The role of the CLL-1 protein in disease monitoring in patients diagnosed with acute myeloid leukaemia and myelodysplastic syndrome
The normal subpopulation of CD34+CD38 – haematopoietic stem cells does not express CLL-1; therefore, the assessment of the expression of this protein can be used for the diagnosis of minimal residual disease. The aim of this study was to evaluate, using multi-colour flow cytometry, the level of CLL-...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2024-10-01
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| Series: | Polish Journal of Pathology |
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| Online Access: | https://www.termedia.pl/The-role-of-the-CLL-1-protein-in-disease-monitoring-in-patients-diagnosed-with-acute-myeloid-leukaemia-and-myelodysplastic-syndrome,55,54823,1,1.html |
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| author | Ewa Dobak Sylwia Romana Jankowska-Szabłowska Renata Guzicka-Kazimierczak Paulina Poter Elżbieta Urasińska Katarzyna Karpińska-Łukaszewicz |
| author_facet | Ewa Dobak Sylwia Romana Jankowska-Szabłowska Renata Guzicka-Kazimierczak Paulina Poter Elżbieta Urasińska Katarzyna Karpińska-Łukaszewicz |
| author_sort | Ewa Dobak |
| collection | DOAJ |
| description | The normal subpopulation of CD34+CD38 – haematopoietic stem cells does not express CLL-1; therefore, the assessment of the expression of this protein can be used for the diagnosis of minimal residual disease. The aim of this study was to evaluate, using multi-colour flow cytometry, the level of CLL-1 protein expression on CD34+CD38- myeloid niche cells in acute myeloid leukaemia (AML) and myelodysplastic syndromepatients at the time of diagnosis and during disease monitoring on the example of 3 practical cases. The following conclusion was drawn: CD34+CD38-CLL-1+ cells in AML patients may serve as a biomarker to predict disease aggressiveness. |
| format | Article |
| id | doaj-art-9a00d6af06604ee7bc7a13ed22030bc0 |
| institution | Kabale University |
| issn | 1233-9687 2084-9869 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Polish Journal of Pathology |
| spelling | doaj-art-9a00d6af06604ee7bc7a13ed22030bc02025-01-27T11:36:07ZengTermedia Publishing HousePolish Journal of Pathology1233-96872084-98692024-10-0175318219110.5114/pjp.2024.14322854823The role of the CLL-1 protein in disease monitoring in patients diagnosed with acute myeloid leukaemia and myelodysplastic syndromeEwa DobakSylwia Romana Jankowska-SzabłowskaRenata Guzicka-KazimierczakPaulina PoterElżbieta UrasińskaKatarzyna Karpińska-ŁukaszewiczThe normal subpopulation of CD34+CD38 – haematopoietic stem cells does not express CLL-1; therefore, the assessment of the expression of this protein can be used for the diagnosis of minimal residual disease. The aim of this study was to evaluate, using multi-colour flow cytometry, the level of CLL-1 protein expression on CD34+CD38- myeloid niche cells in acute myeloid leukaemia (AML) and myelodysplastic syndromepatients at the time of diagnosis and during disease monitoring on the example of 3 practical cases. The following conclusion was drawn: CD34+CD38-CLL-1+ cells in AML patients may serve as a biomarker to predict disease aggressiveness.https://www.termedia.pl/The-role-of-the-CLL-1-protein-in-disease-monitoring-in-patients-diagnosed-with-acute-myeloid-leukaemia-and-myelodysplastic-syndrome,55,54823,1,1.htmlaml cll-1 mds multi-colour flow cytometry. |
| spellingShingle | Ewa Dobak Sylwia Romana Jankowska-Szabłowska Renata Guzicka-Kazimierczak Paulina Poter Elżbieta Urasińska Katarzyna Karpińska-Łukaszewicz The role of the CLL-1 protein in disease monitoring in patients diagnosed with acute myeloid leukaemia and myelodysplastic syndrome Polish Journal of Pathology aml cll-1 mds multi-colour flow cytometry. |
| title | The role of the CLL-1 protein in disease monitoring in patients diagnosed with acute myeloid leukaemia and myelodysplastic syndrome |
| title_full | The role of the CLL-1 protein in disease monitoring in patients diagnosed with acute myeloid leukaemia and myelodysplastic syndrome |
| title_fullStr | The role of the CLL-1 protein in disease monitoring in patients diagnosed with acute myeloid leukaemia and myelodysplastic syndrome |
| title_full_unstemmed | The role of the CLL-1 protein in disease monitoring in patients diagnosed with acute myeloid leukaemia and myelodysplastic syndrome |
| title_short | The role of the CLL-1 protein in disease monitoring in patients diagnosed with acute myeloid leukaemia and myelodysplastic syndrome |
| title_sort | the role of the cll 1 protein in disease monitoring in patients diagnosed with acute myeloid leukaemia and myelodysplastic syndrome |
| topic | aml cll-1 mds multi-colour flow cytometry. |
| url | https://www.termedia.pl/The-role-of-the-CLL-1-protein-in-disease-monitoring-in-patients-diagnosed-with-acute-myeloid-leukaemia-and-myelodysplastic-syndrome,55,54823,1,1.html |
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