Serum Hepcidin Level as a Marker of Iron Status in Children with Cystic Fibrosis
Introduction. Iron deficiency is common in patients with cystic fibrosis. Conventional iron status markers are often abnormal in patients with CF, reflecting inflammation and/or infection, rather than actual iron stores. The aim was to evaluate serum hepcidin levels against selected iron status mark...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2018/3040346 |
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| author | Monika Kałużna-Czyż Urszula Grzybowska-Chlebowczyk Halina Woś Sabina Więcek |
| author_facet | Monika Kałużna-Czyż Urszula Grzybowska-Chlebowczyk Halina Woś Sabina Więcek |
| author_sort | Monika Kałużna-Czyż |
| collection | DOAJ |
| description | Introduction. Iron deficiency is common in patients with cystic fibrosis. Conventional iron status markers are often abnormal in patients with CF, reflecting inflammation and/or infection, rather than actual iron stores. The aim was to evaluate serum hepcidin levels against selected iron status markers, assuming that hepcidin may be a more sensitive indicator of iron management in patients with active inflammation, such as those with CF. Material and Methods. 46 children with cystic fibrosis and 31 healthy controls were enrolled. Hepcidin concentration was evaluated, along with the following other blood assays: full blood count, Fe, ferritin, transferrin, TIBC, liver markers, and CRP. Results. Higher ferritin and CRP levels as well as lower TIBC levels significantly predicted hepcidin levels in the study group, control group, and the entire sample. There was no significant difference in hepcidin levels between the patients and controls. Children with exacerbations had significantly higher hepcidin levels than those with stable disease. These findings support the serum hepcidin level as useful in assessing iron status in children with cystic fibrosis. It may also be useful in early detection and monitoring of treatment of exacerbations. |
| format | Article |
| id | doaj-art-9a0eedc3006e40b5850f42d851d2e250 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-9a0eedc3006e40b5850f42d851d2e2502025-02-03T01:02:31ZengWileyMediators of Inflammation0962-93511466-18612018-01-01201810.1155/2018/30403463040346Serum Hepcidin Level as a Marker of Iron Status in Children with Cystic FibrosisMonika Kałużna-Czyż0Urszula Grzybowska-Chlebowczyk1Halina Woś2Sabina Więcek3Department of Paediatrics, School of Medicine in Katowice, Medical University of Silesia, Katowice, PolandDepartment of Paediatrics, School of Medicine in Katowice, Medical University of Silesia, Katowice, PolandDepartment of Nursing and Emergency Medicine, Faculty of Health Sciences, University of Bielsko-Biała, Bielsko-Biała, PolandDepartment of Paediatrics, School of Medicine in Katowice, Medical University of Silesia, Katowice, PolandIntroduction. Iron deficiency is common in patients with cystic fibrosis. Conventional iron status markers are often abnormal in patients with CF, reflecting inflammation and/or infection, rather than actual iron stores. The aim was to evaluate serum hepcidin levels against selected iron status markers, assuming that hepcidin may be a more sensitive indicator of iron management in patients with active inflammation, such as those with CF. Material and Methods. 46 children with cystic fibrosis and 31 healthy controls were enrolled. Hepcidin concentration was evaluated, along with the following other blood assays: full blood count, Fe, ferritin, transferrin, TIBC, liver markers, and CRP. Results. Higher ferritin and CRP levels as well as lower TIBC levels significantly predicted hepcidin levels in the study group, control group, and the entire sample. There was no significant difference in hepcidin levels between the patients and controls. Children with exacerbations had significantly higher hepcidin levels than those with stable disease. These findings support the serum hepcidin level as useful in assessing iron status in children with cystic fibrosis. It may also be useful in early detection and monitoring of treatment of exacerbations.http://dx.doi.org/10.1155/2018/3040346 |
| spellingShingle | Monika Kałużna-Czyż Urszula Grzybowska-Chlebowczyk Halina Woś Sabina Więcek Serum Hepcidin Level as a Marker of Iron Status in Children with Cystic Fibrosis Mediators of Inflammation |
| title | Serum Hepcidin Level as a Marker of Iron Status in Children with Cystic Fibrosis |
| title_full | Serum Hepcidin Level as a Marker of Iron Status in Children with Cystic Fibrosis |
| title_fullStr | Serum Hepcidin Level as a Marker of Iron Status in Children with Cystic Fibrosis |
| title_full_unstemmed | Serum Hepcidin Level as a Marker of Iron Status in Children with Cystic Fibrosis |
| title_short | Serum Hepcidin Level as a Marker of Iron Status in Children with Cystic Fibrosis |
| title_sort | serum hepcidin level as a marker of iron status in children with cystic fibrosis |
| url | http://dx.doi.org/10.1155/2018/3040346 |
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