Twenty-Four-Hour Urinary Aldosterone Predicts Inappropriate Left Ventricular Mass Index in Patients with Primary Aldosteronism
Objective. Primary aldosteronism (PA) is associated with inappropriate left ventricular hypertrophy (LVH) in relation to a given gender and body size. There is no ideal parameter to predict the presence of LVH or inappropriate LVH in patients with PA. We investigate the performance of 24-hour urinar...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/294594 |
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| author | Chi-Sheng Hung Yi-Lwun Ho Yi-Yao Chang Vin-Cent Wu Xue-Ming Wu Jen-Kuang Lee Shih-Chieh Chueh Yen-Hung Lin Yuan-Shian Changh Shao-Yu Yang Ya-Hui Hu Ming-Jai Sui Ming-Fong Chen Kwan-Dun Wu |
| author_facet | Chi-Sheng Hung Yi-Lwun Ho Yi-Yao Chang Vin-Cent Wu Xue-Ming Wu Jen-Kuang Lee Shih-Chieh Chueh Yen-Hung Lin Yuan-Shian Changh Shao-Yu Yang Ya-Hui Hu Ming-Jai Sui Ming-Fong Chen Kwan-Dun Wu |
| author_sort | Chi-Sheng Hung |
| collection | DOAJ |
| description | Objective. Primary aldosteronism (PA) is associated with inappropriate left ventricular hypertrophy (LVH) in relation to a given gender and body size. There is no ideal parameter to predict the presence of LVH or inappropriate LVH in patients with PA. We investigate the performance of 24-hour urinary aldosterone level, plasma renin activity and aldosterone-to-renin ratio on this task. Methods. We performed echocardiography in 106 patients with PA and 31 subjects with essential hypertension (EH) in a tertiary teaching hospital. Plasma renin activity, aldosterone concentration, and 24-hour urinary aldosterone level were measured. Results. Only 24-hour urinary aldosterone was correlated with left ventricular mass index (LVMI) and excess LVMI among these parameters. The multivariate analysis revealed the urinary aldosterone level as an independent predictor for LVMI and excess LVMI. Analyzing the ability of urinary aldosterone, plasma aldosterone concentration, and plasma aldosterone-to-renin ratio to identify the presence of LVH (ROC AUC = 0.701, 0.568, 0.656, resp.) and the presence of inappropriate LV mass index (defined as measured LVMI in predicting LVMI ratio >135%) (ROC area under curve = 0.61, 0.43, 0.493, resp.) revealed the better performance of 24-hour urinary aldosterone. Conclusions. In conclusion, 24-hour urinary aldosterone level performed better to predict the presence of LVH and inappropriate LVMI in patients with PA. |
| format | Article |
| id | doaj-art-9a22afcb98704d61849599b7ae2b1fc2 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-9a22afcb98704d61849599b7ae2b1fc22025-02-03T01:12:25ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/294594294594Twenty-Four-Hour Urinary Aldosterone Predicts Inappropriate Left Ventricular Mass Index in Patients with Primary AldosteronismChi-Sheng Hung0Yi-Lwun Ho1Yi-Yao Chang2Vin-Cent Wu3Xue-Ming Wu4Jen-Kuang Lee5Shih-Chieh Chueh6Yen-Hung Lin7Yuan-Shian Changh8Shao-Yu Yang9Ya-Hui Hu10Ming-Jai Sui11Ming-Fong Chen12Kwan-Dun Wu13Telehealth Center, National Taiwan University Hospital, No. 7 Chung-Shan S. Road, Taipei 100, TaiwanTelehealth Center, National Taiwan University Hospital, No. 7 Chung-Shan S. Road, Taipei 100, TaiwanDepartment of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, No. 7 Chung-Shan S. Road, Taipei 100, TaiwanDepartment of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, No. 7 Chung-Shan S. Road, Taipei 100, TaiwanDepartment of Internal Medicine, Taoyuan General Hospital, Taoyuan 330, TaiwanDepartment of Laboratory Medicine, Far Eastern Memorial Hospital, New Taipei City 220, TaiwanDepartment of Urology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100, TaiwanDepartment of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, No. 7 Chung-Shan S. Road, Taipei 100, TaiwanDepartment of Internal Medicine, Postal Hospital, Taipei 100, TaiwanDepartment of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, No. 7 Chung-Shan S. Road, Taipei 100, TaiwanInternal Medicine, Buddhist Tzu Chi General Hospital, New Taipei City 231, TaiwanInstitute of Pharmacology, National Taiwan University Medical College, Taipei 100, TaiwanDepartment of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, No. 7 Chung-Shan S. Road, Taipei 100, TaiwanDepartment of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, No. 7 Chung-Shan S. Road, Taipei 100, TaiwanObjective. Primary aldosteronism (PA) is associated with inappropriate left ventricular hypertrophy (LVH) in relation to a given gender and body size. There is no ideal parameter to predict the presence of LVH or inappropriate LVH in patients with PA. We investigate the performance of 24-hour urinary aldosterone level, plasma renin activity and aldosterone-to-renin ratio on this task. Methods. We performed echocardiography in 106 patients with PA and 31 subjects with essential hypertension (EH) in a tertiary teaching hospital. Plasma renin activity, aldosterone concentration, and 24-hour urinary aldosterone level were measured. Results. Only 24-hour urinary aldosterone was correlated with left ventricular mass index (LVMI) and excess LVMI among these parameters. The multivariate analysis revealed the urinary aldosterone level as an independent predictor for LVMI and excess LVMI. Analyzing the ability of urinary aldosterone, plasma aldosterone concentration, and plasma aldosterone-to-renin ratio to identify the presence of LVH (ROC AUC = 0.701, 0.568, 0.656, resp.) and the presence of inappropriate LV mass index (defined as measured LVMI in predicting LVMI ratio >135%) (ROC area under curve = 0.61, 0.43, 0.493, resp.) revealed the better performance of 24-hour urinary aldosterone. Conclusions. In conclusion, 24-hour urinary aldosterone level performed better to predict the presence of LVH and inappropriate LVMI in patients with PA.http://dx.doi.org/10.1155/2013/294594 |
| spellingShingle | Chi-Sheng Hung Yi-Lwun Ho Yi-Yao Chang Vin-Cent Wu Xue-Ming Wu Jen-Kuang Lee Shih-Chieh Chueh Yen-Hung Lin Yuan-Shian Changh Shao-Yu Yang Ya-Hui Hu Ming-Jai Sui Ming-Fong Chen Kwan-Dun Wu Twenty-Four-Hour Urinary Aldosterone Predicts Inappropriate Left Ventricular Mass Index in Patients with Primary Aldosteronism The Scientific World Journal |
| title | Twenty-Four-Hour Urinary Aldosterone Predicts Inappropriate Left Ventricular Mass Index in Patients with Primary Aldosteronism |
| title_full | Twenty-Four-Hour Urinary Aldosterone Predicts Inappropriate Left Ventricular Mass Index in Patients with Primary Aldosteronism |
| title_fullStr | Twenty-Four-Hour Urinary Aldosterone Predicts Inappropriate Left Ventricular Mass Index in Patients with Primary Aldosteronism |
| title_full_unstemmed | Twenty-Four-Hour Urinary Aldosterone Predicts Inappropriate Left Ventricular Mass Index in Patients with Primary Aldosteronism |
| title_short | Twenty-Four-Hour Urinary Aldosterone Predicts Inappropriate Left Ventricular Mass Index in Patients with Primary Aldosteronism |
| title_sort | twenty four hour urinary aldosterone predicts inappropriate left ventricular mass index in patients with primary aldosteronism |
| url | http://dx.doi.org/10.1155/2013/294594 |
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