Maternal obesity exacerbates the responsiveness of offspring BALB/c mice to cow’s milk protein-induced food allergy
Food allergy has become a significant public health problem affecting a large number of people worldwide. Maternal obesity causes inflammation and alters the immune system of offspring, which may exacerbate their food allergy. The aim of this study was to determine whether offspring mice born to obe...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tsinghua University Press
2023-05-01
|
| Series: | Food Science and Human Wellness |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453022002166 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832544355847503872 |
|---|---|
| author | Jingxin Gao Tiange Li Dong Liang Han Gong Liang Zhao Xueying Mao |
| author_facet | Jingxin Gao Tiange Li Dong Liang Han Gong Liang Zhao Xueying Mao |
| author_sort | Jingxin Gao |
| collection | DOAJ |
| description | Food allergy has become a significant public health problem affecting a large number of people worldwide. Maternal obesity causes inflammation and alters the immune system of offspring, which may exacerbate their food allergy. The aim of this study was to determine whether offspring mice born to obese mothers would have more serve reactions to cow’s milk protein-induced food allergy, and further investigate the underlying mechanisms. Female offspring BALB/c mice of mothers with normal and high-fat diets were sensitized with β-lactoglobulin (BLG), respectively. Maternal obesity increased the serum immunoglobulin E and mouse mast cell protease levels, though did not have significant influence on anaphylactic symptom score, core temperature and diarrhea rate of offspring mice after BLG sensitization. Furthermore, maternal obesity led to a lower level of occludin mRNA expression in BLG -sensitized mice. The mice born to obese mothers exhibited increased mRNA expression levels of GATA-3, interleukin (IL)-4 and IL-10 in jejunum after BLG sensitization, indicating maternal obesity intensified Th2-type biased immune responses. In conclusion, maternal obesity exerted exacerbating effects on the responsiveness of their offspring to cow’s milk protein sensitization. |
| format | Article |
| id | doaj-art-99ca5a5d275247619890282087e506eb |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2023-05-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-99ca5a5d275247619890282087e506eb2025-02-03T10:34:09ZengTsinghua University PressFood Science and Human Wellness2213-45302023-05-01123920928Maternal obesity exacerbates the responsiveness of offspring BALB/c mice to cow’s milk protein-induced food allergyJingxin Gao0Tiange Li1Dong Liang2Han Gong3Liang Zhao4Xueying Mao5Key Laboratory of Functional Dairy, Ministry of Education, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaHenan Engineering Technology Research Center of Food Processing and Circulation Safety Control, College of Food Science and Technology, Henan Agricultural University, Zhengzhou 450002, ChinaApplied Nutrition I, China National Center for Food Safety Risk Assessment, Beijing 100022, ChinaKey Laboratory of Functional Dairy, Ministry of Education, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaKey Laboratory of Functional Dairy, Ministry of Education, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaKey Laboratory of Functional Dairy, Ministry of Education, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China; Corresponding author at: Key Laboratory of Functional Dairy, Ministry of Education, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.Food allergy has become a significant public health problem affecting a large number of people worldwide. Maternal obesity causes inflammation and alters the immune system of offspring, which may exacerbate their food allergy. The aim of this study was to determine whether offspring mice born to obese mothers would have more serve reactions to cow’s milk protein-induced food allergy, and further investigate the underlying mechanisms. Female offspring BALB/c mice of mothers with normal and high-fat diets were sensitized with β-lactoglobulin (BLG), respectively. Maternal obesity increased the serum immunoglobulin E and mouse mast cell protease levels, though did not have significant influence on anaphylactic symptom score, core temperature and diarrhea rate of offspring mice after BLG sensitization. Furthermore, maternal obesity led to a lower level of occludin mRNA expression in BLG -sensitized mice. The mice born to obese mothers exhibited increased mRNA expression levels of GATA-3, interleukin (IL)-4 and IL-10 in jejunum after BLG sensitization, indicating maternal obesity intensified Th2-type biased immune responses. In conclusion, maternal obesity exerted exacerbating effects on the responsiveness of their offspring to cow’s milk protein sensitization.http://www.sciencedirect.com/science/article/pii/S2213453022002166Cow’s milk allergyMaternal obesityOffspringIntestinal barrierImmune response |
| spellingShingle | Jingxin Gao Tiange Li Dong Liang Han Gong Liang Zhao Xueying Mao Maternal obesity exacerbates the responsiveness of offspring BALB/c mice to cow’s milk protein-induced food allergy Food Science and Human Wellness Cow’s milk allergy Maternal obesity Offspring Intestinal barrier Immune response |
| title | Maternal obesity exacerbates the responsiveness of offspring BALB/c mice to cow’s milk protein-induced food allergy |
| title_full | Maternal obesity exacerbates the responsiveness of offspring BALB/c mice to cow’s milk protein-induced food allergy |
| title_fullStr | Maternal obesity exacerbates the responsiveness of offspring BALB/c mice to cow’s milk protein-induced food allergy |
| title_full_unstemmed | Maternal obesity exacerbates the responsiveness of offspring BALB/c mice to cow’s milk protein-induced food allergy |
| title_short | Maternal obesity exacerbates the responsiveness of offspring BALB/c mice to cow’s milk protein-induced food allergy |
| title_sort | maternal obesity exacerbates the responsiveness of offspring balb c mice to cow s milk protein induced food allergy |
| topic | Cow’s milk allergy Maternal obesity Offspring Intestinal barrier Immune response |
| url | http://www.sciencedirect.com/science/article/pii/S2213453022002166 |
| work_keys_str_mv | AT jingxingao maternalobesityexacerbatestheresponsivenessofoffspringbalbcmicetocowsmilkproteininducedfoodallergy AT tiangeli maternalobesityexacerbatestheresponsivenessofoffspringbalbcmicetocowsmilkproteininducedfoodallergy AT dongliang maternalobesityexacerbatestheresponsivenessofoffspringbalbcmicetocowsmilkproteininducedfoodallergy AT hangong maternalobesityexacerbatestheresponsivenessofoffspringbalbcmicetocowsmilkproteininducedfoodallergy AT liangzhao maternalobesityexacerbatestheresponsivenessofoffspringbalbcmicetocowsmilkproteininducedfoodallergy AT xueyingmao maternalobesityexacerbatestheresponsivenessofoffspringbalbcmicetocowsmilkproteininducedfoodallergy |