Variations in ECM Topography, Fiber Alignment, Mechanical Stiffness, and Cellular Composition Between Ventral and Dorsal Ligamentum Flavum Layers: Insights Into Hypertrophy Pathogenesis

Variations in ECM Topography, Fiber Alignment, Mechanical Stiffness, and Cellular Composition Between Ventral and Dorsal Ligamentum Flavum Layers: Insights Into Hypertrophy Pathogenesis

ABSTRACT Background Previous studies have suggested that changes in the composition of the extracellular matrix (ECM) play a significant role in the development of ligamentum flavum hypertrophy (LFH) and the histological differences between the ventral and dorsal layers of the hypertrophied ligament...

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Bibliographic Details
Main Authors: Ting‐Yuan Tu, Yu‐Chia Hsu, Chia‐En Yang, Yan‐Jye Shyong, Cheng‐Hsiang Kuo, Yuan‐Fu Liu, Shu‐Shien Shih, Cheng‐Li Lin
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:JOR Spine
Subjects:
extracellular matrix
ligamentum flavum hypertrophy
mechanical property
myofibroblast
Online Access:https://doi.org/10.1002/jsp2.70033
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