Melatonin in Hypoxic-Ischemic Brain Injury in Term and Preterm Babies
Melatonin may serve as a potential therapeutic free radical scavenger and broad-spectrum antioxidant. It shows neuroprotective properties against hypoxic-ischemic brain injury in animal models. The authors review the studies focusing on the neuroprotective potential of melatonin and its possibility...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2019/9626715 |
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| _version_ | 1832547522894102528 |
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| author | Justyna Paprocka Marek Kijonka Beata Rzepka Maria Sokół |
| author_facet | Justyna Paprocka Marek Kijonka Beata Rzepka Maria Sokół |
| author_sort | Justyna Paprocka |
| collection | DOAJ |
| description | Melatonin may serve as a potential therapeutic free radical scavenger and broad-spectrum antioxidant. It shows neuroprotective properties against hypoxic-ischemic brain injury in animal models. The authors review the studies focusing on the neuroprotective potential of melatonin and its possibility of treatment after perinatal asphyxia. Melatonin efficacy, low toxicity, and ability to readily cross through the blood-brain barrier make it a promising molecule. A very interesting thing is the difference between the half-life of melatonin in preterm neonates (15 hours) and adults (45-60 minutes). Probably, the use of synergic strategies—hypothermia coupled with melatonin treatment—may be promising in improving antioxidant action. The authors discuss and try to summarize the evidence surrounding the use of melatonin in hypoxic-ischemic events in term and preterm babies. |
| format | Article |
| id | doaj-art-9a16d7442c084a12b7d3fb6ab1137307 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-9a16d7442c084a12b7d3fb6ab11373072025-02-03T06:44:26ZengWileyInternational Journal of Endocrinology1687-83371687-83452019-01-01201910.1155/2019/96267159626715Melatonin in Hypoxic-Ischemic Brain Injury in Term and Preterm BabiesJustyna Paprocka0Marek Kijonka1Beata Rzepka2Maria Sokół3Department of Pediatric Neurology, School of Medicine in Katowice, Medical University of Silesia, Katowice, PolandDepartment of Medical Physics, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology Gliwice Branch, PolandStudents’ Scientific Society, Department Pediatric Neurology, School of Medicine in Katowice, Medical University of Silesia, Katowice, PolandDepartment of Medical Physics, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology Gliwice Branch, PolandMelatonin may serve as a potential therapeutic free radical scavenger and broad-spectrum antioxidant. It shows neuroprotective properties against hypoxic-ischemic brain injury in animal models. The authors review the studies focusing on the neuroprotective potential of melatonin and its possibility of treatment after perinatal asphyxia. Melatonin efficacy, low toxicity, and ability to readily cross through the blood-brain barrier make it a promising molecule. A very interesting thing is the difference between the half-life of melatonin in preterm neonates (15 hours) and adults (45-60 minutes). Probably, the use of synergic strategies—hypothermia coupled with melatonin treatment—may be promising in improving antioxidant action. The authors discuss and try to summarize the evidence surrounding the use of melatonin in hypoxic-ischemic events in term and preterm babies.http://dx.doi.org/10.1155/2019/9626715 |
| spellingShingle | Justyna Paprocka Marek Kijonka Beata Rzepka Maria Sokół Melatonin in Hypoxic-Ischemic Brain Injury in Term and Preterm Babies International Journal of Endocrinology |
| title | Melatonin in Hypoxic-Ischemic Brain Injury in Term and Preterm Babies |
| title_full | Melatonin in Hypoxic-Ischemic Brain Injury in Term and Preterm Babies |
| title_fullStr | Melatonin in Hypoxic-Ischemic Brain Injury in Term and Preterm Babies |
| title_full_unstemmed | Melatonin in Hypoxic-Ischemic Brain Injury in Term and Preterm Babies |
| title_short | Melatonin in Hypoxic-Ischemic Brain Injury in Term and Preterm Babies |
| title_sort | melatonin in hypoxic ischemic brain injury in term and preterm babies |
| url | http://dx.doi.org/10.1155/2019/9626715 |
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