Proteomic pathways across the ejection fraction spectrum in patients with heart failure and diabetes mellitus: an EXSCEL trial substudy

Abstract Ejection fraction (EF) is a key component of heart failure (HF) classification. However, the biologic basis of HF with mildly reduced EF (HFmrEF) as a distinct biologic entity distinct from HF with preserved EF (HFpEF) and reduced EF (HFrEF) has not been well characterized. The EXSCEL trial...

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Main Authors: Anthony E. Peters, Maggie Nguyen, Jennifer B. Green, Ewan R Pearson, John B. Buse, Harald Sourij, Adrian F. Hernandez, Naveed Sattar, Rury R. Holman, Robert J. Mentz, Svati H. Shah
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-14414-0
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