A Case of Hemophagocytic Syndrome due to Tuberculosis: Uncommon Manifestation of a Common Disease
Hemophagocytic syndrome, also known as hemophagocytic lymphohistiocytosis (HLH), is the manifestation of immune dysregulation. It is associated with ineffective but exaggerated immune response and infiltration of active lymphocytes and histiocytes in various organs. This devastating clinical conditi...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2014/613845 |
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| author | Arijit Singha Adreesh Mukherjee Riddhi Dasgupta Tapas Das |
| author_facet | Arijit Singha Adreesh Mukherjee Riddhi Dasgupta Tapas Das |
| author_sort | Arijit Singha |
| collection | DOAJ |
| description | Hemophagocytic syndrome, also known as hemophagocytic lymphohistiocytosis (HLH), is the manifestation of immune dysregulation. It is associated with ineffective but exaggerated immune response and infiltration of active lymphocytes and histiocytes in various organs. This devastating clinical condition has myriad of clinical and biochemical manifestations such as fever, splenomegaly, pancytopenia, hypertrygliceridemia, and hyperferritinemia. It can be either primary or secondary. Primary HLH usually presents in childhood. Secondary HLH occurs due to infection mostly viruses but other aetiologies are also important as early detection and treatment may improve survival. Hemophagocytosis due to tuberculosis is uncommon. Only handful of cases have been reported mostly in immunocompromised patients. We report a case of hemophagocytic syndrome associated with disseminated tuberculosis in an immunocompetent women highlighting early diagnosis and treatment is a demanding need in this devastating disease. |
| format | Article |
| id | doaj-art-9a2d7d9e3ddf4cb994c53a5760dd473c |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-9a2d7d9e3ddf4cb994c53a5760dd473c2025-02-03T05:43:42ZengWileyCase Reports in Medicine1687-96271687-96352014-01-01201410.1155/2014/613845613845A Case of Hemophagocytic Syndrome due to Tuberculosis: Uncommon Manifestation of a Common DiseaseArijit Singha0Adreesh Mukherjee1Riddhi Dasgupta2Tapas Das3Department of Medicine, Institute of Post Graduate Medical Education and Research and SSKM Hospital, 242 AJC Bose Road, Kolkata, West Bengal 700020, IndiaDepartment of Medicine, Institute of Post Graduate Medical Education and Research and SSKM Hospital, 242 AJC Bose Road, Kolkata, West Bengal 700020, IndiaDepartment of Medicine, Institute of Post Graduate Medical Education and Research and SSKM Hospital, 242 AJC Bose Road, Kolkata, West Bengal 700020, IndiaDepartment of Medicine, Institute of Post Graduate Medical Education and Research and SSKM Hospital, 242 AJC Bose Road, Kolkata, West Bengal 700020, IndiaHemophagocytic syndrome, also known as hemophagocytic lymphohistiocytosis (HLH), is the manifestation of immune dysregulation. It is associated with ineffective but exaggerated immune response and infiltration of active lymphocytes and histiocytes in various organs. This devastating clinical condition has myriad of clinical and biochemical manifestations such as fever, splenomegaly, pancytopenia, hypertrygliceridemia, and hyperferritinemia. It can be either primary or secondary. Primary HLH usually presents in childhood. Secondary HLH occurs due to infection mostly viruses but other aetiologies are also important as early detection and treatment may improve survival. Hemophagocytosis due to tuberculosis is uncommon. Only handful of cases have been reported mostly in immunocompromised patients. We report a case of hemophagocytic syndrome associated with disseminated tuberculosis in an immunocompetent women highlighting early diagnosis and treatment is a demanding need in this devastating disease.http://dx.doi.org/10.1155/2014/613845 |
| spellingShingle | Arijit Singha Adreesh Mukherjee Riddhi Dasgupta Tapas Das A Case of Hemophagocytic Syndrome due to Tuberculosis: Uncommon Manifestation of a Common Disease Case Reports in Medicine |
| title | A Case of Hemophagocytic Syndrome due to Tuberculosis: Uncommon Manifestation of a Common Disease |
| title_full | A Case of Hemophagocytic Syndrome due to Tuberculosis: Uncommon Manifestation of a Common Disease |
| title_fullStr | A Case of Hemophagocytic Syndrome due to Tuberculosis: Uncommon Manifestation of a Common Disease |
| title_full_unstemmed | A Case of Hemophagocytic Syndrome due to Tuberculosis: Uncommon Manifestation of a Common Disease |
| title_short | A Case of Hemophagocytic Syndrome due to Tuberculosis: Uncommon Manifestation of a Common Disease |
| title_sort | case of hemophagocytic syndrome due to tuberculosis uncommon manifestation of a common disease |
| url | http://dx.doi.org/10.1155/2014/613845 |
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