A Network Investigation on Idiopathic Hypogonadotropic Hypogonadism in China
Idiopathic hypogonadotropic hypogonadism (IHH) is a rare condition in which puberty does not take place naturally. We aimed to develop and follow an internet-based cohort and to improve our understanding of the disease. We established an internet-based questionnaire survey. A total of 74 male IHH pa...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2013/591012 |
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| author | Weiwei Zhao Hongying Ye Xiaolong Zhao Zhaoyun Zhang Shouyue Sun Yiran Jiang Min He Cheng Xu Renming Hu Yiming Li |
| author_facet | Weiwei Zhao Hongying Ye Xiaolong Zhao Zhaoyun Zhang Shouyue Sun Yiran Jiang Min He Cheng Xu Renming Hu Yiming Li |
| author_sort | Weiwei Zhao |
| collection | DOAJ |
| description | Idiopathic hypogonadotropic hypogonadism (IHH) is a rare condition in which puberty does not take place naturally. We aimed to develop and follow an internet-based cohort and to improve our understanding of the disease. We established an internet-based questionnaire survey. A total of 74 male IHH patients were recruited from the Chinese largest IHH network social group. The clinical symptoms before treatment mainly included small testis, underdeveloped secondary sexual characteristics, and sexual dysfunction. After treatment, the penis length, testicular volume, external genital organ development, pubic hair, beard, laryngeal prominence, erection, and spermatorrhea were improved significantly (P<0.001). 18.9% of the patients completed fertility; however, more than half of the patients still complained of poor happiness and low physical strength. In addition, improvements in penis and pubic hair development, testosterone normalization and the physical strength in IHH patients who received gonadotropin and androgen replacement therapy were better than in those who received single gonadotropin therapy (P<0.05 for all). In conclusion, disease-specific network investigation can be used as an alternative method of medical research for rare diseases. The results of our cross-sectional study showed the effectiveness of hormone replacement therapy for IHH and implied that gonadotropin and androgen replacement therapy may be superior to gonadotropin treatment alone. |
| format | Article |
| id | doaj-art-9a318b57e2194869ad6d7ec02fb2f1b2 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-9a318b57e2194869ad6d7ec02fb2f1b22025-02-03T00:59:46ZengWileyInternational Journal of Endocrinology1687-83371687-83452013-01-01201310.1155/2013/591012591012A Network Investigation on Idiopathic Hypogonadotropic Hypogonadism in ChinaWeiwei Zhao0Hongying Ye1Xiaolong Zhao2Zhaoyun Zhang3Shouyue Sun4Yiran Jiang5Min He6Cheng Xu7Renming Hu8Yiming Li9Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Endocrinology & Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, ChinaDepartment of Endocrinology & Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, ChinaDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai 200040, ChinaIdiopathic hypogonadotropic hypogonadism (IHH) is a rare condition in which puberty does not take place naturally. We aimed to develop and follow an internet-based cohort and to improve our understanding of the disease. We established an internet-based questionnaire survey. A total of 74 male IHH patients were recruited from the Chinese largest IHH network social group. The clinical symptoms before treatment mainly included small testis, underdeveloped secondary sexual characteristics, and sexual dysfunction. After treatment, the penis length, testicular volume, external genital organ development, pubic hair, beard, laryngeal prominence, erection, and spermatorrhea were improved significantly (P<0.001). 18.9% of the patients completed fertility; however, more than half of the patients still complained of poor happiness and low physical strength. In addition, improvements in penis and pubic hair development, testosterone normalization and the physical strength in IHH patients who received gonadotropin and androgen replacement therapy were better than in those who received single gonadotropin therapy (P<0.05 for all). In conclusion, disease-specific network investigation can be used as an alternative method of medical research for rare diseases. The results of our cross-sectional study showed the effectiveness of hormone replacement therapy for IHH and implied that gonadotropin and androgen replacement therapy may be superior to gonadotropin treatment alone.http://dx.doi.org/10.1155/2013/591012 |
| spellingShingle | Weiwei Zhao Hongying Ye Xiaolong Zhao Zhaoyun Zhang Shouyue Sun Yiran Jiang Min He Cheng Xu Renming Hu Yiming Li A Network Investigation on Idiopathic Hypogonadotropic Hypogonadism in China International Journal of Endocrinology |
| title | A Network Investigation on Idiopathic Hypogonadotropic Hypogonadism in China |
| title_full | A Network Investigation on Idiopathic Hypogonadotropic Hypogonadism in China |
| title_fullStr | A Network Investigation on Idiopathic Hypogonadotropic Hypogonadism in China |
| title_full_unstemmed | A Network Investigation on Idiopathic Hypogonadotropic Hypogonadism in China |
| title_short | A Network Investigation on Idiopathic Hypogonadotropic Hypogonadism in China |
| title_sort | network investigation on idiopathic hypogonadotropic hypogonadism in china |
| url | http://dx.doi.org/10.1155/2013/591012 |
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