BCL-2 inhibitors in hematological malignancies: biomarkers that predict response and management strategies

BCL-2 inhibitors in hematological malignancies: biomarkers that predict response and management strategies

Apoptosis is an essential characteristic of cancer and its dysregular promotes tumor growth, clonal evolution, and treatment resistance. B-cell lymphoma-2 (BCL-2) protein family members are key to the intrinsic, mitochondrial apoptotic pathway. The inhibition of the BCL-2 family pro-survival protein...

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Bibliographic Details
Main Authors:	Mariam Markouli, Maria N. Pagoni, Panagiotis Diamantopoulos
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-01-01
Series:	Frontiers in Oncology
Subjects:	Bcl-2 inhibitors venetoclax apoptosis chronic lymphocytic leukemia acute myeloid leukemia DLBCL
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2024.1501950/full
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