The Role of MIF in Type 1 and Type 2 Diabetes Mellitus
Autoimmunity and chronic low-grade inflammation are hallmarks of diabetes mellitus type one (T1DM) and type two (T2DM), respectively. Both processes are orchestrated by inflammatory cytokines, including the macrophage migration inhibitory factor (MIF). To date, MIF has been implicated in both types...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2014/804519 |
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| _version_ | 1832555872740442112 |
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| author | Yuriko I. Sánchez-Zamora Miriam Rodriguez-Sosa |
| author_facet | Yuriko I. Sánchez-Zamora Miriam Rodriguez-Sosa |
| author_sort | Yuriko I. Sánchez-Zamora |
| collection | DOAJ |
| description | Autoimmunity and chronic low-grade inflammation are hallmarks of diabetes mellitus type one (T1DM) and type two (T2DM), respectively. Both processes are orchestrated by inflammatory cytokines, including the macrophage migration inhibitory factor (MIF). To date, MIF has been implicated in both types of diabetes; therefore, understanding the role of MIF could affect our understanding of the autoimmune or inflammatory responses that influence diabetic pathology. This review highlights our current knowledge about the involvement of MIF in both types of diabetes in the clinical environment and in experimental disease models. |
| format | Article |
| id | doaj-art-9a2ab5e40eb8485dafe83bda09dabc58 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-9a2ab5e40eb8485dafe83bda09dabc582025-02-03T05:46:56ZengWileyJournal of Diabetes Research2314-67452314-67532014-01-01201410.1155/2014/804519804519The Role of MIF in Type 1 and Type 2 Diabetes MellitusYuriko I. Sánchez-Zamora0Miriam Rodriguez-Sosa1Unidad de Biomedicina, Facultad de Estudios Superiores-Iztacala, Universidad Nacional Autónoma de México, Avenida de los Barrios No. 1, Los Reyes Iztacala, 54090 Tlalnepantla, MEX, MexicoUnidad de Biomedicina, Facultad de Estudios Superiores-Iztacala, Universidad Nacional Autónoma de México, Avenida de los Barrios No. 1, Los Reyes Iztacala, 54090 Tlalnepantla, MEX, MexicoAutoimmunity and chronic low-grade inflammation are hallmarks of diabetes mellitus type one (T1DM) and type two (T2DM), respectively. Both processes are orchestrated by inflammatory cytokines, including the macrophage migration inhibitory factor (MIF). To date, MIF has been implicated in both types of diabetes; therefore, understanding the role of MIF could affect our understanding of the autoimmune or inflammatory responses that influence diabetic pathology. This review highlights our current knowledge about the involvement of MIF in both types of diabetes in the clinical environment and in experimental disease models.http://dx.doi.org/10.1155/2014/804519 |
| spellingShingle | Yuriko I. Sánchez-Zamora Miriam Rodriguez-Sosa The Role of MIF in Type 1 and Type 2 Diabetes Mellitus Journal of Diabetes Research |
| title | The Role of MIF in Type 1 and Type 2 Diabetes Mellitus |
| title_full | The Role of MIF in Type 1 and Type 2 Diabetes Mellitus |
| title_fullStr | The Role of MIF in Type 1 and Type 2 Diabetes Mellitus |
| title_full_unstemmed | The Role of MIF in Type 1 and Type 2 Diabetes Mellitus |
| title_short | The Role of MIF in Type 1 and Type 2 Diabetes Mellitus |
| title_sort | role of mif in type 1 and type 2 diabetes mellitus |
| url | http://dx.doi.org/10.1155/2014/804519 |
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