Appetite Suppression and Antiobesity Effect of a Botanical Composition Composed of Morus alba, Yerba mate, and Magnolia officinalis
Background. Obesity and its comorbidities continue to challenge the world at an alarming rate. Although the long term solution lies on lifestyle changes in the form of dieting and exercising, drug, medical food, or dietary supplement interventions are required for those who are already obese. Here w...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2016/4670818 |
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| author | Mesfin Yimam Ping Jiao Mei Hong Lidia Brownell Young-Chul Lee Eu-Jin Hyun Hyun-Jin Kim Tae-Woo Kim Jeong-Bum Nam Mi-Ran Kim Qi Jia |
| author_facet | Mesfin Yimam Ping Jiao Mei Hong Lidia Brownell Young-Chul Lee Eu-Jin Hyun Hyun-Jin Kim Tae-Woo Kim Jeong-Bum Nam Mi-Ran Kim Qi Jia |
| author_sort | Mesfin Yimam |
| collection | DOAJ |
| description | Background. Obesity and its comorbidities continue to challenge the world at an alarming rate. Although the long term solution lies on lifestyle changes in the form of dieting and exercising, drug, medical food, or dietary supplement interventions are required for those who are already obese. Here we describe a standardized blend composed of extracts from three medicinal plants: Morus alba, Yerba mate, and Magnolia officinalis for appetite suppression and metabolic disorders management. Method. Extracts were standardized to yield a composition designated as UP601. Appetite suppression activity was tested in acute feed intake rat model. Efficacy was evaluated in C57BL/6J mouse models treated with oral doses of 1.3 g/kg/day for 7 weeks. Orlistat at 40 mg/kg/day was used as a positive control. Body compositions of mice were assessed using a dual energy X-ray absorptiometry (DEXA). ELISA was done for insulin, leptin, and ghrelin level quantitation. Nonalcoholic steatohepatitis (NASH) scoring was conducted. Results. Marked acute hypophagia with 81.8, 75.3, 43.9, and 30.9% reductions in food intake at 2, 4, 6, and 24 hours were observed for UP601. Decreases in body weight gain (21.5% compared to the HFD at weeks 7 and 8.2% compared to baseline) and calorie intake (40.5% for the first week) were observed. 75.9% and 46.8% reductions in insulin and leptin, respectively, 4.2-fold increase in ghrelin level, and reductions of 18.6% in cholesterol and 59% in low-density lipoprotein were documented. A percentage body fat of 18.9%, 47.8%, 46.1%, and 30.4% was found for mice treated with normal control, HFD, Orlistat, and UP601, respectively. 59.3% less mesenteric fat pad and improved NASH scores were observed for UP601. Conclusion. UP601, a standardized botanical composition from Morus alba, Yerba mate, and Magnolia officinalis could be used as a natural alternative for appetite suppression, maintaining healthy body weight and metabolism management. |
| format | Article |
| id | doaj-art-99ea9676757b4bec8bef656d1af6eeff |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-99ea9676757b4bec8bef656d1af6eeff2025-02-03T01:31:05ZengWileyJournal of Obesity2090-07082090-07162016-01-01201610.1155/2016/46708184670818Appetite Suppression and Antiobesity Effect of a Botanical Composition Composed of Morus alba, Yerba mate, and Magnolia officinalisMesfin Yimam0Ping Jiao1Mei Hong2Lidia Brownell3Young-Chul Lee4Eu-Jin Hyun5Hyun-Jin Kim6Tae-Woo Kim7Jeong-Bum Nam8Mi-Ran Kim9Qi Jia10Unigen Inc., 3005 1st Avenue Seattle, WA 98121, USAUnigen Inc., 3005 1st Avenue Seattle, WA 98121, USAUnigen Inc., 3005 1st Avenue Seattle, WA 98121, USAUnigen Inc., 3005 1st Avenue Seattle, WA 98121, USAUnigen Inc., No. 450-86, Maebong-Ro, Dongnam-Gu, Cheonan-Si, Chungnam 330-863, Republic of KoreaUnigen Inc., No. 450-86, Maebong-Ro, Dongnam-Gu, Cheonan-Si, Chungnam 330-863, Republic of KoreaUnigen Inc., No. 450-86, Maebong-Ro, Dongnam-Gu, Cheonan-Si, Chungnam 330-863, Republic of KoreaUnigen Inc., No. 450-86, Maebong-Ro, Dongnam-Gu, Cheonan-Si, Chungnam 330-863, Republic of KoreaUnigen Inc., No. 450-86, Maebong-Ro, Dongnam-Gu, Cheonan-Si, Chungnam 330-863, Republic of KoreaUnigen Inc., No. 450-86, Maebong-Ro, Dongnam-Gu, Cheonan-Si, Chungnam 330-863, Republic of KoreaUnigen Inc., 3005 1st Avenue Seattle, WA 98121, USABackground. Obesity and its comorbidities continue to challenge the world at an alarming rate. Although the long term solution lies on lifestyle changes in the form of dieting and exercising, drug, medical food, or dietary supplement interventions are required for those who are already obese. Here we describe a standardized blend composed of extracts from three medicinal plants: Morus alba, Yerba mate, and Magnolia officinalis for appetite suppression and metabolic disorders management. Method. Extracts were standardized to yield a composition designated as UP601. Appetite suppression activity was tested in acute feed intake rat model. Efficacy was evaluated in C57BL/6J mouse models treated with oral doses of 1.3 g/kg/day for 7 weeks. Orlistat at 40 mg/kg/day was used as a positive control. Body compositions of mice were assessed using a dual energy X-ray absorptiometry (DEXA). ELISA was done for insulin, leptin, and ghrelin level quantitation. Nonalcoholic steatohepatitis (NASH) scoring was conducted. Results. Marked acute hypophagia with 81.8, 75.3, 43.9, and 30.9% reductions in food intake at 2, 4, 6, and 24 hours were observed for UP601. Decreases in body weight gain (21.5% compared to the HFD at weeks 7 and 8.2% compared to baseline) and calorie intake (40.5% for the first week) were observed. 75.9% and 46.8% reductions in insulin and leptin, respectively, 4.2-fold increase in ghrelin level, and reductions of 18.6% in cholesterol and 59% in low-density lipoprotein were documented. A percentage body fat of 18.9%, 47.8%, 46.1%, and 30.4% was found for mice treated with normal control, HFD, Orlistat, and UP601, respectively. 59.3% less mesenteric fat pad and improved NASH scores were observed for UP601. Conclusion. UP601, a standardized botanical composition from Morus alba, Yerba mate, and Magnolia officinalis could be used as a natural alternative for appetite suppression, maintaining healthy body weight and metabolism management.http://dx.doi.org/10.1155/2016/4670818 |
| spellingShingle | Mesfin Yimam Ping Jiao Mei Hong Lidia Brownell Young-Chul Lee Eu-Jin Hyun Hyun-Jin Kim Tae-Woo Kim Jeong-Bum Nam Mi-Ran Kim Qi Jia Appetite Suppression and Antiobesity Effect of a Botanical Composition Composed of Morus alba, Yerba mate, and Magnolia officinalis Journal of Obesity |
| title | Appetite Suppression and Antiobesity Effect of a Botanical Composition Composed of Morus alba, Yerba mate, and Magnolia officinalis |
| title_full | Appetite Suppression and Antiobesity Effect of a Botanical Composition Composed of Morus alba, Yerba mate, and Magnolia officinalis |
| title_fullStr | Appetite Suppression and Antiobesity Effect of a Botanical Composition Composed of Morus alba, Yerba mate, and Magnolia officinalis |
| title_full_unstemmed | Appetite Suppression and Antiobesity Effect of a Botanical Composition Composed of Morus alba, Yerba mate, and Magnolia officinalis |
| title_short | Appetite Suppression and Antiobesity Effect of a Botanical Composition Composed of Morus alba, Yerba mate, and Magnolia officinalis |
| title_sort | appetite suppression and antiobesity effect of a botanical composition composed of morus alba yerba mate and magnolia officinalis |
| url | http://dx.doi.org/10.1155/2016/4670818 |
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