A Rare Case of Paraneoplastic Syndrome Presented with Severe Gastroparesis due to Ganglional Loss
Paraneoplastic syndromes are rare initial manifestations of a neoplastic disorder that may precede the actual detection of an overt cancer. These syndromes can generally involve any organic system of the human body with gastroparesis being the commonest manifestation of the paraneoplastic involvemen...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/894837 |
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| author | Konstantinos N. Argyriou Martin Peters Javaid Ishtiaq Santosh Enaganti |
| author_facet | Konstantinos N. Argyriou Martin Peters Javaid Ishtiaq Santosh Enaganti |
| author_sort | Konstantinos N. Argyriou |
| collection | DOAJ |
| description | Paraneoplastic syndromes are rare initial manifestations of a neoplastic disorder that may precede the actual detection of an overt cancer. These syndromes can generally involve any organic system of the human body with gastroparesis being the commonest manifestation of the paraneoplastic involvement of the neuronal bodies of the gastrointestinal tract in cancer patients. Gastroparesis is the result of an autoimmune destruction of the nerve plexus of the stomach that causes nonspecific gastrointestinal symptoms such as intractable vomiting and abdominal discomfort that interfere with patients' quality of life and are often ascribed to psychological factors. Thus, if not suspected, it easily evades the diagnostic thought especially in those cases where the diagnostic work up has not detected any apparent cause. Consequently, it should always be considered in patients with diagnosed or suspected cancer who complain of unexplained gastrointestinal symptoms. In our report, so as to increase the clinical awareness of this rare clinical entity, we present the case of a 70-year-old Caucasian female who presented in our hospital with severe gastroparesis that was later proven to be associated with an overt small cell lung cancer (SCLC) and we discuss the existing knowledge of the pathophysiology, diagnosis, and management of this disorder. |
| format | Article |
| id | doaj-art-99fdb1c2e3584b729c7fd5d2a1137257 |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-99fdb1c2e3584b729c7fd5d2a11372572025-02-03T01:03:01ZengWileyCase Reports in Medicine1687-96271687-96352012-01-01201210.1155/2012/894837894837A Rare Case of Paraneoplastic Syndrome Presented with Severe Gastroparesis due to Ganglional LossKonstantinos N. Argyriou0Martin Peters1Javaid Ishtiaq2Santosh Enaganti3Gastroenterology Department, Diana, Princess of Wales Hospital, South Humberside DN33 2BA, UKHistopathology Department, Diana, Princess of Wales Hospital, South Humberside DN33 2BA, UKGastroenterology Department, Diana, Princess of Wales Hospital, South Humberside DN33 2BA, UKGastroenterology Department, Diana, Princess of Wales Hospital, South Humberside DN33 2BA, UKParaneoplastic syndromes are rare initial manifestations of a neoplastic disorder that may precede the actual detection of an overt cancer. These syndromes can generally involve any organic system of the human body with gastroparesis being the commonest manifestation of the paraneoplastic involvement of the neuronal bodies of the gastrointestinal tract in cancer patients. Gastroparesis is the result of an autoimmune destruction of the nerve plexus of the stomach that causes nonspecific gastrointestinal symptoms such as intractable vomiting and abdominal discomfort that interfere with patients' quality of life and are often ascribed to psychological factors. Thus, if not suspected, it easily evades the diagnostic thought especially in those cases where the diagnostic work up has not detected any apparent cause. Consequently, it should always be considered in patients with diagnosed or suspected cancer who complain of unexplained gastrointestinal symptoms. In our report, so as to increase the clinical awareness of this rare clinical entity, we present the case of a 70-year-old Caucasian female who presented in our hospital with severe gastroparesis that was later proven to be associated with an overt small cell lung cancer (SCLC) and we discuss the existing knowledge of the pathophysiology, diagnosis, and management of this disorder.http://dx.doi.org/10.1155/2012/894837 |
| spellingShingle | Konstantinos N. Argyriou Martin Peters Javaid Ishtiaq Santosh Enaganti A Rare Case of Paraneoplastic Syndrome Presented with Severe Gastroparesis due to Ganglional Loss Case Reports in Medicine |
| title | A Rare Case of Paraneoplastic Syndrome Presented with Severe Gastroparesis due to Ganglional Loss |
| title_full | A Rare Case of Paraneoplastic Syndrome Presented with Severe Gastroparesis due to Ganglional Loss |
| title_fullStr | A Rare Case of Paraneoplastic Syndrome Presented with Severe Gastroparesis due to Ganglional Loss |
| title_full_unstemmed | A Rare Case of Paraneoplastic Syndrome Presented with Severe Gastroparesis due to Ganglional Loss |
| title_short | A Rare Case of Paraneoplastic Syndrome Presented with Severe Gastroparesis due to Ganglional Loss |
| title_sort | rare case of paraneoplastic syndrome presented with severe gastroparesis due to ganglional loss |
| url | http://dx.doi.org/10.1155/2012/894837 |
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