Gut Microbiota and Their Metabolites: The Hidden Driver of Diabetic Nephropathy? Unveiling Gut Microbe's Role in DN
ABSTRACT Background Diabetic nephropathy (DN) is a severe microvascular complication of diabetes with a complex pathogenesis. Methods Recent studies were reviewed to explore the role of gut microbiota and its metabolites in DN development. Results Dysbiosis of gut bacteria contributes to pathologica...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-04-01
|
| Series: | Journal of Diabetes |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/1753-0407.70068 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850139813113495552 |
|---|---|
| author | Jinzhou Liu Min Guo Xiaobin Yuan Xiao Fan Jin Wang Xiangying Jiao |
| author_facet | Jinzhou Liu Min Guo Xiaobin Yuan Xiao Fan Jin Wang Xiangying Jiao |
| author_sort | Jinzhou Liu |
| collection | DOAJ |
| description | ABSTRACT Background Diabetic nephropathy (DN) is a severe microvascular complication of diabetes with a complex pathogenesis. Methods Recent studies were reviewed to explore the role of gut microbiota and its metabolites in DN development. Results Dysbiosis of gut bacteria contributes to pathological changes such as glomerular sclerosis and renal tubule injury. Microbial metabolites are involved in DN through immune and inflammatory pathways. Conclusions Understanding the relationship between gut microbiota, its metabolites, and DN may offer potential implications for DN diagnosis, prevention, and treatment. Translating this knowledge into clinical practice presents challenges and opportunities. |
| format | Article |
| id | doaj-art-9a142e5a6a4d4e1992dbb8a3e30ddcb3 |
| institution | OA Journals |
| issn | 1753-0393 1753-0407 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes |
| spelling | doaj-art-9a142e5a6a4d4e1992dbb8a3e30ddcb32025-08-20T02:30:06ZengWileyJournal of Diabetes1753-03931753-04072025-04-01174n/an/a10.1111/1753-0407.70068Gut Microbiota and Their Metabolites: The Hidden Driver of Diabetic Nephropathy? Unveiling Gut Microbe's Role in DNJinzhou Liu0Min Guo1Xiaobin Yuan2Xiao Fan3Jin Wang4Xiangying Jiao5Department of Physiology The Key Laboratory of Physiology of Shanxi Province, the Key Laboratory of Cellular Physiology of Ministry of Education, Shanxi Medical University Taiyuan ChinaDepartment of Physiology The Key Laboratory of Physiology of Shanxi Province, the Key Laboratory of Cellular Physiology of Ministry of Education, Shanxi Medical University Taiyuan ChinaDepartment of Urology First Hospital of Shanxi Medical University Taiyuan ChinaDepartment of Urology First Hospital of Shanxi Medical University Taiyuan ChinaDepartment of Physiology The Key Laboratory of Physiology of Shanxi Province, the Key Laboratory of Cellular Physiology of Ministry of Education, Shanxi Medical University Taiyuan ChinaDepartment of Physiology The Key Laboratory of Physiology of Shanxi Province, the Key Laboratory of Cellular Physiology of Ministry of Education, Shanxi Medical University Taiyuan ChinaABSTRACT Background Diabetic nephropathy (DN) is a severe microvascular complication of diabetes with a complex pathogenesis. Methods Recent studies were reviewed to explore the role of gut microbiota and its metabolites in DN development. Results Dysbiosis of gut bacteria contributes to pathological changes such as glomerular sclerosis and renal tubule injury. Microbial metabolites are involved in DN through immune and inflammatory pathways. Conclusions Understanding the relationship between gut microbiota, its metabolites, and DN may offer potential implications for DN diagnosis, prevention, and treatment. Translating this knowledge into clinical practice presents challenges and opportunities.https://doi.org/10.1111/1753-0407.70068diabetic nephropathygut microbiotagut–kidney axismicrobial metabolitesnovel biomarkers |
| spellingShingle | Jinzhou Liu Min Guo Xiaobin Yuan Xiao Fan Jin Wang Xiangying Jiao Gut Microbiota and Their Metabolites: The Hidden Driver of Diabetic Nephropathy? Unveiling Gut Microbe's Role in DN Journal of Diabetes diabetic nephropathy gut microbiota gut–kidney axis microbial metabolites novel biomarkers |
| title | Gut Microbiota and Their Metabolites: The Hidden Driver of Diabetic Nephropathy? Unveiling Gut Microbe's Role in DN |
| title_full | Gut Microbiota and Their Metabolites: The Hidden Driver of Diabetic Nephropathy? Unveiling Gut Microbe's Role in DN |
| title_fullStr | Gut Microbiota and Their Metabolites: The Hidden Driver of Diabetic Nephropathy? Unveiling Gut Microbe's Role in DN |
| title_full_unstemmed | Gut Microbiota and Their Metabolites: The Hidden Driver of Diabetic Nephropathy? Unveiling Gut Microbe's Role in DN |
| title_short | Gut Microbiota and Their Metabolites: The Hidden Driver of Diabetic Nephropathy? Unveiling Gut Microbe's Role in DN |
| title_sort | gut microbiota and their metabolites the hidden driver of diabetic nephropathy unveiling gut microbe s role in dn |
| topic | diabetic nephropathy gut microbiota gut–kidney axis microbial metabolites novel biomarkers |
| url | https://doi.org/10.1111/1753-0407.70068 |
| work_keys_str_mv | AT jinzhouliu gutmicrobiotaandtheirmetabolitesthehiddendriverofdiabeticnephropathyunveilinggutmicrobesroleindn AT minguo gutmicrobiotaandtheirmetabolitesthehiddendriverofdiabeticnephropathyunveilinggutmicrobesroleindn AT xiaobinyuan gutmicrobiotaandtheirmetabolitesthehiddendriverofdiabeticnephropathyunveilinggutmicrobesroleindn AT xiaofan gutmicrobiotaandtheirmetabolitesthehiddendriverofdiabeticnephropathyunveilinggutmicrobesroleindn AT jinwang gutmicrobiotaandtheirmetabolitesthehiddendriverofdiabeticnephropathyunveilinggutmicrobesroleindn AT xiangyingjiao gutmicrobiotaandtheirmetabolitesthehiddendriverofdiabeticnephropathyunveilinggutmicrobesroleindn |