Assessment of Acute and Chronic Pharmacological Effects on Energy Expenditure and Macronutrient Oxidation in Humans: Responses to Ephedrine
Evidence of active brown adipose tissue in human adults suggests that this may become a pharmacological target to induce negative energy balance. We have explored whole-body indirect calorimetry to detect the metabolic effects of thermogenic drugs through administration of ephedrine hydrochloride an...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2011/210484 |
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| _version_ | 1832545728980844544 |
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| author | Antonella Napolitano Peter R. Murgatroyd Nick Finer Elizabeth K. Hussey Robert Dobbins Steve O'Rahilly Derek J. R. Nunez |
| author_facet | Antonella Napolitano Peter R. Murgatroyd Nick Finer Elizabeth K. Hussey Robert Dobbins Steve O'Rahilly Derek J. R. Nunez |
| author_sort | Antonella Napolitano |
| collection | DOAJ |
| description | Evidence of active brown adipose tissue in human adults suggests that this may become a pharmacological target to induce negative energy balance. We have explored whole-body indirect calorimetry to detect the metabolic effects of thermogenic drugs through administration of ephedrine hydrochloride and have assessed ephedrine's merits as a comparator compound in the evaluation of novel thermogenic agents. Volunteers randomly given ephedrine hydrochloride 15 mg QID (n=8) or placebo (n=6) were studied at baseline and after 1-2 and 14-15 days of treatment. We demonstrate that overnight or 23-hour, 2% energy expenditure (EE) and 5% fat (FO) or CHO oxidation effects are detectable both acutely and over 14 days. Compared to placebo, ephedrine increased EE and FO rates overnight (EE 63 kJ day 2, EE 105 kJ, FO 190 kJ, day 14), but not over 23 h. We conclude that modest energy expenditure and fat oxidation responses to pharmacological interventions can be confidently detected by calorimetry in small groups. Ephedrine should provide reliable data against which to compare novel thermogenic compounds. |
| format | Article |
| id | doaj-art-9a0804060bcc42fcb948eceed70c9f45 |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-9a0804060bcc42fcb948eceed70c9f452025-02-03T07:24:59ZengWileyJournal of Obesity2090-07082090-07162011-01-01201110.1155/2011/210484210484Assessment of Acute and Chronic Pharmacological Effects on Energy Expenditure and Macronutrient Oxidation in Humans: Responses to EphedrineAntonella Napolitano0Peter R. Murgatroyd1Nick Finer2Elizabeth K. Hussey3Robert Dobbins4Steve O'Rahilly5Derek J. R. Nunez6Clinical Unit in Cambridge, GlaxoSmithKline, ACCI, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 2QQ, UKWellcome Trust Clinical Research Facility, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 2QQ, UKWellcome Trust Clinical Research Facility, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 2QQ, UKMetabolic Pathways Center of Excellence for Drug Discovery, GlaxoSmithKline Research Triangle Park, NC 27709, USAMetabolic Pathways Center of Excellence for Drug Discovery, GlaxoSmithKline Research Triangle Park, NC 27709, USAWellcome Trust Clinical Research Facility, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 2QQ, UKMetabolic Pathways Center of Excellence for Drug Discovery, GlaxoSmithKline Research Triangle Park, NC 27709, USAEvidence of active brown adipose tissue in human adults suggests that this may become a pharmacological target to induce negative energy balance. We have explored whole-body indirect calorimetry to detect the metabolic effects of thermogenic drugs through administration of ephedrine hydrochloride and have assessed ephedrine's merits as a comparator compound in the evaluation of novel thermogenic agents. Volunteers randomly given ephedrine hydrochloride 15 mg QID (n=8) or placebo (n=6) were studied at baseline and after 1-2 and 14-15 days of treatment. We demonstrate that overnight or 23-hour, 2% energy expenditure (EE) and 5% fat (FO) or CHO oxidation effects are detectable both acutely and over 14 days. Compared to placebo, ephedrine increased EE and FO rates overnight (EE 63 kJ day 2, EE 105 kJ, FO 190 kJ, day 14), but not over 23 h. We conclude that modest energy expenditure and fat oxidation responses to pharmacological interventions can be confidently detected by calorimetry in small groups. Ephedrine should provide reliable data against which to compare novel thermogenic compounds.http://dx.doi.org/10.1155/2011/210484 |
| spellingShingle | Antonella Napolitano Peter R. Murgatroyd Nick Finer Elizabeth K. Hussey Robert Dobbins Steve O'Rahilly Derek J. R. Nunez Assessment of Acute and Chronic Pharmacological Effects on Energy Expenditure and Macronutrient Oxidation in Humans: Responses to Ephedrine Journal of Obesity |
| title | Assessment of Acute and Chronic Pharmacological Effects on Energy Expenditure and Macronutrient Oxidation in Humans: Responses to Ephedrine |
| title_full | Assessment of Acute and Chronic Pharmacological Effects on Energy Expenditure and Macronutrient Oxidation in Humans: Responses to Ephedrine |
| title_fullStr | Assessment of Acute and Chronic Pharmacological Effects on Energy Expenditure and Macronutrient Oxidation in Humans: Responses to Ephedrine |
| title_full_unstemmed | Assessment of Acute and Chronic Pharmacological Effects on Energy Expenditure and Macronutrient Oxidation in Humans: Responses to Ephedrine |
| title_short | Assessment of Acute and Chronic Pharmacological Effects on Energy Expenditure and Macronutrient Oxidation in Humans: Responses to Ephedrine |
| title_sort | assessment of acute and chronic pharmacological effects on energy expenditure and macronutrient oxidation in humans responses to ephedrine |
| url | http://dx.doi.org/10.1155/2011/210484 |
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