Bjuv, SwedenPolymerics GmbH, Landsberger Allee 378, 12681 Berlin, GermanyCenter for Biomedical Technology, Danube University Krems, Dr.-Karl-Dorrek-Strasse 30, 3500 Krems, AustriaProtista Biotechnology AB, Kvarngatan 2, 26734 Bjuv, SwedenSchool of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton BN2 4GJ, UKCenter for Biomedical Technology, Danube University Krems, Dr.-Karl-Dorrek-Strasse 30, 3500 Krems, AustriaComposite monolithic adsorbents were prepared by the incorporation of neutral polystyrene divinylbenzene (PS-DVB) microparticles into macroporous polymer structures produced by cryogelation of agarose or poly(vinyl alcohol). The composite materials exhibited excellent flow-through properties. Scanning electron microscopy of the composite cryogels revealed that the microparticles were covered by thin films of poly(vinyl alcohol) or agarose and thus were withheld in the monolith structure. Plain PS-DVB microparticles showed efficient adsorption of albumin-bound toxins related to liver failure (bilirubin and cholic acid) and of cytokines (tumor necrosis factor-alpha and interleukin-6). The rates of adsorption and the amount of adsorbed factors were lower for the embedded microparticles as compared to the parent PS-DVB microparticles, indicating the importance of the accessibility of the adsorbent pores. Still, the macroporous composite materials showed efficient adsorption of albumin-bound toxins related to liver failure as well as efficient binding of cytokines, combined with good blood compatibility. Thus, the incorporation of microparticles into macroporous polymer structures may provide an option for the development of adsorption modules for extracorporeal blood purification.http://dx.doi.org/10.1155/2013/348412 |
| spellingShingle | Tanja Eichhorn Alexander E. Ivanov Maria B. Dainiak André Leistner Ingrid Linsberger Hans Jungvid Sergey V. Mikhalovsky Viktoria Weber Macroporous Composite Cryogels with Embedded Polystyrene Divinylbenzene Microparticles for the Adsorption of Toxic Metabolites from Blood Journal of Chemistry |
| title | Macroporous Composite Cryogels with Embedded Polystyrene Divinylbenzene Microparticles for the Adsorption of Toxic Metabolites from Blood |
| title_full | Macroporous Composite Cryogels with Embedded Polystyrene Divinylbenzene Microparticles for the Adsorption of Toxic Metabolites from Blood |
| title_fullStr | Macroporous Composite Cryogels with Embedded Polystyrene Divinylbenzene Microparticles for the Adsorption of Toxic Metabolites from Blood |
| title_full_unstemmed | Macroporous Composite Cryogels with Embedded Polystyrene Divinylbenzene Microparticles for the Adsorption of Toxic Metabolites from Blood |
| title_short | Macroporous Composite Cryogels with Embedded Polystyrene Divinylbenzene Microparticles for the Adsorption of Toxic Metabolites from Blood |
| title_sort | macroporous composite cryogels with embedded polystyrene divinylbenzene microparticles for the adsorption of toxic metabolites from blood |
| url | http://dx.doi.org/10.1155/2013/348412 |
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